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Shixin Liu on Muck Rack

Shixin Liu

As seen in: Nature, Wiley Online Library, PLOS ONE, Frontiers, MDPI, ACS Publications, BioRxiv, Cell Press, Cell Reports, Optica
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Articles

Dpb11 facilitates the colocalization of Mec1-Ddc2 with its activators on gapped DNA

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By Emily C. Beckwitt, Gabriella N.L. Chua, Shixin Liu, Michael E. O’Donnell
| Cell Reports Verified
Keywords: DNA damage response replication stress cell cycle checkpoint Mec1-Ddc2 ATR-ATRIP Dpb11 TopBP1 single-molecule microscopy Research topic(s) CP: molecular biology Introduction The DNA damage and replication stress checkpoint comprises crucial cellular responses for the maintenance of genome stability and prevention of carcinogenesis.1,2 This checkpoint can be triggered by single-stranded DNA (ssDNA) resulting from genotoxic challenges during the G1, S, or G2 phase of the cell cycle.
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Spatial and genetic constraints govern transcription–translation coupling and mRNA degradation in bacteria

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By Seunghyeon Kim, Yan Zhang, Xiangwu Ju, Albur Hassan, Yu-Huan Wang, Shixin Liu, Sangjin Kim
| Nature Verified
Abstract Bacterial gene expression is thought to involve tightly coupled transcription, translation and mRNA degradation. However, recent work has indicated that this is not always the case, leaving the generality and regulation of this coordination unclear.
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Transcription attenuation amplifies collateral vulnerabilities in rifampicin-resistant Mycobacterium tuberculosis

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By Vanisha Munsamy-Govender, Michael DeJesus, Xiangwu Ju, Shixin Liu, Jeremy M. Rock, Kathryn A. Eckartt, Stefany Quiñones-Garcia
| Nature Verified
Abstract Mycobacterium tuberculosis (Mtb) acquires resistance to rifampicin (Rif) through mutations in the β-subunit of RNA polymerase (RNAP) that prevent the drug from binding. The most common mutation is a single amino acid substitution, βS450L, that confers antibiotic resistance. This mutation also results in collateral effects that impact bacterial physiology and fitness, although the mechanisms underlying many of these effects remain unclear.
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