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Giacomo Cavalli on Muck Rack

Giacomo Cavalli

Montpellier
As seen in: British Journal of Cancer, Nature, Nature Reviews Genetics, The Conversation, CNRS, Science Magazine, Sud Ouest, European Heart Journal - Cardiovascular Imaging, Cell Press
Epigenetics, 3DGenome, Polycomb. 1991-1994: PhD @ETH Zürich 1995-1998 Postdoc, @UniHeidelberg. Since 1999: PI @IGH_MTP - mastodon.social/@giacomocavalli
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Articles

PRC1 nanoglobules organize Hox chromatin during Drosophila embryogenesis

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By Marco Di Stefano, Lauriane Fritsch, Daniel Jost, Giacomo Cavalli, Thierry Cheutin, Nazli Akilli, Paul-Swann Puel
| Nature Verified
Abstract Polycomb group (PcG) proteins are required to maintain the silencing of key developmental genes during development. In Drosophila, they bind to discrete genomic elements named Polycomb response elements (PREs). PcG proteins form two classes of complexes. Polycomb repressive complex 2 (PRC2) deposits H3K27me3, a histone mark that covers large chromatin domains. The canonical PRC1 complex can bind to PREs as well as to the H3K27me3 mark.
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The 3D architecture of the genome enables cells to remember their past

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By Giacomo Cavalli, Aurélie Meilhon
| CNRS
The researchers uncovered this phenomenon by exposing mouse embryonic stem cells to a compound employed in the treatment of certain cancers. The molecule modifies chromatin compaction² by activating some genes while preventing the transcription of others. To further validate their hypothesis, the team experimentally removed specific 3D genomic structures. Once they were lost, the cells could no longer retain their memory of the past exposure.
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3D genome folding in epigenetic regulation and cellular memory

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By Flora Paldi, Giacomo Cavalli
| Cell Press Verified
Keywords genome folding epigenetic regulation mitosis cellular memory Folding principles of the mammalian genome The earliest observations that implicated chromosome organisation in cellular function were made almost 150 years ago and described the restructuring and segregation of nuclear material during cell division [1].
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