Giada Del Baldo

1Pediatric Hematology/Oncology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Gesù Children’s Hospital, IRCCS, Rome, Latium, 00165, Italy 2Laboratory of Medical Genetics, Bambino Gesù Children’s Hospital, IRCCS, Rome, Latium, 00165, Italy 3Molecular Genetics and Functional Genomics, Bambino Gesù Children’s Hospital, IRCCS, Rome, Latium, 00165, Italy 4Pathology Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, Latium, 00165, Italy 5Predictive and Preventive Medicine...

The MutY DNA Glycosylase (MUTYH) gene is a primary component of the base excision repair (BER) pathway.1 It plays a role in fixing DNA damage caused by environmental factors, particularly in G:C to T:A transversions that result from guanine oxidation.1, 2 Biallelic germline pathogenic variants in MUTYH have been associated with a type of adenomatous polyposis affecting the colon and duodenum, known as MUTYH-associated polyposis (MAP).3 This condition follows an autosomal recessive hereditary...

1 Introduction Chimeric antigen receptor CAR-T cells can bind to recombinant chimeric tumor-associated antigen receptors. CAR-T cells often have costimulatory domains that function to enhance their activity, proliferation, and cytokine release (1–3). The various costimulatory molecules and components of CAR immune receptors help CAR-T cells recognize antigens and directly kill target cells (4–6).