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Abstract Retinoblastoma (RB) research is significantly constrained by the limited availability of preclinical models that accurately recapitulate the disease complexity, particularly regarding the context of vitreous seeding, a major driver of therapeutic resistance and treatment failure. Here, we report the establishment and integrative characterization of patient-derived, three-dimensional (3D) spheroid models generated from primary retinal tumors (RBT) and vitreous seeds (RBVS).
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement NGS raw data and chromosomal microarray analysis are available on request from the authors. Supporting Information Filename Description pcmr70071-sup-0001-TableS1.xlsxExcel 2007 spreadsheet , 108 KB Table S1: List of differentially expressed genes in mesenchymal vs. melanocytic lesions.
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