Han Sun
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Articles by Han Sun
Biodiversity Disclosure and Analyst Forecast Accuracy: Evidence From Chinese A-Share Firms
Supporting Information Filename Description csr71056-sup-0001-TableS1-S5.docxWord 2007 document , 26.7 KB Table S1: Threshold and functional-form robustness. Table S2: Forecast timing, horizon and coverage controls, and fixed post-publication windows. Table S3: Baseline specification under alternative transformations of forecast error. Table S4: Unexpected biodiversity disclosure and analyst forecast error: Alternative first-stage specifications.
Cross-talk of filter gate and lower helices drives polymodal regulation and disease in TREK channels
Abstract The TREK two-pore domain potassium channels regulate membrane excitability and respond to diverse physiological stimuli. Single-site mutations of TREK are associated with neurodevelopmental disorders and can cause pathological channel hyperactivation.
Atomic structure and plasticity of the CTX-MthK complex investigated by cryo-EM, NMR, and MD simulations
Abstract Scorpion toxins block potassium channels, disrupting cellular excitability and causing symptoms such as pain, muscle spasms, or paralysis. Here, we use an integrated structural biology approach to uncover the binding mode of the scorpion toxin charybdotoxin (CTX) to the MthK channel, a model system for human large-conductance potassium (BK) channels.
Bảo quản mỹ phẩm mùa hè: Tuyệt đối tránh những nơi này!
가 가 Nắng nóng và độ ẩm mùa hè là nguyên nhân chính khiến mỹ phẩm biến chất. Sự biến chất này không chỉ do nhiệt độ cao, mà còn là kết quả của phản ứng hóa học ở thành phần kết hợp với sự thay đổi vật lý của kết cấu sản phẩm. Trong điều kiện nóng ẩm mùa hè, mỹ phẩm rất dễ biến chất — nên nắm rõ cách bảo quản đúng cách (Ảnh = Hình ảnh do AI tạo).
夏季化妆品存放，这些地方千万别放！ < 美容信息 < 다국어 서비스 < 기사본문
가 가 夏季的酷热与潮湿是化妆品变质的主要原因。化妆品变质并非仅由高温引起，而是成分的化学反应与剂型的物理变化共同作用的结果。 夏季高温潮湿环境下化妆品容易变质，提前了解正确的保管方法十分必要（图片=AI生成图像）。 ■ 无防腐剂产品更易变质 近来备受欢迎的"无防腐剂"产品，使用替代成分而非韩国食品医药品安全处（MFDS）指定的防腐剂，防腐能力相对较弱，在高温潮湿环境下更容易变质。 ■ 最忌讳的存放场所之一：暴晒的车内 阳光直射下的车内是存放化妆品的头号禁区。盛夏时节，车内温度可升至90℃左右，加速维生素C、视黄醇等敏感成分氧化。高温还会破坏乳化状态导致分层，并使容器内空气膨胀，让微生物和细菌大量繁殖。 ■ 最忌讳的存放场所之二：浴室 浴室同样是细菌和霉菌滋生的最佳场所。洗澡后浴室内高温高湿（湿度80~90%），尤其容易污染水感、啫喱类产品。开合瓶盖时进入的水蒸气以及沾在手上的水分，也会破坏产品的稳定性。 ■ 正确的存放与使用习惯 建议将化妆品移至阴凉干燥处存放，挖取产品时养成使用挖勺的习惯。...
SLC7A11-mediated cystine accumulation and Rac1-WRC-Arp2/3-driven actin cytoskeletal folding synergistically induce disulfidptosis in acute myocardial infarction
Abstract Disulfidptosis, a newly identified form of cell death, holds significant biological relevance; however, its role in cardiovascular diseases remains poorly characterized. To investigate this, disulfide bond formation was evaluated using non-reducing Western blot, while cytoskeletal alterations were assessed via phalloidin staining.
Engineered microbial hydrogels with confined architecture and binary microbes for efficient hydrogen production
Abstract Renewable energy sources, particularly hydrogen, offer a promising solution to address global energy crisis and carbon emissions. Microalgae-driven hydrogen production has attracted immense interest in both scientific and industrial fields. However, challenges such as high oxygen sensitivity, substantial water demand, and low hydrogen production efficiency limit their potential.
Corticosteroids for Treating Sepsis: A Systematic Review and Network Meta-analysis
Keywords Corticosteroids meta-analysis mortality sepsis systematic review Get full text access Log in, subscribe or purchase for full access. Reference 1. Huang, M. ∙ Cai, S. ∙ Su, J. The Pathogenesis of Sepsis and Potential Therapeutic Targets Int J Mol Sci. 2019; 20(21) 2. Liu, D. ∙ Huang, S.Y. ∙ Sun, J.H. ... Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options Mil Med Res. 2022; 9(1):56 3.
Multiparameter Optimization and Dephosphorization Capacity Evaluation of Converter Slag Based on Response Surface Methodology, Industrial, and Laboratory Experiments
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. References 1, , , et al., “Dephosphorization in Double Slag Converter Steelmaking Process at Different Temperatures by Industrial Experiments,” Metals 11, no. 7 (2021): 1030, https://doi.org/10.3390/met11071030.
Multiparameter Optimization and Dephosphorization Capacity Evaluation of Converter Slag Based on Response Surface Methodology, Industrial, and Laboratory Experiments
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. References 1, , , et al., “Dephosphorization in Double Slag Converter Steelmaking Process at Different Temperatures by Industrial Experiments,” Metals 11, no. 7 (2021): 1030, https://doi.org/10.3390/met11071030.
Selectivity Filter Dynamics Define Ion Conductance and Selectivity Differences in CNG and HCN Channels
1 Introduction Cyclic nucleotide-activated ion channels are opened by binding of cyclic nucleotide, thereby converting intracellular signaling into electrical activity [1-4]. This family comprises cyclic nucleotide-gated (CNG) channels and hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that serve fundamentally different physiological functions, despite their structural similarity [3].
Heat Transfer Analysis of a Wetted Moving Porous Fin Under Combined Magneto‐Radiative‐Convective Effects With Different Internal Heat Sources via Differential Transformation Method
The differential transformation method (DTM) is utilized to analyze the thermal performance of a wetted moving porous rectangular fin under combined magneto-radiative-convective effects considering different internal heat sources.
How does environmental regulation affect the cobalt supply chain resilience: empirical evidence from cross-border data
1 Introduction With the increasing frequency of extreme climate events, the accelerated transition to renewable energy, and the surge in demand from emerging technologies, the stability and security of mineral resources supply chain have drawn a central issue in the geopolitical competition of major powers (Turner, 2022).
Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function - Nature Genetics
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By Reza Asadollahi, Boris Bouazza-Arostegui, Siqi Sun, Tillmann Utesch, Amélie Piton, Katrin Õunap, Monica H. Wojcik, Christian R Marshall, Naomichi Matsumoto, Noriko Miyake, Chong Ae Kim, Heather C Mefford, John Christodoulou, Joy Lee, Oliver Heath, Zornitza Stark, Nicole J Lake, Shimriet Zeidler, Konrad Platzer, Rami Abou Jamra, Robert Śmigiel, Katherine L. Helbig, Ingo Helbig, Mark Fitzgerald, Carlos Prada, Sylvia Redon, Stephanie Efthymiou, Reza Maroofian, Henry Houlden, Philippe M Campeau, Anna Szuto, Ronald Cohn, Aboulfazl Rad, Gabriela Oprea, Emanuele Agolini, Alessandra Terracciano, Caleb P. Bupp, Malou Heijligers, Fowzan S. Alkuraya, Antonio Edvan Camelo-Filho, Lydie Burglen, Caroline Nava, Sven Thoms, Aaron D. Gitler, Olaf Jahn, Miso Mitkovski, Heinrich Sticht, Han Sun, Holger Taschenberger, Nils Brose, Anita Rauch, Mareike Lohse, Balasubramaniem Ashokkumar, Perumal Varalakshmi, John Neidhardt, Amy Margolin
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Nature
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APGNet: Adaptive Prior-Guided for Underwater Camouflaged Object Detection
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The ω6 Pathway toward Eicosapentaenoic Acid Biosynthesis outside the Chloroplast in the Industrially Relevant Alga Nannochloropsis oceanica
Cite Jump to ExpandCollapse Biofuels and Biobased MaterialsOctober 11, 2025 The ω6 Pathway toward Eicosapentaenoic Acid Biosynthesis outside the Chloroplast in the Industrially Relevant Alga Nannochloropsis oceanica Click to copy article linkArticle link copied! Jie Zheng Jie Zheng Key Laboratory of Poyang Lake Environment and Resource Utilization Ministry of Education, and Center for Algae Innovation & Engineering Research, School of Resources and Environment, Nanchang University, Nanchang...
Tumour necrosis factor alpha-inducing protein 3 (TNFAIP3) can independently predict coronary heart disease (CHD)
Multiple indicators of inflammation are significantly associated with coronary heart disease (CHD). Tumour necrosis factor alpha-inducible protein 3 (TNFAIP3) is an anti-inflammatory protein that inhibits inflammatory responses. However, the relationship between TNFAIP3 and CHD is currently unknown. This study included 236 patients.
Atomistic mechanism of non-selective cation permeation in cyclic nucleotide-gated CNGA1 ion channel by molecular dynamics simulations - Communications Biology
Abstract Mammalian cyclic nucleotide-gated (CNG) ion channels play a fundamental role in signal transduction within the visual and olfactory sensory cells, converting external stimuli into electrical signals. Here, using large-scale atomistic molecular dynamics (MD) simulations of three different constructs under applied transmembrane voltages, we uncover the atomistic mechanism of monovalent cation permeation in the homotetrameric CNGA1 channel.
The bioinformatics analysis of publicly available datasets and validat
Back to Journals » Journal of Inflammation Research » Volume 19 Original Research Cardiovascular Inflammation Authors Sun H , Liu F, Sun M, Wang W, Wang J , Wang H, Jiang X, Ding X, Wang C , Zhong L Received 4 August 2025 Accepted for publication 27 December 2025 Published 6 January 2026 Volume 2026:19 Pages 1—17 DOI https://doi.org/10.2147/JIR.S558274 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Prof.
Transcriptome analysis reveals possible antitumor mechanism of intracellular polysaccharide from Phaeodactylum tricornutum on cervical cancer HeLa cells
As a natural non-toxic antitumor substance, seaweed polysaccharide has become a research hotspot. To investigate the anti-tumor effect and mechanism of Phaeodactylum tricornutum intracellular polysaccharides, the intracellular polysaccharides from Phaeodactylum tricornutum (PRP) were isolated and purified in this paper.
High-Quality Classroom Dialogue Automatic Analysis System
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Positive allosteric modulation of emodepside sensitive Brugia malayi SLO-1F and Onchocerca volvulus SLO-1A potassium channels by GoSlo-SR-5-69
Abstract Human lymphatic filariasis and onchocerciasis are Neglected Tropical Diseases (NTDs), of major public health concern. Prophylaxis and treatment rely on anthelmintics that effectively eliminate migrating microfilariae but lack efficacy against adult filarial worms. To expedite the elimination of both diseases, the introduction of drugs with adulticidal activity is paramount.
Structural insights into light-gating of potassium-selective channelrhodopsin - Nature Communications
Abstract Structural information on channelrhodopsins’ mechanism of light-gated ion conductance is scarce, limiting its engineering as optogenetic tools. Here, we use single-particle cryo-electron microscopy of peptidisc-incorporated protein samples to determine the structures of the slow-cycling mutant C110A of kalium channelrhodopsin 1 from Hyphochytrium catenoides (HcKCR1) in the dark and upon laser flash excitation.
Structural insights into light-gating of potassium-selective channelrhodopsin
2 days ago I Just Spent The Past 15 Minutes With My Jaw On The Floor After Seeing All These Fascinating Pictures For The First Time And Now I Need You To See Them Truly amazing stuff. Enjoy. 1. These are the contestants for the 1924 Miss America pageant: Looks like they raided the backstage at my high school drama club. 2.
Cell type-specific eQTL detection from single-cell RNA-seq reveals post-transcriptional regulatory mechanisms in human islets
Abstract Gene regulatory networks (GRN) must be robust to maintain cellular identity across individuals yet flexible to accommodate population genetic variants. Therefore, comparing expression quantitative trait loci (eQTL) in health and disease can reveal hidden players in GRN and post-transcriptional regulation. Here, we developed a computational pipeline to investigate the gain and loss of eQTLs in the 3' untranslated region of genes using single-cell RNA sequencing.
HumanIslets.com: Improving accessibility, integration, and usability of human research islet data
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ForumVolume 37, Issue 1p7-11 1Institute of Parasitology, McGill University, Montreal, QC, Canada 2Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA 3Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada 4Department of Pharmacology, University of Alberta, Edmonton, AB, Canada 5Department of Surgery, University of Alberta, Edmonton, AB, Canada 6Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia,...
By Jessica D. Ewald, Yao Lu, Cara E. Ellis, Jessica Worton, Jelena Kolic, Shugo Sasaki, Dahai Zhang, Theodore dos Santos, Aliya F. Spigelman, Austin Bautista, Xiao-Qing Dai, James Lyon, Nancy Smith, Jordan Wong, Varsha Rajesh, Han Sun, Seth Sharp, Jason C. Rogalski, Renata Moravcová, Haoning Cen, Ella Atlas, Jennifer E. Bruin, Erin E. Mulvihill, C. Bruce Verchere, Leonard Foster, Anna L Gloyn, James Johnson Verified, Andrew R. Pepper, Francis C. Lynn, Jianguo Xia, Patrick Macdonald
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Cell Metabolism
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Semisupervised Contrastive Learning for Bioactivity Prediction Using Cell Painting Image Data
1. Introduction Click to copy section linkSection link copied! The Cell Painting (CP) assay is a high-content screening method that enables an unbiased and high-throughput evaluation of pharmacological similarity among compounds by comparing the drug-induced morphological changes on cells.
Semisupervised Contrastive Learning for Bioactivity Prediction Using Cell Painting Image Data
1. Introduction Click to copy section linkSection link copied! The Cell Painting (CP) assay is a high-content screening method that enables an unbiased and high-throughput evaluation of pharmacological similarity among compounds by comparing the drug-induced morphological changes on cells.
Benchmark of Density Functional Theory in the Prediction of 13C Chemical Shielding Anisotropies for Anisotropic Nuclear Magnetic Resonance-Based Structural Elucidation
1. Introduction Click to copy section linkSection link copied! Anisotropic nuclear magnetic resonance (NMR) spectroscopy in solution has been proven for over three decades to provide invaluable structural and dynamic information about biomolecules, particularly proteins and nucleic acids.
Research on Ni-WC Coating and a Carbide Solidification Simulation Mechanism of PTAW on the Descaling Roll Surface
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
TAT as a new marker and its use for noninvasive chemical biopsy in NASH diagnosis - Molecular Medicine
Abstract Early diagnosis of Nonalcoholic steatohepatitis (NASH) is crucial to prevent its progression to hepatocellular carcinoma, but its gold standard diagnosis still requires invasive biopsy. Here, a new marker-based noninvasive chemical biopsy approach is introduced that uses urine-secreted tyrosine metabolites.
Semi-supervised Contrastive Learning for Bioactivity Prediction using Cell Painting Image Data
Abstract Morphological profiling has recently demonstrated remarkable potential for identifying the biologi-cal activities of small molecules. Alongside the fully supervised and self-supervised machine learn-ing methods recently proposed for bioactivity prediction from Cell Painting image data, we intro-duce here a semi-supervised contrastive (SemiSupCon) learning approach.
Electrochemical Migration Study on Sn-58Bi Lead-Free Solder Alloy Under Dust Contamination
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Transcriptomic Insights into the Atrial Fibrillation Susceptibility Locus near the MYOZ1 and SYNPO2L Genes
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Avicularin Attenuated Lead-Induced Ferroptosis, Neuroinflammation, and Memory Impairment in Mice
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
RA-YOLOv8: An Improved YOLOv8 Seal Text Detection Method
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Synthesis of Chabazite Zeolite via Faujasite Conversion Using 1‐(1‐Methylpropyl)‐4‐aza‐1‐azoniabicyclo[2.2.2]octane Hydroxide as Cost‐Effective Structure‐Directing Agent
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
A Rapid Response System for Elderly Safety Monitoring Using Progressive Hierarchical Action Recognition
Loading [a11y]/accessibility-menu.js A Rapid Response System for Elderly Safety Monitoring Using Progressive Hierarchical Action Recognition | IEEE Journals & Magazine | IEEE Xplore Skip to Main Content Abstract: The global trend of population aging presents an urgent challenge in ensuring the safety and well-being of elderly individuals, especially those living alone due to vario...View more Metadata Abstract: The global trend of population aging presents an urgent challenge in ensuring the...
Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease
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Keywords human islets type 2 diabetes stem cell-derived islets insulin secretion proteomics macronutrients RNA-seq Introduction Insulin is released by pancreatic islet beta cells in response to nutrient stimuli to maintain energy homeostasis. The major driver of insulin secretion is glucose. However, proteins and fats may also modulate insulin release, and the effects of non-carbohydrate nutrients on insulin secretion remain underexplored.
By Jelena Kolic, Wenqing Sun, Haoning Cen, Jessica D. Ewald, Jason C. Rogalski, Shugo Sasaki, Han Sun, Varsha Rajesh, Yi Xia, Renata Moravcová, Søs Skovsø, Aliya F. Spigelman, James Lyon, Leanne Beet, Jianguo Xia, Francis C. Lynn, Anna L Gloyn, Leonard Foster, Patrick Macdonald, James Johnson Verified
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Cell Metabolism
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A double‐edged sword: Interim CEO and corporate social (ir)responsibility activities
REFERENCES , & (2022). Founder CEOs and corporate environmental violations: Evidence from S&P 1500 firms. Business Strategy and the Environment, 31(3), 1204–1219. , & (1998). An analysis of corporate donations: United Kingdom evidence. Journal of Management Studies, 35(5), 641–654. , & (2012). What we know and don't know about corporate social responsibility: A review and research agenda. Journal of Management, 38(4), 932–968. , , , & (2022). Can you hear me now?
Effect of Melatonin on the Growth of Dendrobium officinale Protocorm-like Bodies
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Deuteration as a General Strategy to Enhance Azobenzene‐Based Photopharmacology
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Influence of the Basicity on Phosphorus Enrichment Properties of Decarbonization Slag in Low‐Carbon Double Slag Converter Steelmaking Process with Industrial Experiments, Mineralogy, and Ion-molecule Coexistence Theory - Sun - steel research international
Conflict of Interest The authors declare no conflict of interest. References 1 Worldsteel Association, https://worldsteel.org/zh-hans/media-centre/press-releases/2023/december-2022-crude-steel-production-and-2022-global-totals/ (accessed: January 2023). 2 , , , , Metals 2022, 12, 797. 3 Xinhuanet, http://www.xinhuanet.com/science/2022-11/19/c_1310678139.htm (accessed: January 2023). 4 , , , , Steel Res. Int. 2003, 74, 70. 5 , Nippon Steel Tech. Rep. 2013, 394, 5. 6 , , J. Clean. Prod. 2022, 373, 133876.
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