Hani Kim
Seattle
As seen in:
Color Research & Application,
Nature,
MDPI,
BioRxiv,
Cell Press,
Cell Reports,
Stem Cell Reports
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Articles by Hani Kim
Oxygen-dependent subcellular redistribution of PHD3 links the hypoxic microenvironment to mitochondrial metabolic reprogramming in ccRCC
Abstract Clear cell renal cell carcinoma (ccRCC) is characterized by profound metabolic dysregulation, with both prolyl hydroxylase domain protein 3 (PHD3) and pyruvate carboxylase (PC) independently implicated in disease progression. Although each influences patient outcomes, a direct mechanistic interplay between these two regulators has remained elusive.
Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator - Nature Communications
Abstract Insulin action on the skeleton is essential for bone development and whole-body energy metabolism, however a global view of signaling in this tissue is lacking. Furthermore, whether there are signaling differences that drive the gene-specific activation under insulin-resistant (IR) or ageing conditions is unknown.
Connecting cilium, stress response, and proteostasis abnormalities inform variant and therapy assessment in RPGRIP1 retinal organoids
Results We applied TruSight One Clinical Exome sequencing to examine a bioinformatic gene panel of 65 IRD genes, which identified RPGRIP1 variants in 2 patients, LCA-1 and LCA-2, with poor vision and nystagmus manifested in the first 3 months of life. Electroretinograms showed reduced responses, and poor visual acuity was consistent at last review at ages 29 and 27 years for LCA-1 and LCA-2, respectively, with ophthalmic changes characteristic of LCA (Figures S1A and S1B).
Lineage contribution of the mesendoderm progenitors in the gastrulating mouse embryo
Keywords mesendoderm endoderm lineage differentiation gastrulation mouse epiblast stem cells micropattern single cell RNA sequencing analyis mouse embryos endoderm differentiation Get full text access Log in, subscribe or purchase for full access. References 1. Solnica-Krezel, L. ∙ Sepich, D.S. Gastrulation: making and shaping germ layers Annu. Rev. Cell Dev. Biol. 2012; 28:687-717 2. Smith, A. Formative pluripotency: the executive phase in a developmental continuum Development. 2017; 144:365-373 3.
Systematic evaluation of blastoid models of early human development
Abstract Recent generation of stem cell-derived blastoids that recapitulate the architecture and cellular constitution of the human blastocyst offers an experimental model for the elucidation of the biology of early human development.
Characterization of the mesendoderm progenitors in the gastrulating mouse embryo
Abstract A population of putative mesendoderm progenitor cells that can contribute cellular descendants to both mesoderm and endoderm lineages is identified. These progenitor cells are localized to the anterior primitive streak and the adjacent epiblast of E7.0-E7.5 mid- to late-gastrula stage embryos. Lineage tracing in vivo revealed that putative mesendoderm progenitors that are marked by Mixl1 and Mesp1 activity contribute descendants to the endoderm layer.
Comprehensive characterization of fetal and mature retinal cell identity to assess the fidelity of retinal organoids
Li et al., 2009 Li J. Bushel P.R. Chu T.-M. Wolfinger R.D. Principal variance components analysis: estimating batch effects in microarray gene expression data. in: Batch Effects and Noise in Microarray Experiments. John Wiley & Sons, Ltd, : 141-154 ) on all pairs of batches across datasets to quantify the degree of variance contributed by batch source ( Finally, we performed principal variance component analysis (Figure 2B).
The implicit ideological function of the global health field and its role in maintaining relations of power
The implicit ideological function of the global health field and its role in maintaining relations of power Statistics from Altmetric.com health policy public health Summary box In an unequal and unjust society, every field of study performs an implicit ideological function of legitimising and reproducing the existing power structure in addition to its explicit goal.
PhosR enables processing and functional analysis of phosphoproteomic data
Highlights • PhosR implements a suite of methods for comprehensive phosphoproteomic data analysis • Stably phosphorylated sites are useful for phospho-data normalization and integration • Signalomes constructed from PhosR enable interpretation of global signal transduction • PhosR reveals unappreciated interactions between the AMPK and insulin signaling Summary Mass spectrometry (MS)-based phosphoproteomics has revolutionized our ability to profile phosphorylation-based signaling in cells and...
Multistakeholder partnerships with the Democratic Peoples' Republic of Korea to improve childhood immunisation: A perspective from global health equity and political determinants of health equity - Kim - 2016 - Tropical Medicine & International Health
To examine the current partnerships to improve the childhood immunisation programme in the Democratic Peoples' Republic of Korea (DPRK) in the context of the political determinants of health equity. A literature search was conducted to identify public health collaborations with the DPRK government. Based on the amount of publicly accessible data and a shared approach in health system strengthening among the partners in immunisation programmes, the search focused on these partnerships.
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