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Haoyuan Yin

As seen in: Nature, Wiley Online Library, Taylor & Francis Online, Cell Press, Canadian Journal of Infectious Diseases & Medical Microbiology, Aging
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Articles

Modulation of the mevalonate pathway by TCR engagement regulates T follicular helper cell generation in homeostasis and autoimmunity

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By Lai Wang, Jiao Jiang, Haoyuan Yin, Junhui Wu, Xiaoyu Su, Lingchang Meng, Lulu Wang, Jingjing Bao, Qilin Li, Yunbo Wei, Zhian Chen, Jialei Gong, Pablo F. Cañete, Meiling Zheng, Wenrui Li, Qiongqiong Zhou, Ming Zhao, Di Yu, Qianjin Lu
| Cell Press Verified
Keywords T follicular helper cells geranylgeranyl diphosphate surface protein expression CXCR5 RAB35 pitavastatin autoimmune diseases Introduction CXCR5-expressing CD4+ T follicular helper (Tfh) cells are crucial for humoral immunity and the orchestrators of the germinal center (GC) reaction by providing critical signals that promote B cell survival, proliferation, class switching, and affinity maturation.1,2 While Tfh cell activity is integral to the protective humoral response elicited by...
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Spatial characterization of skin lesions in discoid and systemic lupus erythematosus

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By Wenhui Zhou, Yufen Huang, Yu Lei, Jingru Tian, Zhao Zhang, Hai Long, Hải Long, Yi Yang, Wei Shi, Jiajun Huang, Hongjun Zhao, Haoyuan Yin, Meiling Zheng, Zhi Gang Hu, Bo Zhang, Xiaodong Fang, Haijing Wu, Junpu Mei, Ming Zhao, Qianjin Lu, Rouxi Chen, Qianmei Liu
| Nature Verified
Abstract Lupus erythematosus (LE) skin lesions are associated with significant dysregulation of the local immune microenvironment. However, the spatial distribution and interactions between stromal and immune cells within affected tissues remain poorly characterized. In this study, we employed Stereo-seq to construct a single-cell resolution spatial transcriptomic atlas of lesional skin from patients with discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE).
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Aberrant Nutrient Metabolism in T Cells: Pathogenesis Insight and Therapeutic Target for Autoimmune Diseases

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By Shumei Cao Cao, Jiao Jiang, Haoyuan Yin, STIs Nanjing
| Wiley Online Library Verified
EAE experimental autoimmune encephalomyelitis MS multiple sclerosis RA rheumatoid arthritis SLE systemic lupus erythematosus 1 Introduction Autoimmune disorders, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and multiple sclerosis (MS), are featured by aberrant B and T cell responses against self-antigens [1].
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