Hossein Borghaei on Muck Rack

Hossein Borghaei

Philadelphia
As seen in: Color Research & Application, Nature, Wiley, Wiley Online Library, The Oncologist, JAMA (The Journal of the American Medical Association), Medscape, Cell Press, The Lancet, Healio and
Chief of Thoracic Medical Oncology and Director of Lung Cancer Risk Assessment at Fox Chase Cancer Center
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Articles

Multiomic characterization of small cell lung cancer: Real‐world insights into therapeutic opportunities

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By Sonam Puri, Andrew Elliott, Abdul Rafeh Naqash, Kathleen Kerrigan, Shiven Patel, Andreas Seeber, Florian Kocher, Dipesh Uprety, Hirva Mamdani, Amit Kulkarni, Gilberto Lopes, Balazs Halmos, Hossein Borghaei, Hassan Abu Shukair
| Wiley Online Library
INTRODUCTION Small cell lung cancer (SCLC) is characterized by an aggressive biology, poor prognosis, and lack of effective strategies for early detection.1 SCLC has historically been considered a homogeneous disease, and this has informed the current management approach for all patients with newly diagnosed extensive-stage SCLC to be treated with platinum-etoposide plus immunotherapy-based regimens as frontline therapy.2 The introduction of immune checkpoint blockade (ICB) into the frontline...
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Integrated molecular and clinical characterization of pulmonary large cell neuroendocrine carcinoma - Nature Communications

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By Amin H. Nassar, Elias Farhat, Mehrdad Rakaee, Shun-Fat Lau, Antonio Ocejo, Suresh S. Ramalingam, Jhanelle E Gray, Fabrizio Citarella, Alessio Cortellini, Emanuele Claudio Mingo, Timothy John Ellis-Caleo, Arthi Sridhar, Fionnuala Crowley, Thomas U Marron, Jun Zhang, David J. Pinato, Ana Karen Velazquez , Laura Moliner, Miguel Mosteiro, Ari VanderWalde, Andrew Elliott, Jorge Nieva, Hossein Borghaei, Roy S. Herbst, Richard A. Flavell
| Nature
Abstract Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a rare, aggressive lung tumor marked by significant molecular heterogeneity. In a study of 590 patients across two independent cohorts, we observe comparable overall survival across treatment regimens (chemotherapy, chemoimmunotherapy, immunotherapy) without unexpected adverse events.
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By Hossein Borghaei, Solange Peters, Margarita Majem, Ki Hyeong Lee
| chase.com
Jazz Pharmaceuticals Showcases Transformative Data at ASCO 2025, Highlighting Advances in Small Cell Lung Cancer, HER2+ Gastroesophageal Cancer and Diffuse Glioma 4:15 PM EDT 4/23/2025 - Comtex DUBLIN, April 23, 2025 /PRNewswire via COMTEX News Network/ -- Statistically significant and clinically meaningful progression-free survival (PFS) and overall survival (OS) data for Zepzelca (lurbinectedin) and atezolizumab (Tecentriq) combination underscore potential of first-line maintenance therapy...
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