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Huilong Yin on Muck Rack

Huilong Yin

As seen in: Nature, PLOS Biology
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Articles

p53 hotspot mutants attenuate CTL-mediated tumor cell killing through a novel ALKBH5-YTHDF3-PD-L1 pathway

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By Zhuan Ju, Xiang Zhang, Wenjie Zuo, Lu Zhang, Xin Fan, Chenxing Zhang, Xiaofang Zhang, Xiao Jun Zhang, Yidi WANG, Ying Xing, Baile Zuo, Angang Yang, Rui Zhang, Huilong Yin
| Nature Verified
Abstract TP53 is a well-documented tumor suppressor gene frequently mutated in malignancies. It has been demonstrated that the gain-of-function (GOF) mutation of p53 promotes the development and progression of cancers; however, its extrinsic oncogenic mechanisms are still poorly understood. Herein, we found that the oncogenic effect of mutant p53 in vivo is dependent on the tumor immune microenvironment.
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Loss of the m6A methyltransferase METTL3 in monocyte-derived macrophages ameliorates Alzheimer’s disease pathology in mice

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By Minhua Zheng, Xiang Zhang, Huilong Yin, Zhuan Ju
| PLOS Biology Verified
DNMT3A transcriptionally regulates the expression of ATAT1 As an epigenetic modifier, DNMT3A usually binds directly to the gene promoter to regulate transcription [38]. Accordingly, DNMT3A was found to directly bind to both the proximal promoters and distal promoters of Atat1 in BMDMs by chromatin-immunoprecipitation (ChIP) assay (Fig 5A).
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