Xiao Jun Zhang on Muck Rack

Xiao Jun Zhang

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As seen in: Nature, Journal of Automated Methods and Management in Chemistry, MDPI, Canadian Journal of Infectious Diseases & Medical Microbiology, Journal of Sensors, Physical Review B, Mechanical Engineering Magazine, Dialnet - Universidad de La Rioja, Physiological Research, Journal of Food Protection and
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Articles

Mechanistic study of HES1/PI3K/Akt/mTOR signaling pathway in cisplatin-induced sensorineural hearing loss

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By Yang Xiao, Ce Zhang, Yuewen Li, Dong Su, Meihua Sun, Xiao Jun Zhang, Jing Ma, Tiesong Zhang, Oulai Li, Chuxiong Gong
| Nature Verified
Abstract Cisplatin-induced ototoxicity limits its clinical utility and may adversely impact cochlear implant outcomes. This study investigated the role of the HES1/PI3K/AKT/mTOR signaling axis in cisplatin-evoked cytotoxicity in HEI-OC1 auditory cells. Our results demonstrated that cisplatin treatment significantly upregulated HMGB1/NLRP3-mediated inflammatory responses, as evidenced by increased protein levels of HMGB1 and NLRP3, along with elevated mRNA expression of TNF-α, IL-6, and IL-1β.
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Autonomous driving system based on dual process theory and deliberate practice theory

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By Xiao Jun Zhang, Tianyu Hu, Juntao Lyu, Qiankun Liu, Qianchuan Zhao, Mingyi Li, JianSheng Chen, Huimin Ma, Songde Han
| Nature Verified
Abstract Autonomous driving, despite significant progress, is still not widely applied in open, unconstrained environments, primarily owing to deficiencies in hazard perception, few-shot generalization, corner case generalization, and evaluation metrics, resulting in reliability concerns.
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Oncogenic LPP facilitates focal adhesion maturation in response to mechanical tension and regulates the Hippo signaling

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By Liu Huang, Mingyu Li, Xiao Jun Zhang, Jiaming Lin, Min Qin, Lian Chen, Man Yu, Ganlu Sun, Ershuo Geng
| Nature Verified
Abstract LIM family proteins play pivotal roles in mechano-transduction, a process often dysregulated in human cancers. However, the functions and mechanisms of LIM proteins in tumor biology remain insufficiently characterized. In this study, we demonstrate that the LIM family protein Lipoma Preferred Partner (LPP) is amplified and its expression is upregulated in various human cancer samples, correlating with poor prognosis.
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