I-Chun Chen on Muck Rack

I-Chun Chen

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Articles

Lidocaine Enhances Anti-Tumor Immune Responses by Reprogramming Tumor-Infiltrating Immune Cells in Gastric Cancer

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By Yi-Ying Wu, Ming-Shan Chen, I-Chun Chen, Feng-Hsu Wu
| preprints.org
Submitted: 24 February 2025 You are already at the latest version Lidocaine, a local anesthetic, has been shown to modulate immune responses. This study examines its effects on cytokine production in peripheral blood mononuclear cells (PBMCs) from healthy donors and tumor-infiltrating immune cells (TIICs) from gastric cancer patients.PBMCs from healthy donors and TIICs from gastric cancer patients were treated with lidocaine.
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Hormone therapy enhances anti-PD1 efficacy in premenopausal estrogen receptor-positive and HER2-negative advanced breast cancer

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By I-Chun Chen, Ching-Hung Lin, Tom Chen, Ming-Yang Wang, Yi-Ting Lin, Shu-Min Huang, Chia-Lang Hsu, Yen-Shen Lu, Dwan-Ying Chang, Wei-Li Ma
| Cell Reports Medicine Verified
Keywords immunotherapy hormone therapy gonadotropin-releasing hormone agonits estrogen receptor positive/HER2 negative metastatic breast cancer luminal subtype tumor microenvironment estrogen suppression cancer immune cell infiltration Introduction Immunotherapy has revolutionized the treatment of most cancer types in the past decade.1 Among various breast cancer (BC) types, immunotherapy is proven to be effective first in triple-negative BC (TNBC) either in the neoadjuvant setting for early...
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Lidocaine Modulates Cytokine Production and Enhances Anti-Tumor Immune Response in Gastric Cancer: Dual Effects on Normal Peripheral Blood Mononuclear Cells and Primary Gastric Tumor-Infiltrating Immune Cells

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By Yi-Ying Wu, I-Chun Chen, Ming-Shan Chen, Feng-Hsu Wu
| preprints.org
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 11 October 2024 / Approved: 11 October 2024 / Online: 11 October 2024 (06:13:46 CEST) Wu, Y.-Y.; Chen, M.-S.; Chen, I.-C.; Wu, F.-H.; Liao, T.-L.; Wen, H.-W.; Nielsen, B. L.; Liu, H.-J. Lidocaine Modulates Cytokine Production and Enhances Anti-Tumor Immune Response in Gastric Cancer: Dual Effects on Normal Peripheral Blood Mononuclear Cells and Primary Gastric Tumor-Infiltrating Immune Cells.
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