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Articles by Irit Sagi
Long-lasting extracellular matrix modifications reshape intestinal stem cell fate and promote chronic inflammation
Keywords tissue regeneration extracellular matrix ECM T cell recruitment ECM remodeling colon pathological reprogramming intestinal stem cell ISC collagen XVIII wound-associated epithelia Get full text access Log in, subscribe or purchase for full access. References 1. Peterson, L.W. ∙ Artis, D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis Nat. Rev. Immunol. 2014; 14:141-153 2. Biton, M. ∙ Haber, A.L. ∙ Rogel, N. ...
Tumor-draining lymph nodes in ovarian cancer lack germinal centers but harbor tumor-reactive memory B cells clonally linked to intra-tumoral B cells
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Keywords B cells ovarian cancer germinal centers antibodies high-grade serous ovarian cancer Get full text access Log in, subscribe or purchase for full access. References 1. Perets, R. ∙ Wyant, G.A. ∙ Muto, K.W. ... Transformation of the Fallopian Tube Secretory Epithelium Leads to High-Grade Serous Ovarian Cancer in Brca;Tp53;Pten Models Cancer Cell. 2013; 24:751-765 2. Dubeau, L. ∙ Drapkin, R. Coming into focus: the nonovarian origins of ovarian cancer Ann. Oncol. 2013; 24:viii28-viii35 3.
By Nachum Nathan, Philipp Paparoditis, Avital Sarusi-Portuguez, Liat Stoler-Barak, Hannah Horn, Idan Milo, Roei D. Mazor, Adva Levy-Barda, Natalia Yanichkin, Nicholas Borcherding, Ronnie Blecher-Gonen, Revital Ronen, Inbal Bolocan Nachman, Inna Goliand, Liat Fellus-Alyagor, Tomer-Meir Salame, Irit Sagi, Menachem Gross, Ariel Tenenbaum, Ilan Kent, Leeat Keren, Ram Eitan, Ziv Shulman, Goni Hout Siloni, Oded Raban
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Cell Press
Verified
Tumor-draining lymph nodes in ovarian cancer lack germinal centers but harbor tumor-reactive memory B cells clonally linked to intra-tumoral B cells
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Keywords B cells ovarian cancer germinal centers antibodies high-grade serous ovarian cancer Get full text access Log in, subscribe or purchase for full access. References 1. Perets, R. ∙ Wyant, G.A. ∙ Muto, K.W. ... Transformation of the Fallopian Tube Secretory Epithelium Leads to High-Grade Serous Ovarian Cancer in Brca;Tp53;Pten Models Cancer Cell. 2013; 24:751-765 2. Dubeau, L. ∙ Drapkin, R. Coming into focus: the nonovarian origins of ovarian cancer Ann. Oncol. 2013; 24:viii28-viii35 3.
By Nachum Nathan, Philipp Paparoditis, Avital Sarusi-Portuguez, Liat Stoler-Barak, Hannah Horn, Idan Milo, Roei D. Mazor, Adva Levy-Barda, Natalia Yanichkin, Nicholas Borcherding, Ronnie Blecher-Gonen, Revital Ronen, Inbal Bolocan Nachman, Inna Goliand, Liat Fellus-Alyagor, Tomer-Meir Salame, Irit Sagi, Goni Hout Siloni, Menachem Gross, Ariel Tenenbaum, Ilan Kent, Leeat Keren, Oded Raban, Ram Eitan, Ziv Shulman
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Cell Press
Verified
It’s time to rethink academic innovation: why technology transfer offices can’t do it alone
A new translational research unit at the Weizmann Institute of Science complements the work of the technology transfer office and bridges the translation gap with strategic, operational and resource frameworks that go beyond traditional commercialization infrastructure.
Altered extracellular matrix structure and elevated stiffness in a brain organoid model for disease - Nature Communications
Abstract The viscoelastic properties of tissues influence their morphology and cellular behavior, yet little is known about changes in these properties during brain malformations. Lissencephaly, a severe cortical malformation caused by LIS1 mutations, results in a smooth cortex. Here, we show that human-derived brain organoids with LIS1 mutation exhibit increased stiffness compared to controls at multiple developmental stages.
Integrated Metabolomics and Proteomics of Symptomatic and Early Presymptomatic States of Colitis
Colitis has a multifactorial pathogenesis with a strong cross-talk among microbiota, hypoxia, and tissue metabolism. Here, we aimed to characterize the molecular signature of the disease in symptomatic and presymptomatic stages of the inflammatory process at the tissue and fecal level.
Correction: Cardiac remodeling secondary to chronic volume overload is attenuated by a novel MMP9/2 blocking antibody
Metsada Pasmanik-Chor is not included in the author byline. Metsada Pasmanik-Chor should be listed as the seventh author and affiliated with 4: Bioinformatics Unit, Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel. The contributions of this author are as follows: Formal Analysis, Methodology, Software, Writing–Review and Editing. Citation: Cohen L, Sagi I, Bigelman E, Solomonov I, Aloshin A, Ben-Shoshan J, et al.
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