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Ivana Bozic on Muck Rack

Ivana Bozic

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Articles

Neoantigen evolution and response to checkpoint inhibitor immunotherapy in colorectal cancer

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By Ivana Bozic, Alanna Sholokhova, Kamran Kaveh
| Nature Verified
Abstract Checkpoint-blockade immunotherapy enables the immune system to recognize tumor cells that were previously invisible due to immune escape, but these therapies lead to heterogeneous patient outcomes. Focusing on colorectal cancer, in which two subtypes have markedly different responses to immunotherapy, we query the relationship between a tumor’s mutagenic landscape and therapeutic outcomes.
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Spatiotemporal dynamics of tumor-CAR T-cell interaction following local administration in solid cancers

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By Katherine Owens, Aminur Rahman, Ivana Bozic
| PLOS
Discussion In this work we developed a basic reaction-diffusion model for CAR T-cell treatment of solid tumors and characterized the general behavior of the model in a biologically relevant parameter regime. The underlying mechanism that we use for tumor growth is flexible enough to model a wide range of tumor types. This is particularly valuable as there is significant interest in using CAR technology to treat diverse cancers.
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Early-stage cancer results in a multiplicative increase in cell-free DNA originating from healthy tissue

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By Konstantinos Mamis, Ivana Bozic
| BioRxiv
Abstract Cell-free DNA (cfDNA) is a promising biomarker for cancer detection. However, cfDNA dynamics in the presence of cancer are still poorly understood. Leveraging a rich dataset of cfDNA in healthy individuals and early-stage cancer patients, we find a multiplicative increase in cfDNA concentration in the presence of cancer.
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