Skip To Main Content
Jack Brown on Muck Rack

Jack Brown

As seen in: Nature, The Independent (UK), Taylor & Francis Online, Bored Panda, Patch, Cell Reports, Cell Press, Make:, The Villager (New York, NY), Middle East Eye and
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Jack

Contact Jack, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

TMPRSS2-mediated coronavirus spike activation and inhibition

|
By Matthew McCallum Verified, James Case, Jack Brown, Young-Jun Park, Jimin Lee, Emmajay Sutherland, Anupriya Aggarwal, Cecily Gibson, Florian A. Lempp, Cameron Stewart Verified, M. Alejandra Tortorici, Jun Siong Low, Daniel Asarnow, Dana Bohan, Exequiel Dellota Jr, Bhavna Chawla, Swagata Kar, Antonio Lanzavecchia, Federica Sallusto, Nicholas Riley, Stuart Turville, Lisa A. Purcell, Michael Diamond Verified, David Veesler, Shilpa Sanapala, Benjamin Merz
| Nature Verified
Abstract The protease TMPRSS2 facilitates coronavirus infections, yet its mechanism of viral glycoprotein recognition remains unclear. Here we show that, following ACE2 engagement of the SARS-CoV-2 spike (S) inducing the early fusion intermediate conformation (E-FIC), TMPRSS2 cleaves the R815 S2′ site and promotes fusogenic conformational changes leading to viral entry.
Open in Who Shared Issue with article?

2025 was a year of science breakthroughs

|
By Jack Brown
| The Paris News Verified
As the new year begins, it's a good time to look back on some of the major breakthroughs in science and to consider what the future may hold. In 2025, artificial intelligence made major leaps across many fields, gene-editing technologies moved into real human use, and both mRNA technology and monoclonal antibodies continued their rapid progress.
Open in Who Shared Issue with article?

Secrets of the Thames: Mudlarking London’s Lost Treasures

|
By Jack Brown
| Taylor & Francis Online
Advanced search The London Journal A Review of Metropolitan Society Past and Present Latest Articles Submit an article Journal homepage Full Article Figures & data Citations Metrics Reprints & Permissions Read this article /doi/full/10.1080/03058034.2025.2564586?needAccess=true Click to increase image sizeClick to decrease image size Log in via your institution Access through your institution Log in to Taylor & Francis Online Log in Shibboleth Log in to Taylor & Francis Online Forgot password?
Open in Who Shared View Duplicates (47) Issue with article?
See all 236 licensed articles (248 Total)