Jacob Hawk

Keywords lysosome mitochondrion interferon innate immunity viruses intracellular bacteria damage DNA Introduction Lysosomes are vulnerable to damage by the material they transport. As the endpoint of endocytosis, phagocytosis, and autophagy, these organelles are continually threatened with a barrage of infectious (bacteria, viruses) and non-infectious (particulates, crystals, toxins) insults.

Abstract Lysosomal damage is an endogenous danger signal to the cell, but its significance for innate immunity and how specific signaling pathways are engaged by this stressor remain unclear. Here, we uncover an immune-inducible pathway that connects lysosomal damage to mitochondrial DNA (mtDNA) efflux and type I IFN production.

When my husband and I go to communities to share with prophetic intercessors and church leaders, we are consistently asked about the seeming lack of pastoral support for community prayer. This usually comes up after we talk about the critical role local pastors must play in praying for community and regional breakthrough.