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As seen in: Nature, Wiley Online Library, Journal of Clinical Pathology, BioRxiv, Cell Reports Medicine, Chinese Clinical Oncology, European Journal of Cancer, Lung Cancer
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Articles

Author Correction: SEZ6-targeting antibody−drug conjugate ABBV-706 in advanced small cell lung cancer and solid tumors: a phase 1 trial

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By Lauren Averett Byers, Byoung Chul Cho, Alissa Cooper, Anne C. Chiang, Ji-Youn Han, Muhammad M. Furqan, Afshin Dowlati, Daniel Morgensztern, Kyriakos P. Papadopoulos, Noura J. Choudhury, Maria Vieito, Jair Bar, Joo-Hang Kim, Wallace Akerley, Tae Kim, Young-Chul Kim, Luis Paz-Ares, Myung-Ju Ahn, Hiroshi Yokouchi, Darius Meiman, Wijith Munasinghe, Oluwadamilola Ogunyankin, Nadine S. Jahchan, Song Wang, Cristiano Ferlini, Randy Robinson, Frederick J. Kohlhapp, Tammy Palenski, Guillermo Rivell, Pooja Hingorani, Sreenivasa Chandana
| Nature Verified
Correction to: Nature Medicine https://doi.org/10.1038/s41591-026-04452-0, published online 1 June 2026. In the version of this article initially published, ref. 10 was cited twice and has been replaced by an omitted reference (Faivre E. J. et al. Cancer Res. https://doi.org/10.1158/1538-7445.AM2024-3148 (2024)), now cited as ref.
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SEZ6-targeting antibody−drug conjugate ABBV-706 in advanced small cell lung cancer and solid tumors: a phase 1 trial

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By Lauren Averett Byers, Byoung Chul Cho, Alissa Cooper, Anne C. Chiang, Ji-Youn Han, Muhammad M. Furqan, Afshin Dowlati, Daniel Morgensztern, Kyriakos P. Papadopoulos, Noura J. Choudhury, Maria Vieito, Jair Bar, Joo-Hang Kim, Wallace Akerley, Tae Kim, Young-Chul Kim, Luis Paz-Ares, Myung-Ju Ahn, Hiroshi Yokouchi, Darius Meiman, Wijith Munasinghe, Oluwadamilola Ogunyankin, Nadine S. Jahchan, Song Wang, Cristiano Ferlini, Randy Robinson, Frederick J. Kohlhapp, Tammy Palenski, Guillermo Rivell, Pooja Hingorani, Sreenivasa Chandana
| Nature Verified
Abstract Seizure-related homolog 6 (SEZ6) is expressed in small cell lung cancer (SCLC) and neuroendocrine neoplasms. In an open label, phase 1 trial, ABBV-706, an antibody−drug conjugate with a SEZ6-directed antibody linked to topoisomerase-1 inhibitor (Top1i), was administered intravenously every 3 weeks (Q3W) to 288 patients with advanced solid tumors; 240 received monotherapy, including 124 with relapsed/refractory (R/R) SCLC.
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Lymphodepleting chemotherapy potentiates neoantigen-directed T cell therapy by enhancing antigen presentation

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By Shira Sagie, Tomer Babu, Chen Weller, Ido Livneh, Nele P Quast, Nofar Gumpert, Alina S. Shomuradova, Ronen Levy, Dmitry Malko, Michal Alon, Franco Hessling Herrera, Mikhail Kutuzov, Mirie Zerbib, Polina Greenberg, Gil Benedek, Yishai Levin, Chani Stossel, Iris Kamer, Talia Golan, Roni Oren, Merav D. Shmueli, Osnat Bartok, Jair Bar, Jonathan Cohen, Omer Dushek, Charlotte M. Deane, Yardena Samuels, Claire Tabachnik, Matthew I. Raybould, Adi Alfia, Talal Ben Lulu, Talya Wasserman-Bartov
| Cell Reports Medicine Verified
Results Utilizing our previously developed data-driven pipeline,26 we prioritized candidate neoantigens from The Cancer Genome Atlas (TCGA) lung cancer dataset and identified the KRAS.G12V-HLA-A∗03:01 combination as a leading candidate. This HLA-mutation combination is found in approximately 94,000 patients worldwide (Figure 1A; Table S1).
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