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ArticleOnline nowOpen access Affiliations & Notes 1Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, 94158, United States of America 2UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco, San Francisco, CA, 94158, United States of America 3Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720, United States of America 4Department of Electrical Engineering and...
Computational approaches are necessary to leverage the potential of large datasets and generate new hypotheses. At the same time, testing these predictions in biological systems remains key to truly understanding the underlying mechanisms. Once largely siloed, collaboration between bench and computational work is becoming indispensable for many areas of research.
Abstract Programmable epigenome editors modify gene expression in mammalian cells by altering the local chromatin environment at target loci without inducing DNA breaks. However, the large size of CRISPR-based epigenome editors poses a challenge to their broad use in biomedical research and as future therapies.
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