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Articles by Jared Rutter
How Mitochondria Control Your Metabolism | Dr. Jared Rutter
Dr. Jared Rutter, PhD, Professor of Biochemistry at the University of Utah and Howard Hughes Medical Institute Investigator, is a leading expert on mitochondria and metabolism. He explains how mitochondria produce the energy for your cells to work but also how they regulate cell growth and replication and thereby contribute to health and disease. We also discuss how mitochondria are linked to aging, cancer, and other diseases.
Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis
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Editor’s summary Pulmonary fibrosis has limited therapeutic options, and a better understanding of the underlying biology of the disease could lead to previously unrecognized therapeutic targets. Ziehr et al. investigated monocarboxylate transporters (MCTs) 1 and 4 and their role in myofibroblast differentiation in experimental models of pulmonary fibrosis. In human cell models of pulmonary fibrosis, inhibition of MCT1 or MCT4 reduced myofibroblast differentiation.
By Alka Khaitan, David R. Ziehr, PING LIU, K. Mark Parnell, Nathan M. Krah, Kevin Leahy, Christelle Guillermier, Ce Gao, Sean A. Prell, Niv Vigder, Sergio Poli, Jack Varon, Rebecca M. Baron, Bradley A. Maron, Nancy J. Philp, Lida Hariri, Edy Y. Kim, Kevin S. Wei, Matthew Steinhauser, Rachel Knipe, Jared Rutter, William M. Oldham
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Science Magazine
Verified
RNA-triggered cell killing with CRISPR–Cas12a2
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Abstract Selectively eradicating target cells on the basis of their genetic or transcriptional identity remains important in basic research, medicine, biotechnology and agriculture1,2,3. For applications involving bacteria, CRISPR nucleases offer promising options due to their ability to enact RNA-guided counterselection4,5,6,7; however, using these same nucleases for counterselection in eukaryotes has proven much more restrictive8,9,10,11,12,13,14.
By Paul Scholz, Jared Thompson, Kadin T. Crosby, Torsten Fauth, Nathan M. Krah, Grant Schlauderaff, Robin Back, Zachary A. Berkheimer, Alivia Jolley, Dirk Sombroek, Rebekka Medert, Christian Zurek, Oleg Dmytrenko, Emily Wilson, Friso T. Schut, Jared Rutter, Xiaoyang Zhang, Michael Krohn, Ryan Jackson, Yang Liu
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Nature
Verified
Therapeutic remodeling of the ceramide backbone prevents kidney injury
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Keywords ceramides sphingolipids acute kidney injury proximal tubule metabolism lipid metabolism lipidomics mitochondria MICOS ETC cristae Get full text access Log in, subscribe or purchase for full access. References 1. Cheruku, S.R. ∙ Raphael, J. ∙ Neyra, J.A. ... Acute kidney injury after cardiac surgery: prediction, prevention, and management Anesthesiology. 2023; 139:880-898 2. Hu, J. ∙ Chen, R. ∙ Liu, S. ...
By Rebekah Nicholson, Luis Cedeno-Rosario, J. Alan Maschek, Angela Kruse, Chris Stubben, Liping Wang, Deborah Stuart, Queren A. Alcantara, Monica P. Revelo, Kate Rutter, Xuanchen Wu, Juwan Kim, Juna Ha Kim, Isaac Hall, Amanda Clark, Samir Parikh, Jeffrey M. Spraggins, Donna L. Romero, Jeremy T. Blitzer, Steven Gygi, Jared Rutter, Nirupama Ramkumar, Scott Summers, Trevor Lonergan, Mayette Pahulu, Jacob Taloa
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Cell Metabolism
Verified
Editorial: Insights in diabetes: molecular mechanisms 2022
It gives me great pleasure in writing this invited editorial for the Research Topic in Frontiers in Endocrinology titled “Insights in diabetes: molecular mechanisms 2022.” Considering the fact that diabetic vascular disease is responsible for two- to four-fold increases in the occurrence of coronary artery disease and stroke, and two- to eight-fold increases in the risk of heart failure, I expected several articles relating to the basic cellular and molecular mechanisms and to glucose...
Editorial: Revisiting cellular metabolism and type 1 diabetes
Type 1 diabetes (T1D) is a chronic autoimmune condition characterized by islet inflammation resulting from poorly defined combinations of genetic, metabolic, immunologic, and environmental factors. The pathology elicits profound changes in energy metabolism and mitochondrial function in insulin-deprived conditions of the affected individuals. Several studies point to changes in systemic metabolites other than glucose levels in T1D patients.
Metabolites as signalling molecules - Nature Reviews Molecular Cell Biology
Abstract Traditional views of cellular metabolism imply that it is passively adapted to meet the demands of the cell. It is becoming increasingly clear, however, that metabolites do more than simply supply the substrates for biological processes; they also provide critical signals, either through effects on metabolic pathways or via modulation of other regulatory proteins.
Stressed to death: Mitochondrial stress responses connect respiration and apoptosis in cancer
Anand R. Wai T. Baker M.J. Kladt N. Schauss A.C. Rugarli E. Langer T. The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission. J. Cell Biol. 2014; 204: 919-929https://doi.org/10.1083/jcb.201308006 Endosymbiosis and eukaryotic cell evolution. Curr. Biol. 2015; 25: R911-R921https://doi.org/10.1016/j.cub.2015.07.055 Arnarez C. Marrink S.J. Periole X. Molecular mechanism of cardiolipin-mediated assembly of respiratory chain supercomplexes. Chem. Sci.
Metabolism and the Control of Circadian Rhythms
Annual Review of Biochemistry Vol. 71:307-331 (Volume publication date July 2002) https://doi.org/10.1146/annurev.biochem.71.090501.142857 Jared Rutter Martin Reick and Steven L. McKnight Department of Biochemistry, University of Texas-Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-9152; e-mail: ; ;
A time to build and a time to burn: glucose metabolism for every season
Luengo et al. (2020) Luengo A. Li Z. Gui D.Y. Sullivan L.B. Zagorulya M. Do B.T. Ferreira R. Naamati A. Ali A. Lewis C.A. et al. Increased demand for NAD + relative to ATP drives aerobic glycolysis. Mol. Cell. 2020; 81 ( ) : 691-707 demonstrate that pyruvate dehydrogenase (PDH) overactivation blunts NAD + regeneration by overcharging the mitochondrial membrane potential and driving ATP synthesis beyond demand.
Sweet Sweet Sally Mae AVN
“She’s bad, she’s mean, she’s a lovin’ machine.” And she’s out for revenge. Ricky Greenwood takes us back to the beloved grindhouse realm of Super Fly and , but with a twist: it’s all-girl. First, Misty Stone, with a new braided look, and younger gal pal Sizi Sev, celebrate an infusion of cash from drug runner Sweet Sally Mae (Ana Foxxx). Misty takes the top role and loves Sizi’s sweet ass and lovingly licks her pussy, making her cum and then some.
Impact of Mitochondrial Fatty Acid Synthesis on Mitochondrial Biogenesis
Biology students today are taught that mitochondria are ‘the powerhouse of the cell’. This gross over-simplification of their cellular role has arguably led to a paucity of knowledge concerning the many other tasks carried out by this multifunctional organelle. Mitochondrial fatty acid synthesis (mtFAS) is one such under-appreciated pathway that is crucial for mitochondrial function, although even mitochondrial experts are often surprised to learn of its existence.
Lipid-mediated signals that regulate mitochondrial biology
Lipid-mediated signals that regulate mitochondrial biology Jason R. Nielson‡,§ and Jared P. Rutter‡1 From the Departments of ‡Biochemistry and §Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112 ↵1 To whom correspondence should be addressed. E-mail: rutter{at}biochem.utah.edu. Edited by Ruma Banerjee Abstract For decades, lipids were assumed to fulfill roles only in energy storage and membrane structure.
Lipid-mediated signals that regulate mitochondrial biology
For decades, lipids were assumed to fulfill roles only in energy storage and membrane structure. Recent studies have discovered critical roles for phospholipids, sphingolipids, and sterols in many cellular pathways, including cell signaling and transcriptional regulation. Frequently, lipids from these various classes work together to achieve defined cellular outcomes.
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