Nov. 10, 2025 – By Jim McGregor, Contributor, for Tirias Research Discussions about CPUs often frame one instruction set architecture (ISA) against another—x86 vs. Arm, Arm vs. RISC-V, and so on. However, it’s common to use multiple CPU architectures in a single system, whether that is a single system-on-chip (SoC) or a larger electronics platform, like a PC, car or even a data center.