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Articles by Jin Lu
The oral–lung axis in lung cancer: microbial translocation, immune reprogramming, and clinical implications
Abstract The oral–lung axis describes microbial and inflammatory exchange between the oral cavity and the lower respiratory tract. Its relevance to lung cancer is supported by the detection of oral-associated taxa in lower-airway samples, epidemiological links between periodontal disease and lung cancer risk, and experimental evidence that microbial signals can modify epithelial proliferation and antitumor immunity.
Emotional and behavioral problems in children of parents with severe mental illness in Wuhan, China: the roles of child maltreatment and exposure to parental victimization
Abstract Guided by a developmental-ecological and trauma-informed framework, children of parents with severe mental illness (SMI) may develop emotional and behavioral problems (EBPs) through inherited vulnerability, disrupted caregiving, socioeconomic adversity, stigma, and trauma-related exposures. However, the roles of direct trauma (child maltreatment, operationalized here as emotional and physical abuse) and indirect trauma (exposure to parental victimization) remain poorly understood.
Mindfulness as a mediator of the relationship between childhood maltreatment and school bullying involvement
Abstract Childhood maltreatment (CM) is a major public health concern that substantially raises the risk of adolescent school bullying. While mindfulness alleviates trauma-related distress by enhancing emotional regulation, its mediating effect on the link between maltreatment and bullying remains poorly understood. This cross-sectional study recruited 27,530 adolescents aged 10–17 years. Multilevel logistic regression and structural equation modeling were applied.
Circulating tumor DNA in lung cancer immunotherapy: prognostic marker today, predictive tool tomorrow?
Abstract Circulating tumor DNA (ctDNA) is emerging as a minimally invasive biomarker for risk stratification and treatment-response assessment in lung cancer immunotherapy, but its routine use for treatment selection has not been established.
Low-dose baricitinib plus danazol in primary immune thrombocytopenia: a randomized, controlled phase 2 trial
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Abstract This multicenter, randomized, controlled study was conducted to explore the safety and efficacy of low-dose baricitinib plus danazol for ITP patients who had failed corticosteroids and at least one recommended subsequent treatment. Participants were randomly assigned to receive baricitinib plus danazol (n = 108) or danazol alone (n = 108) by a central, interactive web-based system. Patients and caregivers were not blinded to group assignment.
By Peng Zhao, Zhuo-Yu An, Hai-Xia Fu, Yang Wang, Hui-Xin Liu, Dai-Hong Liu, Yi Liu, Zhao Wang, Yu-jun Dong, Hong-Mei Jing, Li-Hong Li, Qiu-Sha Huang, Jin Wu Verified, Li-Ping Yang, Yue Jin, Chen-Cong Wang, Qi Chen, Xiao-Lu Zhu, Yun He, Yuan-Yuan Zhang, Qian Jiang, Hao Jiang, Jin Lu, Ying-Jun Chang, Xiang-Yu Zhao, Xiao-Jun Huang, Xiao-Hui Zhang, Guo-Shuang Feng, He-Bing Zhou, Zhen-Ling Li, Li-Ping Dou, Zhi-Xue Li
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Nature
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Effect of Electroacupuncture on Postherpetic Neuralgia : A Randomized Clinical Trial
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Effect of Electroacupuncture on Postherpetic Neuralgia: A Randomized Clinical Trial Supplement 1. Supplement 2. eTable 1. Location of Acupoints for EA and SA Groups eTable 2. Baseline Characteristics of Participants from the Interim Analysis eTable 3. Quantitative Outcomes at Time Points from the Interim Analysis eTable 4. Adverse Events Related to Treatment from the Interim Analysis eTable 5. Primary Outcome and Secondary Outcomes eTable 6. Verbal Rating Scale at Each Visit Time eTable 7.
By LU CHEN, Qianyan Liu, Lixia Pei, Hao Geng, Yongtao Liu, Zhengming Yang, Min Ding, Rongrong Shen, Min Chen, Jin Lu, Dongfang You, Xiaoliang Wu, Junling Zhou, Linyan Hu, Benjie Guo, Shuting Sun, Feiyi Chen, Zhanhao Zhao, Yining Zhai, Zhuolin Chen, Zhenan Li, Wenping Yao, Hua Feng, Chunxia Lu, Yanfang Liu, Juanjuan Shi, Jing Guo, Jianhua Sun
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JAMA Network
Verified
Camrelizumab Plus Famitinib in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: A Phase 2 Study
1 Introduction Most patients with head and neck squamous cell carcinoma (HNSCC) present with locally advanced disease at diagnosis and are treated with surgery, definitive (chemo)radiation, or platinum-based chemotherapy [1]. Despite ongoing advancements in surgical techniques and chemotherapeutic strategies, the prognosis for most patients with advanced disease remains poor [2].
First Day of Musk’s Lawsuit Against Altman: “No Me, No OpenAI”
At the heart of this trial lies an AI giant valued at over $1 trillion—and the complete collapse of trust between two former friends. By: Jin Lu Edited by: Boyang On April 28, U.S. time, Elon Musk’s lawsuit against OpenAI commenced in the U.S. District Court for the Northern District of California in Oakland. Musk appeared as the first witness, attempting to explain to the nine-member jury why he originally intended OpenAI to be a nonprofit organization.
Diagnostic accuracy of digital clock drawing test for Alzheimer disease and mild cognitive impairment
Abstract Alzheimer’s disease (AD) and mild cognitive impairment (MCI) are major public health concerns, requiring accurate and scalable diagnostic tools. The digital clock drawing test (dCDT) captures drawing data and enables extraction of process-related features that may improve diagnostic performance. However, existing evidence remains inconsistent, highlighting the need for a systematic synthesis to support its clinical translation.
Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individualse
What is already known about this subject The prescription of GABA-A receptor agonists for insomnia is associated with adverse effects including dependence, cognitive impairment and an increased risk of falls, particularly in elderly patients. Fazamorexant is a novel dual orexin receptor antagonist currently in development for insomnia treatment. However, its age-dependent pharmacokinetics and pharmacodynamics profiles remain.
Changes in the composition of immune cells in the tumor microenvironment of MMTV-PyMT breast cancer mice at different ages
Abstract: Objective This study aimed to investigate the tumorigenic properties of MMTV-PyMT breast cancer transgenic mice at different ages (in weeks) and the changes in the composition of immune cells in the tumor microenvironment.
Risk factors for postoperative delirium in orthopedic surgery patients: a systematic review and meta-analysis
?Mathematical formulae have been encoded as MathML and are displayed in this HTML version using MathJax in order to improve their display. Uncheck the box to turn MathJax off. This feature requires Javascript. Click on a formula to zoom. Abstract Background Postoperative delirium is a common and serious complication in orthopedic surgery patients, particularly in the elderly.
A Dengue Fever Epidemiological Model With Vaccination and Vaccine Inefficacy
The global impact of dengue has prompted the development of numerous mathematical models aimed at understanding and controlling the pandemic. The Qdenga vaccine was introduced in 2022 to prevent dengue infection. Building on this, we develop a threshold-based dynamical model of the dengue fever epidemic that incorporates vaccination, vaccine inefficacy, and asymptomatic carriers.
Case Report: A pharmacist-led precision therapy framework for managing invasive fungal infection in CSF1R-Related leukoencephalopathy post Allo-HSCT
CASE REPORT article Volume 16 - 2025 | https://doi.org/10.3389/fphar.2025.1656503 This article is part of the Research TopicResearch on Precision Prevention and Treatment of Neurological and Neurodegenerative DiseasesView all 18 articles Highlights • This case presents the first reported CSF1R-related leukoencephalopathy with a non-hotspot c.2443-1G>C mutation complicated by invasive fungal infection after allo-HSCT.
Heat Transfer Mechanism Model for Elongated Bubble Growth in Non-Circular Microchannels
ABSTRACT Based on the study of two-phase flow boiling heat transfer characteristics in rectangular microchannels, this paper proposes a novel mechanistic model for accurately predicting the heat transfer coefficient (HTC) in microchannels.
Effects of Glyphosate on Zebrafish (Danio rerio) Developmental Toxicity
Conflicts of Interest The authors declare no conflicts of interest. References 1 and , “Glyphosate: Environmental Contamination, Toxicity and Potential Risks to Human Health via Food Contamination,” Environmental Science and Pollution Research International 23, no. 19 (2016): 18988–19001. 2, “The History and Current Status of Glyphosate,” Pest Management Science 74, no. 5 (2018): 1027–1034.
Impact of Pulsed Electric Fields Combined with Dissolved Oxygen and Ferrous Ions on the Aroma and Components of Strong-Flavor Baijiu
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Single-molecule electrochemical imaging of ‘split waves’ in the electrocatalytic (EC′) mechanism
Single-molecule electrochemical imaging of ‘split waves’ in the electrocatalytic (EC′) mechanism† We describe a single-molecule electrochemical imaging strategy to study the electrocatalytic (EC′) mechanism. Using the fluorescent molecule ATTO647N at extremely low concentrations as the substrate, we confirmed its catalytic reduction to a nonfluorescent form in the presence of the mediator phenazine methosulfate (PMS) by imaging and counting fluorescent molecules.
An Unbiased Feature Estimation Network for Few-Shot Fine-Grained Image Classification
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Creditor litigation and corporate innovation: Evidence from China
Supporting Information Filename Description acfi13364-sup-0001-AppendixS1-S2.docxWord 2007 document , 18.4 KB Appendix S1. REFERENCES (1968) Financial ratios, discriminant analysis and the prediction of corporate bankruptcy. The Journal of Finance, 23, 589–609. , & (2013) Credit supply and corporate innovation. Journal of Financial Economics, 109(3), 835–855. & (2015) The effects of securities class action litigation on corporate liquidity and investment policy.
Subsequent Pregnancy Outcomes Following Prepregnancy Cerclage in Patients with Absent Ecto Cervix
1. Alfirevic Z, Stampalija T, Medley N (2017). Cervical stitch (cerclage) for preventing preterm birth in singleton pregnancy. Cochrane Database Syst Rev, 6: CD008991. 2. Shennan A, Story L, Jacobsson B, Grobman WA (2021). FIGO Working Group for Preterm Birth (2021). FIGO good practice recommendations on cervical cerclage for prevention of preterm birth. Int J Gynaecol Obstet, 155(1): 19-22. 3. Sundtoft I, Langhoff-Roos J, Sandager P, et al (2017).
Salp Swarm Algorithm-Based Kalman Filter for Seamless Multi-Source Fusion Positioning with Global Positioning System/Inertial Navigation System/Smartphones
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Single-molecule electrochemical imaging of 'split waves' in the electrocatalytic (EC') mechanism
Single-molecule electrochemical imaging of 'split waves' in the electrocatalytic (EC') mechanism We describe a single-molecule electrochemical imaging strategy to study the electrocatalytic (EC') mechanism. Using the fluorescent molecule ATTO647N at extremely low concentrations as the substrate, we confirmed its catalytic reduction to a nonfluorescence form in the presence of the mediator phenazine methosulfate (PMS) by imaging and counting fluorescent molecules.
High-Dimensional Spectral Analysis of Natural Killer Cell Alterations Identifies a Subgroup with an Enhanced Daratumumab Treatment Response in Relapsed and Refractory Multiple Myeloma
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 23 May 2024 / Approved: 23 May 2024 / Online: 23 May 2024 (12:34:34 CEST) Cao, X.; Dou, X.; Wen, L.; Huang, X.; Lu, J.; Zhao, X. High-Dimensional Spectral Analysis of Natural Killer Cell Alterations Identifies a Subgroup with an Enhanced Daratumumab Treatment Response in Relapsed and Refractory Multiple Myeloma. Preprints 2024, 2024051516.
Atmosphere | Free Full-Text | Analysis of Three Dimethyl Sulfides in Freshwater Lakes Using Headspace Solid-Phase Microextraction-Gas Chromatography with Flame Photometric Detection
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
A face retrieval technique combining large models and artificial neural networks
CONFLICT OF INTEREST STATEMENT The author declares no conflicts of interest. REFERENCES 1, , . Actions in context. 2009 IEEE Conference on Computer Vision and Pattern Recognition. IEEE; 2009: 2929-2936. 2, , . Using the forest to see the trees: object recognition in context. Commun ACM. 2010; 53: 107-114. 3, , . Recent advance in content-based image retrieval: a literature survey. arXiv preprint arXiv:1706.06064. 2017. 4, , . Dual attention networks for multimodal reasoning and matching.
VT Women Basketball vs GT
While the heart of Blacksburg resides in Virginia Tech’s campus, the town offers unique experiences that leave locals and visitors in awe of its charm. As students come back from winter break, there are many opportunities for every individual to explore their interests. Here are a few popula…
Rotational Stiffness Investigation and Parametric Analysis of a Novel Assembled Joint in Lattice Shells
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Spinetoram-Induced Potential Neurotoxicity through Autophagy Mediated by Mitochondrial Damage
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Single-Molecule Electrochemical Imaging Resolves the Midpoint Potentials of Individual Fluorophores on Nanoporous Antimony-Doped Tin Oxide
Single-Molecule Electrochemical Imaging Resolves the Midpoint Potentials of Individual Fluorophores on Nanoporous Antimony-Doped Tin Oxide We report reversible switching of oxazine, cyanine, and rhodamine dyes by a nanoporous antimony-doped tin oxide electrode that enables single-molecule (SM) imaging of electrochemical activity.
Design and Experiment of Bionic Straw-Cutting Blades Based on Locusta Migratoria Manilensis
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Track-Before-Detect Algorithm Based on Cost-Reference Particle Filter Bank for Weak Target Detection
CCBY - IEEE is not the copyright holder of this material. Please follow the instructions via https://creativecommons.org/licenses/by/4.0/ to obtain full-text articles and stipulations in the API documentation. Detecting weak target with low signal to noise ration (SNR) is crucial in many applications. However, conventional detect-before-track (DBT) approach [1], [2] is invalid in this case.
Treatment Rates for Mental Disorders Among Children and Adolescents
Key Points Question What are the treatment rates for mental disorders among children and adolescents? Findings In this meta-analysis of 40 studies including 310 584 children and adolescents, the combined treatment rate was 38% (95% CI, 30%-45%) for any mental disorder, 36% (95% CI, 29%-43%) for depressive disorders, 31% (95% CI, 21%-42%) for anxiety disorders, 58% (95% CI, 42%-73%) for attention-deficit/hyperactivity disorder, and 49% for behavior disorders (95% CI, 35%-64%).
Engineering gain‐of‐function mutants of a WW domain by dynamics and structural analysis
Supporting Information Filename Description pro4759-sup-0001-Figures.docxWord 2007 document , 2 MB Figure S1: Docked state of mutant residues on the N21 background(left). Sequences of the newly designed WW domain variants with mutations are highlighted in red(right). Figure S2: SEC chromatogram to check possible dimerization at the concentrations used in ITC. Superdex 30 Increase 10/300 GL column was used in AKTApure and calibrated using appropriate standards (inset).
Age-related effect of uric acid on CI-AKI following CAG
Back to Journals » Clinical Interventions in Aging » Volume 18 Authors Lu J, He Y, Yang Y, Zhong X, Chen S, Wu B, Pan Y, Wang Y, Xiu J, Kang Y, Liu J, Liu Y, Chen S, Chen K, Chen L Received 29 April 2023 Accepted for publication 8 November 2023 Published 7 December 2023 Volume 2023:18 Pages 2053—2061 DOI https://doi.org/10.2147/CIA.S419370 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Maddalena Illario Jin...
亚帆中心：一半是陆地，一半在海中_The_sea_Sailing
原标题：亚帆中心：一半是陆地，一半在海中 The Asia Sailing Center. /亚帆中心。[Photo by Xu Neng] 徐能 摄 By Jin Lu Located in the Songlan Mountain tourist resort of Xiangshan County in Ningbo, the Asian Sailing Center is the only competition venue of the Hangzhou Asian Games that involves marine construction. Half of the center is on land and the other half is in the sea, and the combined design of sea and land integrates the competition with nature.
Campus Voices Interpreting the 20^th National Congress of the CPC
Faculties and students pose for photograph during the lecture. [Photo provided by Yu Yingzhuo] In response to the 20^th National Congress of the Communist Party of China, Ningbo University has been active in the research, promotion and dissemination of the Congress's guiding principles. The University's Faculty of Foreign Languages and International College and Academy of Eastern Zhejiang Culture recently organized several thematic events to provide deeper insight into the Congress.
LncRNA LINC00665 Promotes Ovarian Cancer Cell Proliferation and Inhibits Apoptosis via Targeting miR-181a-5p/FHDC.
Previous reports indicate that long intergenic non-coding RNA LINC00665 naturally occurred vital effects in various cancers. Herein, the role of LINC00665 in ovarian cancer progress was explored. We found that LINC00665 was upregulated in ovarian cancer cell lines.
Dipole-spread-function engineering for simultaneously measuring the 3D orientations and 3D positions of fluorescent molecules
Abstract Interactions between biomolecules are characterized by where they occur and how they are organized, e.g., the alignment of lipid molecules to form a membrane. However, spatial and angular information are mixed within the image of a fluorescent molecule–the microscope’s dipole-spread function (DSF). We demonstrate the pixOL algorithm to simultaneously optimize all pixels within a phase mask to produce an engineered Green’s tensor–the dipole extension of point-spread function engineering.
Điểm qua 5 trang phục ngủ thời thượng “hot” nhất 2022 - Thời trang - Tin trong ngày
Khi phái đẹp bắt đầu chăm chút đến bản thân nhiều hơn cũng là lúc mà các trang phục ngủ dần lên ngôi. Đó cũng chính là lúc mà bạn nên thay đổi những bộ đồ ngủ nhàm chán, bằng thời trang ở nhà sành điệu. Hiểu được điều đó, thương hiệu thời trang Vincy đã gợi ý top 5 trang phục ngủ thời thượng đang được nhiều quý cô săn đón. Cùng chúng tôi điểm qua những trang phục này là gì nhé! Thiết kế veston dành riêng cho phụ nữ hiện đại Vest mặc đi ngủ có thoải mái không?
RESEARCH ARTICLE Ming Chu, Ming Chu Laboratory of Life and Health Sciences, Shenzhen First Union Technology Co., Ltd, Shenzhen, China Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China...
Prevalence of depressive disorders and treatment in China: a cross-sectional epidemiological study
Summary Background In China, depressive disorders have been estimated to be the second leading cause of years lived with disability. However, nationally representative epidemiological data for depressive disorders, in particular use of mental health services by adults with these disorders, are unavailable in China.
Risk factors on admission associated with hospital length of stay in patients with COVID-19: a retrospective cohort study
Abstract Treating patients with COVID-19 is expensive, thus it is essential to identify factors on admission associated with hospital length of stay (LOS) and provide a risk assessment for clinical treatment. To address this, we conduct a retrospective study, which involved patients with laboratory-confirmed COVID-19 infection in Hefei, China and being discharged between January 20 2020 and March 16 2020.
Linoleic Acid-Derived Carbon Microspheres with Hierarchical Porous Structure and Controllable Surface Groups toward Application in Supercapacitors
Hierarchical porous carbons (HPCs) with optimized porosity and enriched surface functional groups are a promising carbon material for supercapacitor development. However, it is a challenge to realize the selective regulation of surface functional groups. In this study, the HPCs with enriched carbonyl (C═O) and carboxyl (O–C═O) groups were prepared from linoleic acid by using the carbonization under autogenic pressure at elevated temperatures (CAPET) method followed by KOH activation.
Well-Aligned Ni-Heteroatom (N, S) MOF Arrays Enhanced Electrocatalytic Oxygen Evolution Reaction
Download Hi-Res ImageDownload to MS-PowerPointCite This:Inorg. Chem. 2021, 60, 3 RETURN TO ISSUEPREVCommunicationNEXT Du Yu Du Yu Deep-processing of Fine Flake Graphite Sichuan Province Key Laboratory of Colleges and Universities, Panzhihua University, Panzhihua, Sichuan 617000, P. R. China , Zhi-Qiang Jiang* Zhi-Qiang Jiang Deep-processing of Fine Flake Graphite Sichuan Province Key Laboratory of Colleges and Universities, Panzhihua University, Panzhihua, Sichuan 617000, P. R.
Single‐Molecule 3D Orientation Imaging Reveals Nanoscale Compositional Heterogeneity in Lipid Membranes
Cover Picture Hesam Mazidi Department of Electrical and Systems Engineering, Center for Science and Engineering of Living Systems, Institute of Materials Science and Engineering, Washington University in St. Louis, St. Louis, MO, 63130 USA Search for more papers by this author Prof. Matthew D.
Single‐Molecule 3D Orientation Imaging Reveals Nanoscale Compositional Heterogeneity in Lipid Membranes
Research Article Hesam Mazidi Department of Electrical and Systems Engineering, Center for Science and Engineering of Living Systems, Institute of Materials Science and Engineering, Washington University in St. Louis, St. Louis, MO, 63130 USA Search for more papers by this author Prof. Matthew D.
Prevalence and correlates of suicide attempt among Chinese individuals receiving methadone maintenance treatment for heroin dependence
Abstract To date, there have been very limited studies regarding the clinical epidemiology of attempted suicide in Chinese individuals with heroin-dependence. The objective of this study was to examine the prevalence and correlates of suicide attempt in Chinese individuals receiving methadone maintenance treatment for heroin dependence.
Cost-effectiveness of lenalidomide plus low-dose dexamethasone for newly diagnosed multiple myeloma patients ineligible for stem cell transplantation in China | Journal of Comparative Effectiveness Research
Metrics Downloaded 0 times History Received 21 April 2019 Accepted 10 June 2019 Published online 24 June 2019 Information © 2019 Future Medicine Ltd KeywordsAuthor contributions J Lu formulated research idea and developed the study protocol. W Chen constructed the model structure, identified the data sources for the estimations of model variables and conducted the cost–effectiveness analysis. J Lu and W Chen were fully involved with the development of this manuscript.
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