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Articles by Jonathan Grigg
Oral bacterial lysate treatment for prevention of recurrent wheeze following severe bronchiolitis: protocol for an international multicentre randomised, placebo-controlled trial (BLIPA)
Abstract Bronchiolitis is a common condition caused by a viral acute lower respiratory infection (ALRI) in infants. Severe bronchiolitis requiring hospitalisation is associated with increased risk of preschool wheeze and school-age asthma. Early exposure to microbial products modulating immune system development may help prevent later wheeze. Thus, this study evaluates whether an oral bacterial lysate after bronchiolitis hospitalisation reduces subsequent wheezing episodes.
Good research conduct: an update
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Pharmacokinetics and safety of tezepelumab in children with mild, moderate or severe asthma and adolescents with mild-to-moderate asthma
1 What is already known about this subject Tezepelumab is a monoclonal antibody that inhibits thymic stromal lymphopoietin, a key cytokine in asthma pathogenesis. Although tezepelumab is approved for adolescents and adults with severe, uncontrolled asthma, its pharmacokinetics (PK), pharmacodynamics and safety profile in younger children remained to be established.
Damp and mouldy home: impact on lung health in childhood
Damp and mouldy home: impact on lung health in childhood Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways. View Full Text Read the full text or download the PDF: Read the full text or download the PDF:
European Respiratory Society Research Seminar on Preventing Pediatric Asthma
Conflicts of Interest The research seminar was supported by a grant from the European Respiratory Society. J.G. Support; NIHR Senior Investigator Award, Grants; OM Pharma, Marinomed; Advisory board; OM Pharma, Omron, Honoraria; AstraZeneca, Equipment and materials donation; OM Pharma, Immunotek S.L., Omron, Payment for medical evidence; Hogg Robertson Solicitors. K.B. Honoraria; Sanofi and AstraZeneca, Meeting support; ALK-Abelló Nordic, Advisory Board; ALK-Abelló Nordic.
Outdoor air pollution and near‐fatal/fatal asthma attacks in children: A systematic review
1 INTRODUCTION Asthma affects over 300 million people globally. An asthma attack occurs when a trigger such as a virus, airborne allergens or air pollution causes an inflammatory response resulting in bronchoconstriction of small airways. Asthma attacks range in severity from mild to fatal.
Environmental Health, Asthma and Allergy Prevention
Asthma is an inflammatory disease of the airways of the lungs. It is not one disease but a syndrome consisting of many so far not well-characterized and delineated genetic and environmental determinants. The focus of our work at the Institute of Asthma and Allergy Prevention (IAP) is to develop novel asthma and allergy prevention strategies and characterize in-depth asthma phenotypes. Asthma is an inflammatory disease of the airways of the lungs.
European Respiratory Society statement on novel nicotine and tobacco products, their role in tobacco control and “harm reduction”
Footnotes This manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.
Clinical efficacy and satisfaction of a digital wheeze detector in a multicentre randomised controlled trial: the WheezeScan study
Introduction Wheezing caused by viral infections is common among preschool children, with up to 50% experiencing at least one wheezing episode in the first 6 years of their life [1, 2]. Studies have shown that children suffering from wheeze, especially persistent phenotypes, have a higher risk of developing asthma later in childhood [3]. The main treatment goals for preschool wheezing are respiratory symptom control, reduction of exacerbations and increasing quality of life for the child [4].
Statement on Tobacco 21 from the European Respiratory Society Tobacco Control Committee
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Smoking, nicotine, and COVID-19
Scientific journals rightly responded to the SARS-CoV-2 pandemic by more rapidly publishing their COVID-19 research. For the most part, the speeding up of time from review to publication and lowering of publication thresholds for COVID-19 research has been beneficial. But, in some cases the significant limitations of this rapidly disseminated knowledge were not sufficiently made apparent.
Exposure to Particulate Matter Increases Expression of the Angiotensin converting enzyme-2 (ACE2) Receptor
The mechanism by which SARS-CoV-2 enter host cells is via the ACE2 receptor. Previous studies have reported an association between exposure to air pollution and vulnerability to COVID-19 infection [1]. In mice, ACE2 expression is increased in pulmonary epithelial cells following instillation of particulate matter (PM) [2]. It has been suggested that nasal epithelial cells may be the primary access point for SARS-CoV-2 [3].
Should e-cigarettes be licensed as medicines?
News & Views Should e-cigarettes be... Should e-cigarettes be licensed as medicines?
Personal monitoring to reduce exposure to black carbon in children with asthma; a pilot study
Abstract Using an advice-based intervention in a cohort of children with asthma, designed to reduce personal pollution exposure, we found a mean reduction in black carbon exposure of 34%, this was mainly driven by home environment strategies. Footnotes This manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team.
Personal monitoring to reduce exposure to black carbon in children with asthma: a pilot study
Lee Koh, Jonathan Grigg, Abigail Whitehouse ERJ Open Research 2021 7: 00482-2021; DOI: 10.1183/23120541.00482-2021 Abstract Using an advice-based intervention in a cohort of children with asthma, designed to reduce personal pollution exposure, a mean reduction in black carbon exposure of 34% was found, the primary reduction happening within the home environment https://bit.ly/301Xemt To the Editor: In December 2020, Her Majesty's Assistant Coroner for Inner South London, UK, Philip Barlow,...
The presence of air pollution particulate matter in cryopreserved placental tissue cells
Norrice M. Liu, Yehao Chen, Lisa Miyashita, Wing Hung Tam, Noelle A. Ngai, Jonathan Grigg, Ting Fan Leung ERJ Open Research 2021 7: 00349-2021; DOI: 10.1183/23120541.00349-2021 Abstract Carbonaceous particles seen in frozen human macrophage-enriched placental cells can be used as a biomarker of personal exposure to combustion-derived particulate matter. The feasibility of using frozen tissues will allow for global comparative studies.
Advanced glycation end products and wheeze: a plausible association?
Advanced glycation end products and wheeze: a plausible association?
Tobacco control and the ERS: new problems and old foes
Tobacco control and the ERS: new problems and old foes Jonathan Grigg European Respiratory Journal Jan 2021, 57 (1) 2003499; DOI: 10.1183/13993003.03499-2020
Advanced glycation end products and wheeze: a plausible association?
Advanced glycation end products and wheeze: a plausible association?
Differential association of air pollution exposure with neonatal and postneonatal mortality in England and Wales: A cohort study
Loading metrics Open Access Peer-reviewed Research Article Sarah J. Kotecha , W. John Watkins , John Lowe, Jonathan Grigg, Sailesh Kotecha Sarah J. Kotecha, W. John Watkins, John Lowe, Jonathan Grigg, Sailesh Kotecha Published: October 20, 2020 https://doi.org/10.1371/journal.pmed.1003400 Figures Abstract Background Many but not all studies suggest an association between air pollution exposure and infant mortality.
World No Tobacco Day: smoking, nicotine and children
Jørgen Vestbo, Jonathan Grigg, Charlotta Pisinger, Andy Bush European Respiratory Journal 2020 55: 2001633; DOI: 10.1183/13993003.01633-2020 Abstract In line with @WHO, @EuroRespSoc will work to protect children from being addicted to smoking and nicotine use https://bit.ly/3fNpVas 31 May, 2020 is World Health Organization (WHO) World No Tobacco Day. The theme this year is “Protecting youth from industry manipulation and preventing them from tobacco and nicotine use” [1].
E cigarettes: Tar Wars: The (Tobacco) Empire Strikes Back
E cigarettes: Tar Wars: The (Tobacco) Empire Strikes Back Free Andy Bush1, Jayesh Bhatt2, Jonathan Grigg3 1 Paediatric Respiratory Medicine, Royal Brompton and Harefield NHS Foundation Trust, London, UK 2 Respiratory Paediatrics, Nottingham Children’s Hospital, Nottingham, UK 3 Academic Division of Paediatrics, Centre for Child Health, Blizard Institute, Queen Mary University of London, London, UK Correspondence to Professor Andy Bush, Department of Paediatric Respiratory Medicine, Royal...
E-cigarette regulation: getting it wrong costs lives
FREE with registration! Log in or register to access the full article. References 1. Kim, HJ ∙ Lee, MS ∙ Hong, SB ∙ et al. A cluster of lung injury cases associated with home humidifier use: an epidemiological investigation Thorax. 2014; 69:703-708 2. Lee, JH ∙ Kim, YH ∙ Kwon, JH Fatal misuse of humidifier disinfectants in Korea: importance of screening risk assessment and implications for management of chemicals in consumer products Environ Sci Technol. 2012; 46:2498-2500 3.
E cigarettes: Tar Wars: The (Tobacco) Empire Strikes Back
E cigarettes: Tar Wars: The (Tobacco) Empire Strikes Back Free Andy Bush1, Jayesh Bhatt2, Jonathan Grigg3 1 Paediatric Respiratory Medicine, Royal Brompton and Harefield NHS Foundation Trust, London, UK 2 Respiratory Paediatrics, Nottingham Children’s Hospital, Nottingham, UK 3 Academic Division of Paediatrics, Centre for Child Health, Blizard Institute, Queen Mary University of London, London, UK Correspondence to Professor Andy Bush, Department of Paediatric Respiratory Medicine, Royal...
E cigarettes: Tar Wars: The (Tobacco) Empire Strikes Back
Students of mythology will recollect that the second Labour of Hercules was to fight Lernaean Hydra, a nine-headed monster with the endearing habit of growing two ferocious heads to replace each one that was cut-off. Autres temps—conventional cigarettes may be on the way out as legislators (although some rather reluctantly) have tightened the noose, with a rich yield of health benefits for children,1 2 but the new Hydra-head of vaping and other means of inhaling nicotine have come on the scene.
Leading article on e-cigarettes. Tar wars: the (tobacco) empire strikes back
Students of mythology will recollect that the second Labour of Hercules was to fight Lernaean Hydra, a nine-headed monster with the endearing habit of growing two ferocious heads to replace each one that was cut-off. Autres temps—conventional cigarettes may be on the way out as legislators (although some rather reluctantly) have tightened the noose, with a rich yield of health benefits for children,1 2 but the new Hydra-head of vaping and other means of inhaling nicotine have come on the scene.
Electronic cigarette vapour enhances pneumococcal adherence to airway epithelial cells under abnormal conditions of exposure
ExtractM. Caruso and co-workers raise several points related to our electronic cigarette (EC) study [1]. First, they suggest that we generated EC vapour (ECV) under “extreme” experimental conditions, which could lead to overheating and thermal decomposition of E-liquids around a heated coil [2].
Preschool wheeze, genes and treatment
Effect of foetal and infant growth and body composition on respiratory outcomes in preterm-born children
In control of ambient and household air pollution - how low should we go?
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. FiguresThe Lancet Commission on Pollution and Health is a robust call to arms.
Still failing to tackle air pollution
After much delay, and only after a court order, on 26 July the UK government published a plan to tackle the scandal of Britain’s illegal and dirty air.1 Cities in Britain now regularly breach safety standards because of air pollution caused by traffic, in particular by diesel powered vehicles.
Arrhythmias and particulate matter
There is strong epidemiological evidence that inhalation of combustion-derived soot triggers life-threatening cardiovascular events. Indeed, the 2015 Global Burden of Disease estimated that 1 521 000 (35%) of the total of 4 241 000 deaths attributable to ambient particulate matter (PM; all causes) were from ischaemic heart disease.
The Journal of Pediatrics
Urinary prostanoids in preschool wheeze
Urinary prostanoids in preschool wheeze Jonathan Grigg, Abigail Whitehouse, Hitesh Pandya, Stephen Turner, Christopher J. Griffiths, Tom Vulliamy, Robert T. Walton, David B. Price, Marek Sanak, John W. Holloway, Lee Noimark, Maia Lesosky, Rossa Brugha, Lee Koh, Chinedu Nwokoro European Respiratory Journal Feb 2017, 49 (2) 1601390; DOI: 10.1183/13993003.01390-2016
Tiotropium in paediatric asthma
AbstractNo significant benefit of inhaled tiotropium was found in a trial in children and young people with severe asthma http://ow.ly/jmK1306ck1NThe emerging evidence that there are many types of asthma that may respond differently to treatment suggests a need for novel inhaled therapies beyond the current armamentarium of short-acting ?2-agonists, long-acting ?2-agonists (LABA) and inhaled corticosteroids (ICS).
Urinary prostanoids in preschool wheeze
Urinary prostanoids in preschool wheeze Jonathan Grigg, Abigail Whitehouse, Hitesh Pandya, Stephen Turner, Christopher J. Griffiths, Tom Vulliamy, Robert T. Walton, David B. Price, Marek Sanak, John W. Holloway, Lee Noimark, Maia Lesosky, Rossa Brugha, Lee Koh, Chinedu Nwokoro European Respiratory Journal Dec 2016, 1601390; DOI: 10.1183/13993003.01390-2016
Exposure to welding fume and oxidative stress in airway epithelial cells
AbstractBackground: Exposure of cells to particulate matter (PM) causes oxidative stress. This can trigger inflammation and downstream tissue damage. Welding fumes, a type of PM, have been shown to cause oxidative stress in lower airway epithelial cells and occupational exposure to welding fumes causes oxidative stress in welders. Little is known about the molecular mechanisms involved in the cellular response to oxidative stress after exposure to welding fumes.
Effect of E-cigarette vapour on susceptibility to S. pneumoniae infection
Effect of E-cigarette vapour on susceptibility to S. pneumoniae infection Lisa Miyashita, Reetika Suri, Richard van Zyl-Smit, Jonathan Grigg European Respiratory Journal Sep 2016, 48 (suppl 60) PA2020; DOI: 10.1183/13993003.congress-2016.PA2020
Does modelled exposure of children to particulate matter air pollution for the school address reflect personal exposure to black carbon?
Does modelled exposure of children to particulate matter air pollution for the school address reflect personal exposure to black carbon? Abigail Whitehouse, Benjamin Barratt, Jonathan Grigg European Respiratory Journal Sep 2016, 48 (suppl 60) PA1320; DOI: 10.1183/13993003.congress-2016.PA1320
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