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Articles by Julia Sinclair
Brain network-based stratification of mental health disorders: design and cohort description of the STRATIFY and ESTRA studies
Abstract The STRATIFY (Brain Network-Based Stratification of Reinforcement-Related Disorders) and ESTRA (Eating Disorders Stratification) studies were established as harmonised “sibling” cohorts to develop a mechanistically informed framework for stratifying psychiatric disorders. Here, we describe the study design, methodology, and cohort characteristics.
Self‐harm in individuals with substance use disorders: Predictive factors and risk model
INTRODUCTION Substance use disorders (SUDs) are associated with more than a 10-fold increased risk of self-harm compared with general population samples [1] and represent a significant and potentially preventable cause of morbidity.
Characterising a stress-sensitive default mode network (DMN) deficit in major psychiatric disorders - Communications Biology
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Abstract Childhood trauma (CT) is associated with cognitive impairment across major psychiatric disorders. We tested a novel transdiagnostic hypothesis that atypical connectivity of the default mode network (DMN) mediates the association between childhood trauma (CT) and cognitive impairment. The sample of 1851 individuals aged 18-25 included 433 patients with depression, eating disorders, alcohol use disorder, psychosis and ADHD) and were recruited as part of the ESTRA/STRATIFY/IMAGEN studies.
By Sinead King, Zuo Zhang, Lauren Robinson, Robert Whelan, Frauke Nees, Marina Bobou, Tobias Banaschewski, Gareth Barker, Arun Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Luise Poustka, Sarah Hohmann, Nathalie E. Holz, Christian Baeuchl, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Jeanne M Winterer, Betteke van Noort, Argyris Stringaris, Yuning Zhang, Julia Sinclair, Gunter Schumann, Ulrike Schmidt, Sylvane Desrivières, David Cotter, Allan Young, Gary Donohoe, Eric Wolsztynski, M. John Broulidakis
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Nature
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Impact of intrawork rest breaks on doctors’ performance and well-being: systematic review
Discussion The breadth of break-related topics shows that efforts are being made to investigate break effectiveness in doctors. Overall, the existing literature suggests a positive effect of break taking on a range of well-being and performance outcomes.
Concurrent validity of an estimator of weekly alcohol consumption (EWAC) based on the extended AUDIT
Abstract Background and Aims The three-question Alcohol Use Disorders Identification Test (AUDIT-C) is frequently used in healthcare for screening and brief advice about levels of alcohol consumption. AUDIT-C scores (0–12) provide feedback as categories of risk rather than estimates of actual alcohol intake, an important metric for behaviour change.
SABAA project and the overlap between autism and addiction: Julia Sinclair talks to the SSA
“Behavioural addictions are still relatively new in terms of their definitions as disorders…at the moment, very little is known about where that overlaps about some of the behavioural traits of autistic people” SABAA is an SSA funded project looking at the overlap between autism and addiction. The project aims to identify research gaps and priorities as well as to provide guidance for future work. The SSA caught up with Professor Julia Sinclair to find out more.
Acute management of alcohol and other drug problems
Abstract Intoxication and withdrawal syndromes are common presentations in acute medicine. Good management is based on a comprehensive history, including a collateral one, and thorough examination looking for patterns of signs and symptoms, backed up by appropriate investigations.
Covid-19 is an addiction crisis| MHT
Julia Sinclair 03 November 2020 Sadly, I wasn’t shocked by the recent news that thousands of people in England died as a result of their drug use last year. All of my colleagues working on the frontline of addiction psychiatry regularly see people whose lives have been destroyed by their addiction, and many die young. Yet there is a misnomer that addicts bring it on themselves, that somehow with a little more willpower and determination they could quit their addiction if they really wanted to.
The fact that I am an alcoholic
Julia Sinclair 15 August 2019 Professor Julia Sinclair, chair of the Royal College of Psychiatrists’ addictions faculty, responds to soaring drug related deaths. George was a young graduate with longstanding anxiety and depression, who became addicted to heroin. He successfully engaged with treatment to tackle his addiction and became drug free. But when he tried to get help for his mental illness, he was turned away from services.
The acceptability of addressing alcohol consumption as a modifiable risk factor for breast cancer: a mixed method study within breast screening services and symptomatic breast clinics
The acceptability of addressing alcohol consumption as a modifiable risk factor for breast cancer: a mixed method study within breast screening services and symptomatic breast clinics Julia Sinclair1, Mark McCann2, Ellena Sheldon3, Isabel Gordon4, Lyn Brierley-Jones5, Ellen Copson6 1 Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK 2 MRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK 3 Core...
Baclofen for the treatment of alcohol use disorder: the Cagliari Statement
Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Basic Research and National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Bethesda, MD, USA Medication Development Program, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA Center for Alcohol and Addiction Studies, Department of...
Baclofen and alcohol in France - Authors' reply
Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Basic Research and National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Bethesda, MD, USA Medication Development Program, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA Center for Alcohol and Addiction Studies, Department of...
Does prescribing psychiatric medication really make it less likely that alcohol is involved in a self-poisoning?
You have accessRestricted access Does prescribing psychiatric medication really make it less likely that alcohol is involved in a self-poisoning? Jonathan Chick, Colin Drummond, Julia Sinclair The British Journal of Psychiatry Jul 2017, 211 (1) 52-53; DOI: 10.1192/bjp.211.1.52a
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