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Articles by Junchen Chen
Predicting comorbidities in psoriasis using TCM constitution and multimodal data: a prospective cohort study protocol
Abstract Background: Psoriasis is a chronic inflammatory skin disease associated with multiple systemic comorbidities. Patients exhibit considerable individual variability in response to systemic therapies, making treatment outcomes and adverse reactions difficult to predict. Traditional Chinese Medicine (TCM) constitution theory may explain this variability, but prospective validation is lacking.
Manganese-Chelated Liposomes Encapsulating Antiepileptic Drugs molecules for Epilepsy Treatment
Manganese-Chelated Liposomes Encapsulating Antiepileptic Drugs molecules for Epilepsy Treatment Epilepsy is characterized by unpredictable and recurrent seizures, necessitating long-term prophylactic medication to maintain high drug concentrations at the site of onset. However, this approach, coupled with the blood-brain barrier (BBB)'s impediment, often leads to significant toxicity and drug resistance.
Evaluating Triptan Safety in Pediatric Migraine Management: A Comprehe
Introduction Migraine is a widespread issue that poses a significant burden on people across various age ranges and populations.1 In childhood, migraine is the most frequent primary headache, with its prevalence increasing with age and mainly changing in connection with puberty, occurring between 8–14 years for girls and 9–15 years for boys.2,3 Triptans are considered the standard of care for acute migraine treatment, with 5-Hydroxytryptamine 1 (5-HT1) receptor agonists remaining a mainstream...
Genome-Wide Identification of the GbUBC Gene Family in Sea-Island Cotton (Gossypium barbadense) and the Active Regulation of Drought Resistance in Cotton by GbUBC23
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Genome-Wide Mapping of RNA-Protein Associations via Sequencing
Abstract RNA-protein interactions are crucial for regulating gene expression and cellular functions, with their dysregulation potentially impacting disease progression. Systematically mapping these interactions is resource-intensive due to the vast number of potential RNA and protein interactions.
Establishment of a model to predict mortality after decompression craniotomy for traumatic brain injury
1 INTRODUCTION Traumatic brain injury (TBI) is a devastating neurological disorder that is the most common cause of traumatic death worldwide (Fleminger & Ponsford, 2005; Zink, 2001). Craniocerebral injury can disturb the normal intracranial physiology (cerebrospinal fluid circulation, blood circulation, and cell metabolism), resulting in malignant intracranial pressure (ICP) as the main cause of death (Stocchetti & Maas, 2014).
RYBP modulates embryonic neurogenesis involving the Notch signaling pathway in a PRC1-independent pattern
Highlights • Rybp deficiency inhibits the proliferation and promotes the neuronal differentiation of embryonic neural progenitor cells (eNPCs) • Rybp deficiency impairs the morphological development of hippocampal neuron • Rybp loss does not affect the global level of ubiquitination of H2A in eNPCs, but promotes CIR1 competing with RBPJ to bind with NICD • The inhibited Notch signaling in Rybp-deficient eNPCs can be rescued by ectopic Hes5 Summary RYBP (Ring1 and YY1 binding protein), an...
Ogt controls neural stem/progenitor cell pool and adult neurogenesis through modulating Notch signaling
Highlights • Ogt deficiency impairs the aNSPC pool and induces aberrant neurogenesis • Ogt deficiency in aNSPCs leads to impaired cognitive function in mice • Ogt regulates Notch signaling mainly through modulating TM/ICD • Ogt deficiency in aNSPCs promotes Itch binding to TM/ICD Summary Ogt catalyzed O-linked N-acetylglucosamine (O-GlcNAcylation, O-GlcNAc) plays an important function in diverse biological processes and diseases.
O-GlcNAcylation regulates the methionine cycle to promote pluripotency of stem cells
The health span of supercentenarians might be partly explained by the expansion of T cells that kill infected or abnormal cells.
The Detection of 5-Hydroxymethylcytosine in Neural Stem Cells and Brains of Mice
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Thymic stromal lymphopoietin epigenetically upregulates Fc receptor γ subunit-related receptors on antigen-presenting cells and induces TH2/TH17 polarization through dectin-2 - Journal of Allergy and Clinical Immunology
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Fig 1 TSLP upregulates expression of FcRγ and FcRγ-related receptors on human monocytes. Normal human CD14+ monocytes were treated with or without TSLP for 3 days.
Nuclear envelope-distributed CD147 interacts with and inhibits the transcriptional function of RING1 and promotes melanoma cell motility
Melanoma accounts for nearly 80% of all deaths associated with skin cancer.CD147 plays a very important role in melanoma progression and the expression level may correlate with tumor malignancy. RING1 can bind DNA and act as a transcriptional repressor, play an important role in the aggressive phenotype in melanoma. The interactions between CD147 and RING1 were identified with a yeast two-hybrid and RING1 interacted with CD147 through the transmembrane domain.
Metal organic framework-derived CoZn alloy /N-doped porous carbon nanocomposites: tunable surface area and electromagnetic wave absorption properties
N-doped porous carbon with uniformly dispersed CoZn alloy nanoparticles is synthesized through pyrolysis of bimetallic zeolitic imidazolate framework containing Zn and Co elements. The surface area, pore size distribution and graphitization of the composites can be modulated easily by changing the molar ratio of Zn and Co of the zeolitic imidazolate framework. With the increasing content of Zn, the graphitization drops gradually and the surface area value first increases and then reduces.
Metal organic framework-derived CoZn alloy/N-doped porous carbon nanocomposites: tunable surface area and electromagnetic wave absorption properties
N-Doped porous carbon with uniformly dispersed CoZn alloy nanoparticles has been synthesized through the pyrolysis of a bimetallic zeolitic imidazolate framework containing Zn and Co elements. The surface area, pore size distribution and graphitization of the composites can be modulated easily through changing the molar ratio of Zn to Co in the zeolitic imidazolate framework.
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