Junfeng Chen
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Articles by Junfeng Chen
MgO Distribution Evolution and Triple Synergistic Hydration-Resistance Mechanism in CaO–MgO–CaZrO 3 Refractories
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. References 1, , , et al., “Comparative Study on Interaction Between Rare Earth Oxide Refractories and Rare Earth Treated Steel,” International Journal of Minerals, Metallurgy and Materials 30, no. 11 (2023): 1496–1505.
High-temperature superconductivity at 100K in La 3− x Nd x Ni 2 O 7
Abstract Systematically controlling the superconducting transition temperature (Tc) in the bilayer Ruddlesden-Popper nickelate La3Ni2O7 remains a significant challenge. Here, we address this by synthesizing high-quality polycrystalline La3−xNdxNi2O7 (0 ≤ x ≤ 2.4) with record-level rare-earth substitution. Nd doping compresses the lattice and enhances the spin density wave (SDW) transition temperature, and elevates the pressure required for the orthorhombic-to-tetragonal structural transition.
Nonlinear Sciences > Chaotic Dynamics
[Submitted on 9 Jul 2026 (v1), last revised 14 Oct 2026 (this version, v2)] View PDF HTML (experimental) Subjects: Chaotic Dynamics (nlin.CD); Data Analysis, Statistics and Probability (physics.data-an) Cite as: arXiv:2607.08323 [nlin.CD] (or arXiv:2607.08323v2 [nlin.CD] for this version) https://doi.org/10.48550/arXiv.2607.08323
Low-intensity pulsed ultrasound promotes peripheral nerve regeneration by alleviating Schwann cells pyroptosis
Abstract Peripheral nerve injury (PNI), a common clinical condition, heavily relies on the functional condition of Schwann cells (SCs) for effective repair. Emerging evidence shows that excessive pyroptosis of SCs hinders neural regeneration. Low-intensity pulsed ultrasound (LIPUS), a non-invasive physical therapy, shows potential in tissue repair; however, its role in regulating SCs pyroptosis remains unclear.
snRNA sequencing-based skeletal muscle analysis of Jiangquan black pigs with different average daily growth rates
Abstract The Jiangquan black pigs, a new breed of swine obtained by introducing traits from Duroc pigs into Yimeng black pigs, exhibits fast growth rates and high meat quality. To understand how daily weight gain influences muscle development in this breed, we analyzed longissimus dorsi muscle cell subpopulations from Jiangquan black pigs using snRNA and bulk RNA sequencing.
Long-term sucralose exposure accelerates ovarian aging via gut microbiota dysbiosis
Abstract The increasing prevalence of obesity, diabetes, and other metabolic disorders is driving the application of sucralose in the food industry. However, its direct effects on the reproductive function have not been sufficiently investigated. Chronic sucralose consumption may induce ovarian aging, leading to ovarian dysfunction. This occurs in association with intestinal dysbiosis and disruption of intestinal tight junctions caused by prolonged intake of sucralose.
Shaking and withering intensity from oolong tea processing alters the chemical and sensory quality of tobacco - Scientific Reports
Abstract Tobacco curing is decisive for final leaf quality, but conventional methods rely mainly on temperature and humidity regulation, resulting in flavor profiles that are overly dependent on raw leaf material and offer limited plasticity. To actively design aroma characteristics, this study introduces the shaking-withering principle from oolong tea processing, applying controlled mechanical and oxidative stress to steer the aroma-chemical transformation of tobacco leaves.
Mechanistic drivers of PD-L1/CTLA-4 checkpoint inhibitor–associated immune toxicity and systemic organ injury
Abstract Background: Immune checkpoint inhibitors targeting PD-1/PD-L1 and CTLA-4 have substantially improved outcomes in multiple malignancies, but they may also trigger dysregulated immune activation accompanied by systemic toxic effects and multi-organ injury.
ATAD2 drives immunotherapy resistance by promoting lactic acid-mediated CD8 + T cell dysfunction in lung adenocarcinoma
Abstract Background: T cell-based immunotherapies have improved outcomes in lung adenocarcinoma (LUAD), yet many patients develop primary or acquired resistance. Tumor-intrinsic mechanisms that suppress CD8+ T cell function remain incompletely understood. Methods: Public LUAD transcriptomic datasets were analyzed to assess the association of ATPase family AAA domain-containing protein 2 (ATAD2) with prognosis and immune infiltration.
Non-human primate seasonal transcriptome atlas reveals seasonal changes in physiology and diseases - Nature Communications
Abstract The metabolic, immune, and endocrine systems show profound seasonal changes in animals, including humans. In addition, morbidity from cardiovascular and psychiatric diseases is more severe and mortality rate is higher in winter. However, their molecular mechanisms remain unknown. Here we report the seasonal transcriptome of 80 tissues collected over 1 year from male and female rhesus macaques kept in a semi-natural outdoor environment.
A Comparative Metabolomics Study of the Potential Marker Compounds in Feces from Different Hybrid Offspring of Huainan Pigs
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Double Decomposition and Fuzzy Cognitive Graph-Based Prediction of Non-Stationary Time Series
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
STR mutations on chromosome 15q cause thyrotropin resistance by activating a primate-specific enhancer of MIR7-2/MIR1179 - Nature Genetics
Abstract Thyrotropin (TSH) is the master regulator of thyroid gland growth and function. Resistance to TSH (RTSH) describes conditions with reduced sensitivity to TSH. Dominantly inherited RTSH has been linked to a locus on chromosome 15q, but its genetic basis has remained elusive. Here we show that non-coding mutations in a (TTTG)4 short tandem repeat (STR) underlie dominantly inherited RTSH in all 82 affected participants from 12 unrelated families.
Exploring optimal straw mulch thickness during freeze-thaw periods in the central Yellow River basin: Field observations and numerical modelling
CONFLICT OF INTEREST STATEMENT The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. REFERENCES , , & (2016) Characteristics of soil freeze–thaw cycles and their effects on water enrichment in the rhizosphere. Geoderma, 264, 132–139.
Quantitative Detection of Pipeline Cracks Based on Ultrasonic Guided Waves and Convolutional Neural Network
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
High-Throughput Synthesis, Purification, and Application of Alkyne-Functionalized Discrete Oligomers
The convergence of organic synthesis and polymer chemistry has enabled the design and study of oligomers and polymers with unprecedented levels of control over the molecular structure. By bringing the molecular precision associated with small molecules to macromolecular systems, strategies for the scalable preparation of discrete, multifunctional oligomers allow key structural parameters such as the number/arrangement of functional units and molar mass/degree of polymerization to be addressed.
High-Throughput Synthesis, Purification, and Application of Alkyne-Functionalized Discrete Oligomers
The convergence of organic synthesis and polymer chemistry has enabled the design and study of oligomers and polymers with unprecedented levels of control over the molecular structure. By bringing the molecular precision associated with small molecules to macromolecular systems, strategies for the scalable preparation of discrete, multifunctional oligomers allow key structural parameters such as the number/arrangement of functional units and molar mass/degree of polymerization to be addressed.
Diversity | Free Full-Text | Understanding and Mitigating the Purchase Intention of Medicines Containing Saiga Antelope Horn among Chinese Residents: An Analysis of Influencing Factors
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
High-performance ternary NiFeCo-LDH nanosheets for supercapacitors by cation modulation and sodium dodecyl sulfonate intercalation
High-performance ternary NiFeCo-LDH nanosheets for supercapacitors by cation modulation and sodium dodecyl sulfonate intercalation Layered double hydroxides (LDHs) hold significant promise for supercapacitors owing to their superior redox properties and customizable structure. Nevertheless, LDHs exhibit an experimental specific capacity lower than the theoretical value due to their undesirable electronic structure and limited electrical conductivity resulting from narrow interlayer spacing.
Functional divergence of CYP76AKs shapes the chemodiversity of abietane-type diterpenoids in genus Salvia - Nature Communications
Abstract The genus Salvia L. (Lamiaceae) comprises myriad distinct medicinal herbs, with terpenoids as one of their major active chemical groups. Abietane-type diterpenoids (ATDs), such as tanshinones and carnosic acids, are specific to Salvia and exhibit taxonomic chemical diversity among lineages.
Braided Liquid Crystal Elastomer Fiber Actuator with Programmable Deformation for Artificial Muscles
Abstract Liquid crystal elastomer fibers (LCEFs) are promising materials for constructing artificial muscles. However, the practical applications in smart wearable textiles and soft robots are still hindered due to their weak tensile performance and complex actuation integration. In this work, an LCEFs braided actuator is fabricated in which several LCEFs are integrated with silver-plated nylon strands using the textile braiding method.
Effect of Soil Texture on Water and Salt Transport in Freeze-Thaw Soil in the Shallow Groundwater Area
Abstract : Research on the variation in soil water, heat, and salt in unsaturated zones during the freeze–thaw process has great significance in efficiently utilizing water resources and preventing soil salinization. The freeze–thaw field experiment was carried out with the lysimeter as the test equipment to analyze characteristics of the soil freeze–thaw process, profile water content, main ion content, and salt content of three textured soils with the groundwater table depth of 0.5 m.
Log odds of positive lymph nodes as a novel prognostic predictor for gastric cancer: a systematic review and meta-analysis - BMC Cancer
Data sources We searched PubMed, Medline, Embase, Web of Science and the Cochrane Library for relevant studies from inception to March 7, 2022, which formed the basis for evidence used to conduct the meta-analysis. The following keywords were used: “log odds of positive lymph nodes”, “LODDS”, and “gastric cancer”.
[2305.12860] Combinatorial-hybrid Optimization for Multi-agent Systems under Collaborative Tasks
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The Impacts of the Asian Elephants Damage on Farmer’s Livelihood Strategies in Pu’er and Xishuangbanna in China
Abstract : The human–elephant conflict is a current issue that receives global attention and occurs in all elephant-distribution countries. This paper focuses on Pu′er and Xishuangbanna cities in the distribution area of Asian elephants in Yunnan Province. Based on two case studies, we collect basic information from local farmers regarding the severity of the damage caused by Asian elephants and the impact this has on their psychology.
LiDAR-assisted accuracy improvement strategy for binocular visual measurement
Abstract The measurement model of binocular vision is inaccurate when the measurement distance is much different from the calibration distance, which affects its practicality. To tackle this challenge, we proposed what we believe to be a novel LiDAR-assisted accuracy improvement strategy for binocular visual measurement. First, the 3D points cloud and 2D images were aligned by the Perspective-n-Point (PNP) algorithm to realize calibration between LiDAR and binocular camera.
Prostaglandin E2 synchronizes lunar-regulated beach spawning in grass puffers
Andreatta G. Tessmar-Raible K. The still dark side of the moon: molecular mechanisms of lunar-controlled rhythms and clocks. J. Mol. Biol. 2020; 432: 3525-3546 Circalunar clocks-old experiments for a new era. BioEssays. 2021; 43: e2100074 Levy O. Appelbaum L. Leggat W. Gothlif Y. Hayward D.C. Miller D.J. Hoegh-Guldberg O. Light-responsive cryptochromes from a simple multicellular animal, the coral Acropora Millepora. Science. 2007; 318: 467-470 Zurl M. Poehn B. Rieger D. Krishnan S. Rokvic D.
Computational Workflow to Study the Diversity of Secondary Metabolites in Fourteen Different Isatis Species
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited.
Enzyme-like catalysis by single chain nanoparticles that use transition metal cofactors
Enzyme-like catalysis by single chain nanoparticles that use transition metal cofactors† Thao M. Xiong,a Edzna S. Garcia,a Junfeng Chen,a Lingyang Zhu, b Ariale J. Alzonaa and Steven C.
A novel scintillation screen for achieving high-energy ray detection with fast and full-color emission
A novel scintillation screen for achieving high-energy ray detection with fast and full-color emission Traditional inorganic scintillation crystals have a high stopping power to high-energy particles or rays, however, their wide applications are limited due to the fixed emission band. CsPbX3 (X = Cl, Br, I) perovskite nanocrystals (CsPbX3 NCs) have been proved to achieve full-color emission and effective X-ray detection, while failed to detect γ-ray effectively due to its weak absorption ability.
Reconstruction of the birth of a male sex chromosome present in Atlantic herring
Research Article Nima Rafati, Junfeng Chen, Amaury Herpin, Mats E. Pettersson, Fan Han, Chungang Feng, Ola Wallerman, Carl-Johan Rubin, Sandrine Péron, Arianna Cocco, Mårten Larsson, Christian Trötschel, View ORCID ProfileAnsgar Poetsch, Kai Korsching, Wolfgang Bönigk, Heinz G. Körschen, View ORCID ProfileFlorian Berg, View ORCID ProfileArild Folkvord, View ORCID ProfileU. Benjamin Kaupp, View ORCID ProfileManfred Schartl, and View ORCID ProfileLeif Andersson
A Bioorthogonal Small Molecule Selective Polymeric “Clickase”
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2020, XXXX, XXX RETURN TO ARTICLES ASAPPREVArticleNEXT Junfeng Chen, Ke Li, Sarah E. Bonson, and Steven C. Zimmerman* LEARN ABOUT THESE METRICS Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.
Single-Chain Nanoparticle Delivers a Partner Enzyme for Concurrent and Tandem Catalysis in Cells
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2020, XXXX, XXX RETURN TO ARTICLES ASAPPREVCommunicationNEXT Junfeng Chen Ke Li Ke Li Department of Chemistry, University of Illinois, Urbana, Illinois 61801, United States Ji Seon “Lucy” Shon Ji Seon “Lucy” Shon Department of Chemistry, University of Illinois, Urbana, Illinois 61801, United States Steven C. Zimmerman* Steven C.
Single-Chain Nanoparticle Delivers a Partner Enzyme for Concurrent and Tandem Catalysis in Cells
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2020, 142, 10 RETURN TO ISSUEPREVCommunicationNEXT Junfeng Chen Ke Li Ke Li Department of Chemistry, University of Illinois, Urbana, Illinois 61801, United States Ji Seon “Lucy” Shon Ji Seon “Lucy” Shon Department of Chemistry, University of Illinois, Urbana, Illinois 61801, United States Steven C. Zimmerman* Steven C.
Identification and degradation characteristics of Bacillus cereus strain WD-2 isolated from prochloraz-manganese-contaminated soils
Loading metrics Open Access Peer-reviewed Research Article Jie Jiang , Meizhen Tang , Junfeng Chen , Yuewei Yang Jie Jiang, Meizhen Tang, Junfeng Chen, Yuewei Yang Published: August 9, 2019 https://doi.org/10.1371/journal.pone.0220975 Figures Abstract The bacterial strain WD-2, which was capable of efficiently degrading prochloraz-manganese, was isolated from soil contaminated with prochloraz-manganese, selected through enrichment culturing and identified as Bacillus cereus.
Polymeric “Clickase” Accelerates the Copper Click Reaction of Small Molecules, Proteins, and Cells
Recent work has shown that polymeric catalysts can mimic some of the remarkable features of metalloenzymes by binding substrates in proximity to a bound metal center. We report here an unexpected role for the polymer: multivalent, reversible, and adaptive binding to protein surfaces allowing for accelerated catalytic modification of proteins.
Enzyme-like Click Catalysis by a Copper-Containing Single-Chain Nanoparticle
A major challenge in performing reactions in biological systems is the requirement for low substrate concentrations, often in the micromolar range. We report that copper cross-linked single-chain nanoparticles (SCNPs) are able to significantly increase the efficiency of copper(I)-catalyzed alkyne–azide cycloaddition (CuAAC) reactions at low substrate concentration in aqueous buffer by promoting substrate binding.
Designed transition metal catalysts for intracellular organic synthesis
The development of synthetic, metal-based catalysts to perform intracellular bioorthogonal reactions represents a relatively new and important area of research that combines transition metal catalysis and chemical biology. The ability to perform reactions in cellulo, especially those transformations without a natural counterpart, offers a versatile tool for medicinal chemists and chemical biologists.
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