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Articles by Junnan Wu
Metabolic reprogramming modulates cardiomyocyte hypertrophy via GLS1 in chronic kidney disease in male mice
Abstract Left ventricular hypertrophy (LVH) is a major cardiovascular complication of chronic kidney disease (CKD), yet its mechanisms remain poorly understood. Here we show that in preclinical experiments, CKD drives cardiomyocyte metabolic reprogramming characterized by enhanced glutaminolysis and impaired oxidative phosphorylation in male C57BL/6J mice.
Cross-elbow stent placement for refractory arteriovenous fistula stenosis and chronic total occlusion in hemodialysis patients: a single-center retrospective cohort of 42 cases
Abstract Cross-elbow stent placement in hemodialysis arteriovenous fistulas (AVFs) has been avoided due to risks of fracture, kinking, deformation, migration, and infection. However, elbow lesions may be refractory to angioplasty and progress to chronic total occlusion (CTO). We evaluated the safety, feasibility, and patency of cross-elbow stenting for AVF salvage.
Single-cell and high-resolution spatial profiling of podocytopathies reveals core mechanisms of podocyte injury
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Podocytes (PODs) play a critical role in maintaining glomerular filtration function, and their injury is a key driver of progressive podocytopathies (PCPs). Despite their clinical importance, the molecular and spatial mechanisms underlying POD injury remain poorly understood.
Mix proportion optimization of red mud manufactured sand foam concrete and its sulfate resistance
Abstract This study optimized the mix proportion of red mud manufactured sand foam concrete (RMMSFC) using orthogonal tests and evaluated its sulfate resistance. Results showed that the sand-cement ratio most significantly influenced dry density and porosity, while foam content predominantly governed strength.
Thymopentin enhances adenoviral oncolytic therapy by regulating macrophages and CD8 + T cells
Abstract Oncolytic viruses are cancer therapies that selectively replicate in tumors, deliver therapeutic genes, and stimulate immune responses. Combining these viruses with immune-boosting agents could enhance their effectiveness. Thymopentin (TP5), an immune-modulating peptide, may enhance the antitumour efficacy of ADV. We tested TP5 combined with adenovirus type 5 in tumor models, measuring tumor growth and immune changes using flow cytometry and antibody-based cell depletion.
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis
Editor’s summary Single-nucleotide polymorphisms within a locus on chromosome 15 are associated with kidney function in humans. There are several genes within that locus, including glutathione-specific gamma–glutamylcyclotransferase 1 (CHAC1), which degrades the antioxidant glutathione. Here, Kolligundla and colleagues finely mapped the locus on chromosome 15 and highlighted CHAC1 as a likely kidney disease risk gene.
Agronomy | Free Full-Text | Evaluation of Soil Suppressiveness of Various Japanese Soils against the Soybean Cyst Nematode Heterodera glycines and Its Relation with the Soil Chemical and Biological Properties
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Insight into melting point differences of dinitroimidazoles and dinitropyrazoles from the view of intermolecular interactions
Insight into melting point differences of dinitroimidazoles and dinitropyrazoles from the view of intermolecular interactions Dinitroimidazole (DNI) and dinitropyrazole (DNP), along with their congeners, possess similar molecular structures but exhibit distinct melting points.
Single-cell transcriptomics and chromatin accessibility profiling elucidate the kidney protective mechanism of mineralocorticoid receptor antagonists
ResearchGeneticsNephrology Open Access | 10.1172/JCI157165 J Clin Invest. https://doi.org/10.1172/JCI157165. Copyright © 2023, Abedini et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Supplemental material Version history Version 1 (October 31, 2023): In-Press Preview
The Effects of Localized Plant-Soil-Microbe Interactions on Soil Nitrogen Cycle in Maize Rhizosphere Soil under Long-Term Fertilizers
1. Introduction The nitrogen (N) cycle is the most basic ecological process in agricultural ecosystems. Soil N balance is very important for maintaining soil quality and crop growth and is directly related to the stability and productivity of agricultural ecosystems [1,2].
Research on Safety Evaluation of Municipal Sewage Treatment Plant Based on Improved Best-Worst Method and Fuzzy Comprehensive Method
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APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis
(A) Genome browser view of read density in single-nucleus analysis of accessible chromatin (snATAC)-seq clusters in human kidney cells at APOL1 locus. Endo, endothelial cells. (B) Representative images of CD31 (blue) and APOL1 (red) in situ hybridization in a healthy human lung sample. Black arrows indicate co-localizations of APOL1 with CD31. Scale bar, 20 μm. (C) Representative images of double immunofluorescence staining of a healthy human lung sample with CD31 (red) and APOL1 (green).
Rod-shaped Cu1.81Te as a novel cathode material for aluminum-ion batteries
Rod-shaped Cu1.81Te as a novel cathode material for aluminum-ion batteries† Aluminum-ion batteries (AIBs) are supposed to be one of the energy storage systems with great potentialities on account of their high safety, low cost and high theoretical volumetric capacity. Herein, we report a novel rod-shaped Cu1.81Te cathode material for AIBs. At 40 mA g−1, the initial discharge capacity can reach 144 mA h g−1.
Rod-shaped Cu1.81Te as a Novel Cathode Material for Aluminum Ion Batteries
Rod-shaped Cu1.81Te as a Novel Cathode Material for Aluminum Ion Batteries Junnan Wu, Dongzheng Wu, Min Zhao, Zhipeng Wen, Jiali Jiang, Jing Zeng and Jinbao Zhao Abstract Aluminum-ion batteries (AIBs) are supposed to be one of energy storage systems with great potentialities on account of their high safety, low cost and high theoretical volumetric capacity.
Angiotensin II induces calcium/calcineurin signaling and podocyte injury by downregulating microRNA-30 family members
28.Kinoshita Y, Kondo S, Urushihara M, Suga K, Matsuura S, Takamatsu M, Shimizu M, Nishiyama A, Kawachi H, Kagami S (2011) Angiotensin II type I receptor blockade suppresses glomerular renin-angiotensin system activation, oxidative stress, and progressive glomerular injury in rat anti-glomerular basement membrane glomerulonephritis. Transl Res 158:235–248CrossRefPubMedGoogle Scholar
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