Karrnan Pathmanandavel

CONFLICT OF INTEREST STATEMENT No conflicts to disclose. REFERENCES 1, , . Human peripheral blood B lymphocyte subpopulations: functional and phenotypic analysis of surface IgD positive and negative subsets. J Immunol. 1986; 136(1): 83-92. 2, , . T cell-dependent activation of B cell proliferation and differentiation by immobilized monoclonal antibodies to CD3. J Immunol. 1988; 140(11): 3736-3744. 3, , , et al.

Abstract Aim Coeliac disease (CD) can remain undiagnosed due to absent/atypical symptoms. We evaluated screening for CD in undifferentiated paediatric patients in the emergency department (ED). Methods Subjects were all patients presenting to a children's hospital ED during the study period who had blood taken. Plasma remaining after routine care was tested for tissue transglutaminase IgA (tTG IgA) and deamidated gliadin IgG (DGP IgG) antibodies.

Under a Creative Commons license open access Highlights • Osteoclasts fission into daughter cells called osteomorphs • Osteomorphs fuse and recycle back into osteoclasts • Osteomorph upregulated genes control bone structure and function in mice • Osteomorph upregulated genes are implicated in rare and common bone diseases in humans Summary Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/macrophage-derived precursors that are thought to undergo...