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Pei Ying Ng

As seen in: Cell Press
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Articles

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

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By Niall Byrne, Michelle M. McDonald, Weng Hua Khoo, Pei Ying Ng
| Cell Press Verified
(Cell 184, 1330–1347.e1–e13; March 4, 2021) As a result of an author oversight in the originally published version of this article, the name of an author, Alexander Corr, did not appear in the author list. This error has now been corrected in the article online, and the author contributions have been updated accordingly to reflect Alexander Corr’s contributions to the scRNA-seq analysis. Article Info Identification DOI: https://doi.org/10.1016/j.cell.2021.03.010 Copyright © 2021 The Author(s).
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Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

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By Michelle M. McDonald, Weng Hua Khoo, Ya Xiao, Abigail K. Grootveld, Imogen Moran, Danyal Butt, Akira Nguyen, Sean Warren, Maté Biro, Natalie C. Butterfield, Pei Ying Ng, Jad Zamerli, Peter Thatcher, Wunna Kyaw, Karrnan Pathmanandavel, Siobhan E. Guilfoyle
| ScienceDirect Verified
Under a Creative Commons license open access Highlights • Osteoclasts fission into daughter cells called osteomorphs • Osteomorphs fuse and recycle back into osteoclasts • Osteomorph upregulated genes control bone structure and function in mice • Osteomorph upregulated genes are implicated in rare and common bone diseases in humans Summary Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/macrophage-derived precursors that are thought to undergo...
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