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ArticleOnline nowOpen access Affiliations & Notes 1Laboratory of Tumor Microenvironment and Therapeutic Resistance, Department of Oncology, KU Leuven, Leuven, 3000, Belgium 2Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, 3000, Belgium 3VIB Center for Cancer Biology Research, Leuven, 3000, Belgium 4Department of Applied Computational Cancer Research, Institute for AI in Medicine (IKIM), University Hospital Essen, Essen, 45147, Germany...
Highlights • Thwarting LEC autophagy prevents lymphocyte egress from the lymph node (LN) • LEC autophagy governs the S1P gradient and the intranodal dynamics of T and NK cells • Loss of LEC autophagy remodels niche-specific LEC phenotypes in tumor-draining LNs • LEC-autophagy blockade blunts efficacy of ICBs by sequestering T and NK cells in the LNs Summary Lymphatic endothelial cells (LECs) of the lymph node (LN) parenchyma orchestrate leukocyte trafficking and peripheral T cell dynamics.
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