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Katjuša Koler on Muck Rack

Katjuša Koler

As seen in: Science Magazine, Cell Press
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Articles

SHLD2 loss is a synthetic vulnerability to Polθ inhibition combined with radiotherapy

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By Kevin Jaksch, Hoang Phan, Mukund Palat Rao, Gonzalo Rodriguez-Berriguete, Alessandro Cicconi, Nicole Machado, Célia Gotorbe, David Nderitu, Wei-Chen Cheng, Marie Boursier, Vera Grinkevich, Bethany Hill, Katjuša Koler, Sophie Langdon, Suraj Menon, Shaun Moore Verified, Joana B. Neves, Eeson Rajendra, Purusotha Thambiayah, Gerissa Fowler, Aurora Cerutti, Jayesh B. Majithiya, Natalie M. Palmer-Deverill, Marina Roy-Luzarraga, Asmita Thapa
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Inhibition of DNA polymerase theta (Polθ), an essential enzyme for repairing DNA double-strand breaks (DSBs) via microhomology-mediated end joining (MMEJ), has proven to be an exquisitely effective monotherapy in HR-deficient tumor models.
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Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s disease

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By Sang Su Kwak, Mehdi Jorfi, Djuna von Maydell, Zhiqing Liu, Younjung Choi, Joseph Park, Grisilda Bakiasi, Murat Cetinbas, Ana Griciuc, Luisa Quinti, Pourya Naderi Yeganeh, Katjuša Koler, Thejesh Kalatturu, Nelson Abarca
| Cell Press Verified
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Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s disease

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By Pourya Naderi Yeganeh, Sang Su Kwak, Mehdi Jorfi, Katjuša Koler, Thejesh Kalatturu, Djuna von Maydell, Zhiqing Liu, Younjung Choi, Joseph Park, Nelson Abarca, Grisilda Bakiasi, Murat Cetinbas, Ana Griciuc, Luisa Quinti, Weiming Xia, Rudolph E. Tanzi, Winston Hide, Doo Yeon Kim
| Cell Press Verified
Keywords Alzheimer’s disease drug target discovery tau pathology 3D human neuronal cell models transcriptomics phosphoproteomics integrative analysis pathway analysis p38 MAP kinase amyloid beta 42 Get full text access Log in, subscribe or purchase for full access. References 1. Blennow, K. ∙ de Leon, M.J. ∙ Zetterberg, H. Alzheimer’s disease Lancet. 2006; 368:387-403 2. Nelson, P.T. ∙ Braak, H.
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