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Nelson Abarca

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Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s disease

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By Sang Su Kwak, Mehdi Jorfi, Djuna von Maydell, Zhiqing Liu, Younjung Choi, Joseph Park, Grisilda Bakiasi, Murat Cetinbas, Ana Griciuc, Luisa Quinti, Pourya Naderi Yeganeh, Katjuša Koler, Thejesh Kalatturu, Nelson Abarca
| Cell Press Verified
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Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s disease

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By Pourya Naderi Yeganeh, Sang Su Kwak, Mehdi Jorfi, Katjuša Koler, Thejesh Kalatturu, Djuna von Maydell, Zhiqing Liu, Younjung Choi, Joseph Park, Nelson Abarca, Grisilda Bakiasi, Murat Cetinbas, Ana Griciuc, Luisa Quinti, Weiming Xia, Rudolph E. Tanzi, Winston Hide, Doo Yeon Kim
| Cell Press Verified
Keywords Alzheimer’s disease drug target discovery tau pathology 3D human neuronal cell models transcriptomics phosphoproteomics integrative analysis pathway analysis p38 MAP kinase amyloid beta 42 Get full text access Log in, subscribe or purchase for full access. References 1. Blennow, K. ∙ de Leon, M.J. ∙ Zetterberg, H. Alzheimer’s disease Lancet. 2006; 368:387-403 2. Nelson, P.T. ∙ Braak, H.
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