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Kazukuni Hayashi on Muck Rack

Kazukuni Hayashi

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Chemotherapy-induced activation of caspase-1 and IL-1α release by cancer cells remotely skews myelopoiesis to drive pro tumorigenic systemic neutrophil-dominant inflammation

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By Stephen Wong, Hongbo Gao, Haley Garcia, Sophie Porter, Mustafa Karabicici, Xen Ping Hoi, Crystal Shin, Lisa Bouchier-Hayes, Dimitrios Korentzelos, Chen Chen, Michael Brooks, Zheng Yin, Renil S. Titus, Lan Zhou, Yinan Gong, Yulin Li, Ziad M. El-Zaatari, Dharam Kaushik, Raj Satkunasivam, Fotis Nikolos, Keith Chan, Kazukuni Hayashi, Ethan J. Subel, Yung Hsing Huang, Mark D. Alonzo, Armine Kasabyan, Efrosini Tsouko
| Nature Verified
Abstract While chemotherapy-induced tumor cell death is known to modulate the local immune landscape, its systemic impact on distant bone marrow—a site essential for immune cell maturation—remains underexplored. Here, we show that gemcitabine chemotherapy induces inflammatory caspase-1-dependent pyroptosis in epithelial cancer cells (epiCaspase-1). Despite its inflammatory nature, epiCaspase-1-mediated cell death is non-immunogenic.
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