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Yinan Gong

As seen in: Nature, Frontiers, MDPI, BioRxiv
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Articles

Chemotherapy-induced activation of caspase-1 and IL-1α release by cancer cells remotely skews myelopoiesis to drive pro tumorigenic systemic neutrophil-dominant inflammation

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By Stephen Wong, Hongbo Gao, Haley Garcia, Sophie Porter, Mustafa Karabicici, Xen Ping Hoi, Crystal Shin, Lisa Bouchier-Hayes, Dimitrios Korentzelos, Chen Chen, Michael Brooks, Zheng Yin, Renil S. Titus, Lan Zhou, Yinan Gong, Yulin Li, Ziad M. El-Zaatari, Dharam Kaushik, Raj Satkunasivam, Fotis Nikolos, Keith Chan, Kazukuni Hayashi, Ethan J. Subel, Yung Hsing Huang, Mark D. Alonzo, Armine Kasabyan, Efrosini Tsouko
| Nature Verified
Abstract While chemotherapy-induced tumor cell death is known to modulate the local immune landscape, its systemic impact on distant bone marrow—a site essential for immune cell maturation—remains underexplored. Here, we show that gemcitabine chemotherapy induces inflammatory caspase-1-dependent pyroptosis in epithelial cancer cells (epiCaspase-1). Despite its inflammatory nature, epiCaspase-1-mediated cell death is non-immunogenic.
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BIM-Based Digital Construction Strategies to Evaluate Carbon Emissions in Green Prefabricated Buildings

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By HABIB ULLAH, Hong jing Zhang, Baolin Huang, Yinan Gong
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Mechanisms of alkaliptosis

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By Yinan Gong, Shamir Cassim, Chao-Yuan Chang
| Frontiers
Introduction Cell death is one group of mechanisms of the end of cell life and can occur quickly or gradually. Characteristic morphological changes, such as alterations in the nucleus, mitochondria and cell volume, often accompany cell death. The diversity of causes leads to differing degrees of morphological changes during the process of cell death (Ziegler and Groscurth, 2004).
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