Kellen Chen
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Articles by Kellen Chen
Fibroblasts of disparate developmental origins harbor anatomically variant scarring potential
Keywords scar wound healing fibrosis skin fibroblast single-cell RNA sequencing neural crest Get full text access Log in, subscribe or purchase for full access. References 1. Henderson, N.C. ∙ Rieder, F. ∙ Wynn, T.A. Fibrosis: from mechanisms to medicines Nature. 2020; 587:555-566 2. Li, D.J. ∙ Berry, C.E. ∙ Wan, D.C. ... Clinical, mechanistic, and therapeutic landscape of cutaneous fibrosis Sci. Transl. Med. 2024; 16, eadn7871 3. Brockes, J.P. ∙ Kumar, A.
Elevated Shear Stress Modulates Heterogenous Cellular Subpopulations to Induce Vascular Remodeling
Get full access to this article View all available purchase options and get full access to this article. References 1. Radwan MS, Barakat AZ, Jaber MM, et al. Free flap transfer with arteriovenous loop establishment for upper limb salvage in a crush injury. Plast Reconstr Surg Glob Open 2018;6(11):e1913; 2. Mambally SR, Santha KK. Utility of arteriovenous loops before free tissue transfer for post-traumatic leg defects. Indian J Plast Surg 2015;48(1):38–42; 3.
How preventing the body's immune response could make biomedical implants last longer
BIOMEDICAL IMPLANTS — SUCH as pacemakers, breast implants and orthopedic hardware like screws and plates to replace broken bones — have improved patient outcomes across a wide range of diseases. However, many implants fail because the body rejects them, and they need to be removed because they no longer function and can cause pain or discomfort.
Implants like pacemakers and insulin pumps often fail because of immune attacks − stopping them could make medical devices safer and longer-lasting
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Implants like pacemakers and insulin pumps often fail because of immune attacks − stopping them could make medical devices safer and longer-lasting
By Kellen Chen, Assistant Professor of Surgery, University of Arizona Biomedical implants - such as pacemakers, breast implants and orthopedic hardware like screws and plates to replace broken bones - have improved patient outcomes across a wide range of diseases. However, many implants fail because the body rejects them, and they need to be removed because they no longer function and can cause pain or discomfort.
Implants like pacemakers and insulin pumps often fail because of immune attacks − stopping them could make medical devices safer and longer-lasting Original
Biomedical implants – such as pacemakers, breast implants and orthopedic hardware like screws and plates to replace broken bones – have improved patient outcomes across a wide range of diseases. However, many implants fail because the body rejects them, and they need to be removed because they no longer function and can cause pain or discomfort.
Implants like pacemakers and insulin pumps often fail because of immune attacks − stopping them could make medical devices safer and longer-lasting
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.) kAmW%wt r~}'t#$p%x~}X q:@>65:42= :>A=2?ED – DF49 2D A246>2<6CD[ 3C62DE :>A=2?ED 2?5 @CE9@A65:4 92C5H2C6 =:<6 D4C6HD 2?5 A=2E6D E@ C6A=246 3C@<6? 3@?6D – 92G6 :>AC@G65 A2E:6?E @FE4@>6D 24C@DD 2 H:56 C2?86 @7 5:D62D6D] w@H6G6C[ k2 9C67lQ9EEADi^^5@:]@C8^`_]`__aTau3E>a]`_b__Qm>2?J :>A=2?ED 72:=k^2m 3642FD6 E96 3@5J C6;64ED E96>[ 2?5 E96J ?665 E@ 36 C6>@G65 3642FD6 E96J ?@ =@?86C 7F?4E:@?
Implants like pacemakers and insulin pumps often fail because of immune attacks − stopping them could make medical devices safer and longer-lasting
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.) kAmW%wt r~}'t#$p%x~}X q:@>65:42= :>A=2?ED – DF49 2D A246>2<6CD[ 3C62DE :>A=2?ED 2?5 @CE9@A65:4 92C5H2C6 =:<6 D4C6HD 2?5 A=2E6D E@ C6A=246 3C@<6? 3@?6D – 92G6 :>AC@G65 A2E:6?E @FE4@>6D 24C@DD 2 H:56 C2?86 @7 5:D62D6D] w@H6G6C[ k2 9C67lQ9EEADi^^5@:]@C8^`_]`__aTau3E>a]`_b__Qm>2?J :>A=2?ED 72:=k^2m 3642FD6 E96 3@5J C6;64ED E96>[ 2?5 E96J ?665 E@ 36 C6>@G65 3642FD6 E96J ?@ =@?86C 7F?4E:@?
Allometrically scaling tissue forces drive pathological foreign-body responses to implants via Rac2-activated myeloid cells - Nature Biomedical Engineering
Abstract Small animals do not replicate the severity of the human foreign-body response (FBR) to implants. Here we show that the FBR can be driven by forces generated at the implant surface that, owing to allometric scaling, increase exponentially with body size.
Implants like pacemakers and insulin pumps often fail because of immune attacks − stopping them could make medical devices safer and longer-lasting
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.) kAmW%wt r~}'t#$p%x~}X q:@>65:42= :>A=2?ED – DF49 2D A246>2<6CD[ 3C62DE :>A=2?ED 2?5 @CE9@A65:4 92C5H2C6 =:<6 D4C6HD 2?5 A=2E6D E@ C6A=246 3C@<6? 3@?6D – 92G6 :>AC@G65 A2E:6?E @FE4@>6D 24C@DD 2 H:56 C2?86 @7 5:D62D6D] w@H6G6C[ k2 9C67lQ9EEADi^^5@:]@C8^`_]`__aTau3E>a]`_b__Qm>2?J :>A=2?ED 72:=k^2m 3642FD6 E96 3@5J C6;64ED E96>[ 2?5 E96J ?665 E@ 36 C6>@G65 3642FD6 E96J ?@ =@?86C 7F?4E:@?
Implants like pacemakers and insulin pumps often fail because of immune attacks − stopping them could make medical devices safer and longer-lasting
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.) kAmW%wt r~}'t#$p%x~}X q:@>65:42= :>A=2?ED – DF49 2D A246>2<6CD[ 3C62DE :>A=2?ED 2?5 @CE9@A65:4 92C5H2C6 =:<6 D4C6HD 2?5 A=2E6D E@ C6A=246 3C@<6? 3@?6D – 92G6 :>AC@G65 A2E:6?E @FE4@>6D 24C@DD 2 H:56 C2?86 @7 5:D62D6D] w@H6G6C[ k2 9C67lQ9EEADi^^5@:]@C8^`_]`__aTau3E>a]`_b__Qm>2?J :>A=2?ED 72:=k^2m 3642FD6 E96 3@5J C6;64ED E96>[ 2?5 E96J ?665 E@ 36 C6>@G65 3642FD6 E96J ?@ =@?86C 7F?4E:@?
Cas9-mediated knockout of Ndrg2 enhances the regenerative potential of dendritic cells for wound healing - Nature Communications
Abstract Chronic wounds impose a significant healthcare burden to a broad patient population. Cell-based therapies, while having shown benefits for the treatment of chronic wounds, have not yet achieved widespread adoption into clinical practice. We developed a CRISPR/Cas9 approach to precisely edit murine dendritic cells to enhance their therapeutic potential for healing chronic wounds.
Skin grafts for burns injuries can lead to crippling scars - a drug that blocks the skin's ability to respond to physical stimuli could promote healing, new research in pigs finds
The Research Brief is a short take about interesting academic work. The big idea Reducing a skin graft’s responsiveness to its physical environment could help improve healing and reduce scarring from large injuries like burns or blast wounds, according to our recent study published in Science Translational Medicine. Historically, injuries that cover massive areas of the body like burns have high death rates.
Targeting circulating mechanoresponsive monocytes and macrophages to reduce fibrosis - Nature Biomedical Engineering
Abstract In response to injury, a variety of different cells are recruited to sites of injury to facilitate healing. Recent studies have examined the importance of the heterogeneity of tissue resident fibroblasts and mechanical signalling pathways in healing and fibrosis. However, tissue repair and the inflammatory response also involves blood cells that are recruited from the circulation. Here we identify mechanoresponsive myeloid subpopulations present in scar and unwounded skin.
Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing - Nature Biotechnology
Abstract ‘Smart’ bandages based on multimodal wearable devices could enable real-time physiological monitoring and active intervention to promote healing of chronic wounds. However, there has been limited development in incorporation of both sensors and stimulators for the current smart bandage technologies.
Skin grafts for burns injuries can lead to crippling scars - a drug that blocks the skin's ability to respond to physical stimuli could promote healing, new research in pigs finds | Regional | chronicle-tribune.com
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.) kAmW%wt r~}'t#$p%x~}X %96 k2 9C67lQ9EEADi^^E964@?G6CD2E:@?]4@>^FD^E@A:4D^C6D62C49\3C:67\gbab`Qm#6D62C49 qC:67k^2m :D 2 D9@CE E2<6 23@FE :?E6C6DE:?8 24256>:4 H@C<]k^Am kAmk6>m%96 3:8 :562k^6>mk^Am kAm#65F4:?8 2 D<:?
Skin grafts for burns injuries can lead to crippling scars
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.) (THE CONVERSATION) The Research Brief is a short take about interesting academic work. Reducing a skin graft's responsiveness to its physical environment could help improve healing and reduce scarring from large injuries like burns or blast wounds, according to our recent study published in Science Translational Medicine.
Disrupting mechanotransduction decreases fibrosis and contracture in split-thickness skin grafting
Information Published In Science Translational Medicine Volume 14 | Issue 645 May 2022 Copyright Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. This is an article distributed under the terms of the Science Journals Default License. Submission history Received: 17 June 2021 Accepted: 29 April 2022 Permissions Request permissions for this article. Acknowledgments We thank Y.
Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager
Maximizing the utility of miniproteins Abstract Supplementary Materials REFERENCES AND NOTES Maximizing the utility of miniproteins Miniproteins are an attractive option for targeted therapeutic development. Here, Crook et al. developed a CD3-targeting bispecific T cell engager with a PD-L1–binding cystine-dense miniprotein [also called a cystine-dense peptide (CDP)].
Emerging role for thymic stromal lymphopoietin-responsive regulatory T cells in colorectal cancer progression in humans and mice
Information Published In Science Translational Medicine Volume 14 | Issue 645 May 2022 Copyright Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. This is an article distributed under the terms of the Science Journals Default License. Submission history Received: 30 July 2021 Accepted: 25 April 2022 Permissions Request permissions for this article. Acknowledgments We thank A.
A rare case of Wohlfahrtiimonas chitiniclastica infection in California
Key words bacterial infection basal cell carcinoma general dermatology infection insects maggots microbiology oncology Wohlfahrtiimonas chitiniclastica wound healing wounds Introduction We report a case of Wohlfahrtiimonas chitiniclastica in the setting of neck, upper portion of the back, and right shoulder wounds with maggot infestation. W chitiniclastica is a gram-negative, aerobic, and nonmotile rod with strong chitinase activity. 1 Snyder S. Singh P. Goldman J.
Skin grafts for burns injuries can lead to crippling scars - a drug that blocks the skin's ability to respond to physical stimuli could promote healing, new research in pigs finds
The Research Brief[1] is a short take about interesting academic work. The big idea Reducing a skin graft’s responsiveness to its physical environment could help improve healing and reduce scarring from large injuries like burns or blast wounds, according to our recent study published in Science Translational Medicine[2]. Historically, injuries that cover massive areas of the body like burns have high death rates[3].
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