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Articles by Keyi Wang
Feasibility of propofol–lidocaine anesthesia with paracervical block under preserved spontaneous breathing for day-case hysteroscopy
Abstract Day-case hysteroscopy requires an anesthetic approach that provides adequate procedural conditions while facilitating recovery. In this prospective single-arm pilot study, 60 women undergoing elective day-case hysteroscopy received intravenous propofol–lidocaine anesthesia combined with paracervical block while spontaneous breathing was maintained.
Triggering SORL1 Expression Restricts ccRCC Progression by Inducing Ubiquitination-Mediated c-Myc Degradation
Filename Description cas70516-sup-0001-Supinfo.docxWord 2007 document , 10.1 MB Figure S1: Clinical features of SORL1 expression in 33 human cancers. (A) Expression of SORL1 in 33 types of human cancers. (B) Relationship between the expression of SORL1 and clinicopathological features in ccRCC. (C) CNV analysis for identifying Tumor/Epithelial cells. (D) The relationships between SORL1 expression and patients' survival of different human cancers.
ZBTB10 inhibits ccRCC progression by epigenetically silencing GPX4 through a self-regulatory ZBTB10/DNMT1/FBXW4 loop
Abstract Clear cell renal cell carcinoma (ccRCC) is a common urological malignancy with limited therapeutic options for advanced disease. Aberrant DNA methylation and dysregulated ferroptosis have both been implicated in ccRCC progression, yet the mechanisms connecting these processes remain incompletely defined. Here, we identify ZBTB10 as a suppressor of ccRCC progression that transcriptionally represses GPX4, a central inhibitor of ferroptosis.
Chaihuang weikuining protects against ethanol-induced gastric ulcer through modulation of gut microbiota and inhibition of JAK1/STAT3 signaling
Abstract Background: Chaihuang weikuining (CHWKN) is a traditional Chinese medicinal formula with reported anti-ulcer activity. However, the underlying mechanisms remain unclear. This study aimed to investigate the protective effects of CHWKN against ethanol-induced gastric ulcer (GU) and to explore the role of gut microbiota in mediating these effects. Methods: An ethanol-induced GU model was established in rats.
Assessing spatio-temporal coupling between intangible cultural heritage and rural development in China (2013–2022) through coupling coordination analysis and random-forest prediction
Abstract This study analyzes panel data from 31 provinces in China spanning 2013 to 2022, employing the entropy value approach and the coupling coordination degree model to assess the coupling coordination level between intangible cultural heritage and rural development. Data sourced from the China Cultural Heritage and Tourism Statistical Yearbook, the National Bureau of Statistics of China, and other official data.
Computer Science > Robotics
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zkFinGPT: Zero-Knowledge Proofs for Financial Generative Pre-trained Transformers
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
[2512.08270] Reasoning Models Ace the CFA Exams
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Transcriptomic analysis reveals TME-mediated macrophage IFIT1 upregulation and CX3CR1 suppression drive osteosarcoma progression
1 Introduction Osteosarcoma (OS), a highly prevalent primary bone malignancy, predominantly occurs in adolescents and young adults (1). Despite multimodal therapies, the prognosis for patients with OS remains poor due to tumor heterogeneity and complex molecular mechanisms (2, 3).
MUC1-C auto-regulatory complex with EBNA1 is responsible for latent Epstein-Barr virus-associated gastric cancer progression - Oncogene
Abstract Latent Epstein-Barr Virus (EBV) infection promotes cancers derived from B-lymphocytes and epithelial cells by mechanisms that largely remain unclear. EBV-encoded nuclear antigen 1 (EBNA1) is uniformly expressed in EBV-associated cancers; however, how EBNA1 contributes to cancer progression is not known. The MUC1 gene evolved in mammals to protect barrier tissues from viral infections. We report that MUC1 is upregulated in EBV-associated gastric cancers (EBVaGCs).
Optimization of Sodium Alginate‐Based Biomimetic Artificial Muscle Assembly Process and Multidimensional Evaluation System for Output Force Performance
Conflicts of Interest The authors declare no conflicts of interest. References 1, , and , “A Review on Recent Trends of Bioinspired Soft Robotics: Actuators, Control Methods, Materials Selection, Sensors, Challenges, and Future Prospects,” Advanced Intelligent Systems 7 (2024): 2400414, https://doi.org/10.1002/aisy.202400414.
Impact of Recurrence on Survival Prognosis in Myxofibrosarcoma: A Sing
Qinghe Guo,1– 4,* Xianming Xu,5,* Zhengming Yang,1– 4 Keyi Wang,1,2 Jiadan Wu,1,2 Bing Liu,1– 4 Huimin Tao,1– 4 Zhaoming Ye1– 4 1Department of orthopedics, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, 310000, People’s Republic of China; 2Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang Province, 310000, People’s Republic of China; 3Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, 310000, People’s...
Whether unplanned excision on synovial sarcoma will influence the prognosis? An retrospective analysis of prognostic factors in 54 synovial sarcoma cases at a single center
Ayuda Buscar en la ayuda Buscar en la ayuda Whether unplanned excision on synovial sarcoma will influence the prognosis? An retrospective analysis of prognostic factors in 54 synovial sarcoma cases at a single center Qinghe Guo [1] ; ZhengMing Yang [1] ; KeYi Wang [1] ; JiaDan Wu [1] ; Bing Liu [1] ; Nong Lin [1] ; HuiMin Tao [1] ; ZhaoMing Ye [1] [1] Second Affiliated Hospital of Zhejiang University Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 27, Nº. 2, 2025, págs.
Precise Detection of NSE and ProGRP with Nanoprobe for Early Diagnosis of Small Cell Lung Cancer
Precise Detection of NSE and ProGRP with Nanoprobe for Early Diagnosis of Small Cell Lung Cancer A DNA strand-based fluorescent nanoprobe was developed for the direct simultaneous detection of small cell lung cancers’ tumor markers NSE and ProGRP. The nanoprobe offers stability, simplicity, and rapid response, making it highly promising for application in clinical serum samples’ diagnosis. You have access to this article This article has not yet been cited.
NanoTrackThera Platform for Real‐Time, In Situ Monitoring of Tumor Immunotherapy and Photothermal Synergistic Efficacy
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202411705-sup-0001-SuppMat.docx3.5 MB Supporting Information References 1, , , , , , , , , , , , , , J. Clin. Oncol. 2016, 34, e20001. 2, , , , , Nat. Med. 2019, 25, 377. 3, , , , , , , , Ann. Oncol. 2019, 30, iv101. 4, J. R. Soc. Med. 2018, 112, 133. 5, , , , Semin. Cancer Biol. 2022, 86, 420. 6, , , Biomed. Pharmacother. 2018, 106, 1586. 7, , , , , , Adv. Funct. Mater. 2021, 31, 2107540. 8, , , Ann. Oncol.
Soil polluted system shapes endophytic fungi communities associated with Arundo donax: a field experiment
Soil polluted system shapes endophytic fungi communities associated with Arundo donax: a field experiment Guangxi Key Laboratory of Plant Conservation and Restoration Ecology in Karst Terrain, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin, China DOI 10.7717/peerj.18789 Academic Editor Anastazia Banaszak Subject Areas Ecology, Mycology, Soil Science, Ecotoxicology, Environmental Contamination and Remediation Keywords Contaminated soil,...
A Novel Method for Estimating State of Power of Lithium-Ion Batteries Considering Core Temperature
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A Combined Transcriptomic and Proteomic Analysis of Monkeypox Virus A23 Protein on HEK293T Cells
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MUC1-C regulates NEAT1 lncRNA expression and paraspeckle formation in cancer progression - Oncogene
Abstract The MUC1 gene evolved in mammals for adaptation of barrier tissues in response to infections and damage. Paraspeckles are nuclear bodies formed on the NEAT1 lncRNA in response to loss of homeostasis. There is no known intersection of MUC1 with NEAT1 or paraspeckles. Here, we demonstrate that the MUC1-C subunit plays an essential role in regulating NEAT1 expression. MUC1-C activates the NEAT1 gene with induction of the NEAT1_1 and NEAT1_2 isoforms by NF-κB- and MYC-mediated mechanisms.
Investigation of the influence of nano ZnO particle doping in electrode membrane on the output characteristics of biomimetic artificial muscles
REFERENCES 1, . A review of ionic polymeric soft actuators and sensors. Soft Robot. 2014; 1:38-52. doi:10.1089/soro.2013.0006 2Zhang H, Lin Z, Hu Y, et al. Low-voltage driven ionic polymer-metal composite actuators: structures, materials, and applications. Adv Sci. 2023; 10:e2206135. doi:10.1002/advs.202206135 3, , , et al. Shape-memory polymeric artificial muscles: mechanisms, applications and challenges. Molecules. 2020; 25. doi:10.3390/molecules25184246 4, , , . What is an artificial muscle?
XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression - Cell Death & Disease
Abstract The long non-coding RNA X-inactive specific transcript (lncRNA XIST) and MUC1 gene are dysregulated in chronic inflammation and cancer; however, there is no known interaction of their functions. The present studies demonstrate that MUC1-C regulates XIST lncRNA levels by suppressing the RBM15/B, WTAP and METTL3/14 components of the m6A methylation complex that associate with XIST A repeats.
Fabrication of liquid crystal Fe3O4 composites and their magnetorheological properties
REFERENCES 1, , , . Fabrication of magnetite nanoparticle-embedded polystyrene composites and their additive role on the dynamic properties of carbonyl iron-based magneto-rheological fluids. J Magn. 2019; 24: 162-167. 2, , , . Magnetic polymer composite particles: design and magnetorheology. Polymers. 2021; 13: 512. 3, , , , , . Terahertz linear polarizers fabricated using magnetorheological fluid. Opt Mater. 2021; 121:111644. 4, , , . Methods for sedimentation study of magnetorheological fluids.
Advancing Nonsmall Cell Lung Cancer Diagnosis Accuracy via Dual Detection Fluorescent Nanoprobes
Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Composition‐Reinforced Polydopamine Nanoenzyme for Improved Impairment of Prostatitis‐Damaged Sexual Behavior and Enhanced Anti‐Prostate Cancer
Conflict of Interest The authors declare no conflict of interest.
Composition‐Reinforced Polydopamine Nanoenzyme for Improved Impairment of Prostatitis‐Damaged Sexual Behavior and Enhanced Anti‐Prostate Cancer
Conflict of Interest The authors declare no conflict of interest.
Analysis of the Impact of Electrochemical Properties of Copper-Doped Electrode Membranes on the Output Force of Biomimetic Artificial Muscles
1. Introduction In recent years, biomimetic artificial muscles (BMAMs) fabricated from electroactive polymers have garnered substantial attention within the academic community [1]. These synthetic muscles exhibit a distinctive capability to undergo deformation or generate motion when subjected to an external electric field, potentially offering a substantial simplification of conventional mechanical actuation mechanisms [2].
Reactive X (where X = O, N, S, C, Cl, Br, and I) species nanomedicine
Reactive X (where X = O, N, S, C, Cl, Br, and I) species nanomedicine Reactive oxygen, nitrogen, sulfur, carbonyl, chlorine, bromine, and iodine species (RXS, where X = O, N, S, C, Cl, Br, and I) have important roles in various normal physiological processes and act as essential regulators of cell metabolism; their inherent biological activities govern cell signaling, immune balance, and tissue homeostasis.
Bioinspired Artificial Muscles Based on Sodium Alginate-Wrapped Multi-Walled Carbon Nanotubes and Molybdenum Disulfide Composite Electrode Membrane
1. Introduction In recent years, biomimetic artificial muscles (BMAMs) have attracted considerable attention due to their remarkable mechanical properties such as excellent flexibility, bending capability, and stretchability [1]. These characteristics enable BMAMs to simplify mechanical structures and improve energy conversion efficiency [2], providing broad prospects for their applications in flexible electronics, robotics, wearable devices, and other fields [3,4,5].
Cuproptosis-related MTF1 inhibits kidney renal clear cell carcinoma progression by suppressing proliferation and regulating immune cell infiltration
1. INTRODUCTION Renal cancer is one of the most common urinary tract malignancies originating from renal tubular epithelial cells. Renal cancer accounts for 2.2% of all malignant tumors, with renal clear cell carcinoma (KIRC) the most common type of renal cancer [1, 2].
Remote Sensing | Free Full-Text | Long-Term Tibetan Alpine Vegetation Responses to Elevation-Dependent Changes in Temperature and Precipitation in an Altered Regional Climate: A Case Study for the Three-Rivers Headwaters Region, China
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Polydopamine-modified decellularized intestinal scaffolds loaded with adipose-derived stem cells promote intestinal regeneration
Polydopamine-modified decellularized intestinal scaffolds loaded with adipose-derived stem cells promote intestinal regeneration† Jian Wan, *abc Tianqi Wu,*a Keyi Wang,d Kai Xia,a Lu Yin‡a and Chunqiu Chen‡a Abstract Regeneration of gastrointestinal tissues remains a great challenge due to their unique microenvironment. Functional composite decellularized scaffolds have shown great potential in gastrointestinal repair and inducing gastrointestinal tissue-specific proliferation.
Polydopamine-modified Decellularized Intestinal Scaffolds Loaded with Adipose-Derived Stem Cells Promote Intestinal Regeneration
Polydopamine-modified Decellularized Intestinal Scaffolds Loaded with Adipose-Derived Stem Cells Promote Intestinal Regeneration Jian Wan, Tianqi Wu, Keyi Wang, Kai Xia, Lu Yin and Chunqiu Chen Abstract Regeneration of gastrointestinal tissues remains a great challenge due to their unique microenvironment. Functional composite decellularized scaffolds have shown great potential in gastrointestinal repair and inducing gastrointestinal tissue-specific proliferation.
Cutting Edge: Neutrophils License the Maturation of Monocytes into Effective Antifungal Effectors
Key Points Monocytes have impaired antifungal effector function in neutropenic mice. STAT1 expression on CCR2+ monocytes is required for defense against IA. Neutrophils are a relevant direct source of IFN-γ during aspergillosis. Abstract Neutrophils are critical for the direct eradication of Aspergillus fumigatus conidia, but whether they mediate antifungal defense beyond their role as effectors is unclear.
Cutting Edge: Neutrophils License the Maturation of Monocytes into Effective Antifungal Effectors
Key Points Monocytes have impaired antifungal effector function in neutropenic mice. STAT1 expression on CCR2+ monocytes is required for defense against IA. Neutrophils are a relevant direct source of IFN-γ during aspergillosis. Abstract Neutrophils are critical for the direct eradication of Aspergillus fumigatus conidia, but whether they mediate antifungal defense beyond their role as effectors is unclear.
Effect of Dissipation on the Moonpool-Javelin Wave Energy Converter
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited.
Engineering Ultrasmall Ferroptosis‐Targeting and Reactive Oxygen/Nitrogen Species‐Scavenging Nanozyme for Alleviating Acute Kidney Injury
Research Article Keyi Wang, Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200060 P. R. China Search for more papers by this author Yang Zhang, Nanotechnology and Intestinal Microecology Research Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072 P. R. China Precision Medicine Center, Taizhou Central Hospital, Taizhou, Zhejiang, 318000 P. R.
Can Authenticity Drive Bottom-Line? This Startup Shows You How (Part I)
This story is part of the Entrepreneurship of Life series, a collection of interviews with immigrant startup founders, venture capitalists, and tech business leaders. Introduction We talk a lot about founder-market fit for startups, but even so, you don’t often speak to founders for five minutes and get the feeling that, in a way, they are exactly what they build. Alan is one such founder.
A Heat-Killed Cryptococcus Mutant Strain Induces Host Protection against Multiple Invasive Mycoses in a Murine Vaccine Model
Research Article | Host-Microbe Biology Yina Wang, Keyi Wang, Jorge A. Masso-Silva, Amariliz Rivera, Chaoyang Xue Stuart M. Levitz, Invited Editor, Tamara L. Doering, Editor DOI: 10.1128/mBio.02145-19 ABSTRACT Cryptococcus neoformans is a fungal pathogen that infects the lungs and then often disseminates to the central nervous system, causing meningitis. How Cryptococcus is able to suppress host immunity and escape the antifungal activity of macrophages remains incompletely understood.
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