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ResourceVolume 19, Issue 8p1217-1232Open access 1Centre for Stem Cell Biology, School of Biosciences, The University of Sheffield, Sheffield, UK 2Neuroscience Institute, The University of Sheffield, Sheffield, UK 3INSIGNEO Institute, The University of Sheffield, Sheffield, UK 4WiCell Research Institute, Madison, WI, USA 5Department of Human Genetics, University of Chicago, Chicago, IL, USA 6Department of Human Molecular Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel...
Abstract Since the first derivation of human pluripotent stem cells (hPSCs), the number of culture conditions has steadily increased, making hPSC culture more facile. Nonetheless, there remains the persistent issue of culture-acquired genetic changes, hampering the reproducibility of hPSC research and jeopardising their clinical use.
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