Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Get in touch with Dylan
Contact Dylan, search articles and posts on X, monitor coverage, and track replies from one place.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Highlights • Increase in chromosome 1q gains in recent years is linked to feeder-free cultures • Feeder-free conditions (E8/vitronectin) confer high levels of genome damage on hPSC • Amplification of MDM4 on chromosome 1q alleviates genome damage-induced apoptosis • Karyotypically abnormal cells have a context-dependent selective advantage Summary Culture-acquired variants in human pluripotent stem cells (hPSCs) hinder their applications in research and clinic.
ResourceVolume 19, Issue 8p1217-1232Open access 1Centre for Stem Cell Biology, School of Biosciences, The University of Sheffield, Sheffield, UK 2Neuroscience Institute, The University of Sheffield, Sheffield, UK 3INSIGNEO Institute, The University of Sheffield, Sheffield, UK 4WiCell Research Institute, Madison, WI, USA 5Department of Human Genetics, University of Chicago, Chicago, IL, USA 6Department of Human Molecular Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel...
Abstract The genetic integrity of pluripotent stem cells (PSC) is integral to their applications in research and therapy, but it is compromised by frequent development of copy number variations. Little is known about the basis of the variable genomic integrity among different PSC lines. Here we identify aneuploidies using RNA-seq and proteomics data from a panel of mouse embryonic stem cell (mESC) lines derived from 170 Diversity Outbred mice.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
