John Cleveland
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Articles by John Cleveland
Unc-51 like kinase 3 (ULK3) contributes to autophagy and cell survival in multiple myeloma
Abstract Despite effective therapies such as proteasome inhibitors, multiple myeloma (MM) patients relapse with refractory disease. Analysis of RNA sequencing data from CD138 + MM patient cells (n = 813) across disease stages identifies an autophagy gene signature. Particularly elevated ULK3 expression is strongly associated with disease progression. Functional studies reveal that ULK3 supports MM cell survival via the ULK-ATG13-FIP200 complex.
Commentor writes Senate panel rightly omits Save Our Bacon from farm bill
The Senate Agriculture Committee has released its long-awaited version of the farm bill, and Sens. Chuck Grassley and Joni Ernst of Iowa now face an important choice. kAmu@CEF?2E6=J[ $6?2E6 #6AF3=:42?D >256 E96 C:89E @?6 :? E96:C :?:E:2= 5C27Ej F?=:<6 E96 w@FD6\A2DD65 72C> 3:==[ E96 $6?2E6 AC@A@D2= 5@6D ?@E :?4=F56 #6A] pD9=6J w:?D@? @7 x@H2’D “$2G6 ~FC q24@? p4E” @C :ED $6?2E6 4@F?E6CA2CE[ tC?DE’D “u@@5 $64FC:EJ 2?5 u2C> !C@E64E:@? p4E]” %92E @>:DD:@? D9@F=5 C6>2:?
Senate panel rightly omits Save Our Bacon from farm bill | Opinion
Many farmers have already invested substantial resources to comply with these standards and access those markets. John Cleveland Guest columnist June 28, 2026, 7:04 a.m. CT John Cleveland is a senior fellow at Wilberforce Institute, a nonprofit formed in 2024. The Senate Agriculture Committee has released its long-awaited version of the farm bill, and Sens. Chuck Grassley and Joni Ernst of Iowa now face an important choice.
Roger Marshall’s right on animal welfare. Pork producers should follow him | Opinion
This debate is no longer primarily about preventing cruelty to livestock. It is about respect for state decision-making. In Washington, D.C., changing your mind can be portrayed as weakness. In reality, it is often a sign of leadership. That is why Sen. Roger Marshall deserves credit for withdrawing his support from the Food Security and Farm Protection Act, legislation that would override state farm animal welfare laws such as California’s Proposition 12.
Commentary: SC’s health and sovereignty at stake in new federal farm bill
South Carolina has a host of regulations governing the production of farm animals. These rules protect the people of the Palmetto State by, for example, prohibiting the importation of cattle and poultry without certain health certifications.
Cleveland and Irby: The hidden costs of ‘Saving Our Bacon’
Getting your Trinity Audio player ready... Americans across the political spectrum are understandably steamed about the “Save Our Bacon Act,” included in the new Farm Bill despite nearly a decade of legal and legislative renunciations. Most already know the familiar arguments against it. Animal welfare advocates say it entrenches wantonly cruel industrial farming practices. National security hawks say it gives a free pass to Chinese-owned agricultural interests.
Learn to fly fish with the experts!
Legendary journalist and avid fly fisherman Tom Brokaw once said of fly fishing, “If fishing were a religion, fly fishing would be high church.” What more could we ask for in a sport? My fishing friends and I would even suggest, by Tom’s analogy, there are often legitimate reasons during the trout season to skip a few regularly scheduled brick-and-mortar Sunday church services without the fear of eternal damnation.
Corporate Ag is losing - and the right is waking up
With the clock running out on a new Farm Bill, large lobbying interests are once again gathering at the government trough, hoping to use any prospective legislation to overturn California’s seven-year-old farm animal welfare law, Proposition 12. But this time, something unusual is happening: small farmers and conservatives are pushing back.
Lymphoma accelerates T cell and tissue aging
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Keywords B cell lymphoma T cell NK cell aging ferroptosis Introduction Aging greatly increases cancer risk1 and has profound effects on the function and composition of the immune system, leading to impaired immune responses to chronic and acute infections and a predisposition to autoimmune diseases.2 Aging-driven changes to the immune system are many, and include imbalances in inflammatory cytokines and chemokines (inflammaging)3 and secretory phenotypes,4 a skewing of hematopoietic stem...
By Rebecca S. Hesterberg, Joshua Davis, Komal J. Handoo, Aya G. Elmarsafawi, Anthony Augello, Chia-Ho Cheng, Reginald Atkins, Dae Hyun Lee, Chunying Yang, Jiqiang Yao, Krishna Patel, Melanie Mediavilla-Varela, Javier Pinilla-Ibarz, Carolina Soto-Palma, Frederick Locke, Xiaofei Song, Xuefeng Wang, Anders Berglund, Paulo C. Rodriguez, Gero Knittel, Ruth Flümann, Hans Reinhardt, Timothy Shaw, Xiaoqing Yu, Laura J. Niedernhofer, John Cleveland Verified
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Cell Press
Verified
Egg prices are still high. Roger Marshall's trying to make them more expensive Original
His bill would let huge corporate agricultural interests - like China-owned Smithfield Food - outcompete most small farmers. Joseph Scheller/Columbus Dispatc Whether hard-boiled or sunny-side up, eggs are top of mind for millions of American families. From nationally renowned heists to viral videos, the issue has become central to sticker-shocked voters concerned about affordability. But Americans are being deceived about the true cause of higher egg prices.
Congressional agriculture committees prioritize profits over small farmers Original
It’s never been clearer where the loyalties of congressional agriculture committees lie.
Ending Corruption in Agriculture
The House Agriculture Committee’s reconciliation plan cuts millions in SNAP benefits to offer ever more subsidies to struggling farmers, who haven’t seen a new Farm Bill since 2018. Instead of simply moving money around -- much to the detriment of states and their poorest residents -- congressional agriculture advocates ought to address some of the underlying, substantive issues plaguing small and independent farmers.
Congress Keeps Trying to Overturn State Agriculture Laws
Whatever you think of tariffs, it should be clear that now is not the time to introduce more uncertainty into agricultural markets. The “Food Security and Farm Protection Act” (S. 1326) — recently introduced in the United State Senate — would do exactly that, giving foreign adversaries like China an even bigger chokehold on American agricultural production while harming producers and principles of state sovereignty in the process. S.
Op-Ed: Impounding Animal Abuse: The Moment for Animal-Loving Conservatives
Whatever you think about Trump’s accomplishments during these first tumultuous weeks, we’ve seen a marked uptick in government recognition of right-leaning voices concerned about the billions of animals routinely subjected to torture and abuse at our hands. kA DEJ=6lQ7@?E\H6:89Ei c__jQmr@?D:56C (9:E6 r@2E (2DE6 W(r(X[ 2 H2E495@8 @C82?:K2E:@? 565:42E65 E@ 6?5:?8 E2IA2J6C\7F?565 2?:>2= 6IA6C:>6?E2E:@?] (r( H2D E96 7:CDE 8C@FA E@ 3C:?8 E@ 2EE6?E:@? E96 ?@H\?@E@C:@FD Sg >:==:@? :?
Impounding Animal Abuse: The Moment for Animal-Loving Conservatives
President Trump has declared that America is “woke no longer.” Let’s hope he’s correct because it’s long past time that activists of all political backgrounds get back to tangible issues with real impact. For those of us on the political right who happen to love animals, it’s time to step up.
Impounding Animal Abuse: The Moment for Animal-Loving Conservatives
President Trump has declared that America is “woke no longer.” Let’s hope he’s correct because it’s long past time that activists of all political backgrounds get back to tangible issues with real impact. For those of us on the political right who happen to love animals, it’s time to step up.
Preservation of Cardiac Xenografts in a Model of Infant Human Cardiac Transplantation
Trump's Cabinet lineup so far is surprisingly pro-animal
John Cleveland is a public affairs professional and senior fellow at Wilberforce Institute . He previously worked for the Humane Society of the United States. Pop quiz. Upon signing one of the most important federal animal welfare laws in U.S. history, a former president said: "We have a responsibility to honor the dignity of God's creation.
Early Results of an Infant Model of Orthotopic Cardiac Xenotransplantation
Glossary of Abbreviations ANOVA (Analysis of Variance) CRP (C-reactive protein) GEP (genetically engineered pigs) IS (Immunosuppression) IFNG (interferon gamma) IL-1b (interleukin-1b) IL-8 (interleukin-8) IL-6 (interleukin-6) LDH (lactate dehydrogenase) LV (left ventricle) LVEDP (left ventricle end-diastolic pressure) MUF (modified ultrafiltration) MCP1 (monocyte chemoattractant protein-1) MIG (monokine induced by interferon gamma) NHP (non-human primate) OCXT (orthotopic cardiac...
John Cleveland's Holiday Cookies Original
For John Cleveland, who runs Post & Beam in the Baldwin Hills Crenshaw Plaza with wife Roni Cleveland, Thanksgiving season begins with his mincemeat cookies.
Immunisation deferral practices surrounding congenital heart surgery
Perioperative immunisation administration surrounding surgery for CHD is controversial. Children with CHD are at risk for under-vaccination. Predictors of under-vaccination in this population include prolonged hospitalisation(s) during the first year of life, primary care in a state other than where they receive their cardiac care, multiple comorbidities, and cardiac surgery requiring cardiopulmonary bypass.
Big Agriculture skirts the law and the Constitution to fight animal welfare
Alabama’s ban on the sale of cultivated meat goes into effect this month, with violators facing a $500 fine and up to three months in jail. It’s a stunningly anti-free market sop to the in-state meat industry and a likely violation of the Interstate Commerce Act, which prohibits states from unduly burdening the free flow of commerce across state lines. Yet, it’s nothing new for big agricultural interests in their ongoing fight against pro-animal products and compassionate welfare reforms.
The Many Faces of Hypusinated eIF5A: Cell Context-Specific Effects of the Hypusine Circuit and Implications for Human Health
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
The Rising Tide: The Economic Impact on Housing
In our time, the challenge of climate change has risen to the forefront, unleashing a chain of consequences, notably extreme weather events that disrupt our communities and infrastructure. As these climate-driven disasters grow more frequent and severe, it becomes clear that their toll extends beyond the visible damage, encompassing significant financial ramifications.
What is the Riskiest Region in the US as the Climate Changes?
Hurricane Nicole damaged the world's most famous beach in Florida, Daytona Beach, in November 2022. I later dodged this storm in Nova Scotia before heading back to Florida, where Hurricane Ian had just devastated Fort Meyers Beach, Florida, just days before. In 2021, the United States witnessed the impact of natural hazards on nearly one in 10 homes. As climate change continues to shape our environment, it becomes imperative to identify the riskiest regions in the country.
Programming inactive RNA-binding small molecules into bioactive degraders - Nature
Abstract Target occupancy is often insufficient to elicit biological activity, particularly for RNA, compounded by the longstanding challenges surrounding the molecular recognition of RNA structures by small molecules. Here we studied molecular recognition patterns between a natural-product-inspired small-molecule collection and three-dimensionally folded RNA structures. Mapping these interaction landscapes across the human transcriptome defined structure–activity relationships.
Moffitt Researchers Discover Pathway Critical for Lymphoma Development
TAMPA, Fla. — MYC proteins are important regulators of cancer cell growth, proliferation and metabolism through their ability to increase the expression of proteins involved in these processes. Deregulation of MYC proteins occurs in more than half of all cancers and is associated with poor patient prognosis and outcomes. Numerous researchers have devoted significant efforts to try to target MYC proteins as a therapeutic approach to treat cancer.
Webinar: Strategies for Adding Value and Building a Strong Biotech Patent Portfolio - Sponsored by CAS
« All Events - 1:00 pm EDT Free The process for developing new biotech therapies can easily put R&D and intellectual property leaders in uncharted territory. From lead selection to freedom to operate, it is not unusual to request a dozen patent and scientific literature searches to help guide researchers as they attempt to maximize value and opportunity. Collaboration, communication, and thorough research facilitate the innovation to commercialization lifecycle.
Severe Ebstein's Anomaly in a Premature, Low Weight Neonate
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The Bootleg Series Vol 4 Bob Dylan Live 1966 The Royal Albert Hall Concert (15 tracks) +Album Reviews
Get your own copy of this album at SwapaCD.com. If you're not yet a member, your first 2 cds and membership are free! All you have to do is post 10 cds you want to get rid of.
Is The Amazon Rainforest On The Verge Of Collapse?
Dr Morley Read/Shutterstock Sprawling 5.5 million square kilometres, the Amazon rainforest is the largest of its kind and home to about one in ten of all known species. To date, at least 40,000 plants, 2,200 fish, 1,200 birds, 400 mammals, 400 amphibians, and 375 reptiles have been scientifically classified in the region, not to mention nearly 2.5 million insect species. The Amazon has existed as a dense and humid rainforest teeming with life for at least 55 million years.
Ancient Sludge Under Permafrost Indicates Earth’s Future
Using lake sediment in the Tibetan Plateau, researchers show that permafrost at high elevations is more vulnerable than arctic permafrost under projected future climate conditions. From the ancient sludge of lakebeds in Asia’s Tibetan Plateau, scientists can decipher a vision of Earth’s future. That future, it turns out, will look very similar to the mid-Pliocene warm period—an epoch 3.3 million to 3 million years ago when the average air temperature at mid-latitudes rarely dropped below freezing.
Why Dixie Is The New Tornado Alley
The heart of U.S. tornado activity, once Tornado Alley, has shifted eastward. Brent Koops/NOAA Weather in Focus Photo Contest 2015, CC BY-ND Tornadoes tore up homes in New Orleans and its suburbs and were reported in communities from Texas to Mississippi and Alabama as severe storms swept across the South in late March 2022.
Record-smashing Heatwaves Are Hitting Antarctica and The Arctic Simultaneously
Early melting of Arctic ice sheets could have dire consequences for polar bears. Shutterstock Record-breaking heatwaves hit both Antarctica and the Arctic simultaneously this week, with temperatures reaching 47℃ and 30℃ higher than normal. Heatwaves are bizarre at any time in Antarctica, but particularly now at the equinox as Antarctica is about to descend into winter darkness. Likewise, up north, the Arctic is just emerging from winter. Are these two heatwaves linked?
Repeated Coral Bleaching Leaves Wildlife With Few Options
Grumpy Turtle Films, Author provided To our horror, another mass coral bleaching event may be striking the Great Barrier Reef, with water temperatures reaching up to 3℃ higher than average in some places. This would be the sixth such event since the late 1990s, and the fourth since 2016. It comes as a monitoring mission from the United Nations arrives in Queensland today to inspect the reef and consider listing the World Heritage site as “in danger”.
What To Expect As Pollen Season Gets Longer And More Intense With Climate Change
Ragweed pollen grains, magnified and colorized. Bob Sacha/Corbis Documentary via Getty Images Brace yourselves, allergy sufferers – new research shows pollen season is going to get a lot longer and more intense with climate change. Our latest study finds that the U.S. will face up to a 200% increase in total pollen this century if the world continues producing carbon dioxide emissions from vehicles, power plants and other sources at a high rate.
Is It Time To Change The Definition Of Drought To Normal?
"If we're never returning to normal, then we need to adapt all of the ways that we manage water with the expectation that normal will continually be drier and drier every year," says Samantha Stevenson. (Credit: Md. Hasanuzzaman Himel/Unsplash) In coming decades, many regions of the world will enter permanent dry or wet conditions under modern definitions of drought, according to new research.
Megacities Will Need More Than Just Flood Barriers
Many of the world’s poorest people live in regions most susceptible to flooding. In northeast India, some residents have been forced to rebuild their homes at least eight times in the past decade. In Africa, the continent’s largest city, Lagos in Nigeria, may become unliveable due to severe floods, while a recent flood caused by tropical storm Ana affected hundreds of thousands of people across the south of the continent.
Megacities Will Need More Than Just Flood Barriers
Many of the world’s poorest people live in regions most susceptible to flooding. In northeast India, some residents have been forced to rebuild their homes at least eight times in the past decade. In Africa, the continent’s largest city, Lagos in Nigeria, may become unliveable due to severe floods, while a recent flood caused by tropical storm Ana affected hundreds of thousands of people across the south of the continent.
Why Farmers Are Increasingly Worried About Climate
Climate change means extreme events such as floods, bushfires and droughts will become more frequent and severe. Those events will disrupt food supply chains, as people along Australia’s sodden east coast have seen again in recent weeks. Australia certainly isn’t at risk of running out of food. It produces far more food than it consumes, with around of farm production exported. What is at risk is Australia’s ability to distribute it.
How The Little Ice Age Devastated Early Modern Europe
Weary hunters return from an expedition with little to show for it in the 1565 Dutch painting, Hunters in the Snow. This isn’t the first time that Britain has experienced drastic climate change, however. By the 16th and 17th centuries, northern Europe had left its medieval warm period and was languishing in what is sometimes called the little ice age. Starting in the early 14th century, average temperatures in the British Isles cooled by 2°C, with similar anomalies recorded across Europe.
Why It's Important That Mountain Glaciers May Hold Less Ice Than Once Thought
Mountain glaciers are under threat from global warming. Phunjo Lama/AFP via Getty Images Mountain glaciers are essential water sources for nearly a quarter of the global population. But figuring out just how much ice they hold – and how much water will be available as glaciers shrink in a warming world – has been notoriously difficult. In a new study, scientists mapped the speed of over 200,000 glaciers to get closer to an answer.
Hemodynamically efficient artificial right atrium design for univentricular heart patients
Abstract Infants born with single-ventricle physiologies pose significant challenges for mechanical circulatory support devices. Their corresponding Fontan circulations consist of passive blood flow that returns to the lungs via direct connections to the pulmonary arteries without a pumping chamber. When Fontan patients reach adolescence or young adulthood, they tend to develop heart failure and may require heart transplants and/or mechanical assist devices.
Epidemiology, Time Trends, and Outcomes of Serious Infections in Patients With Vasculitis: A Nineteen‐Year National Study
Brief Report Jasvinder A. Singh, Corresponding Author Jasvinder.md@gmail.com orcid.org/0000-0003-3485-0006 Birmingham VA Medical Center, Birmingham, Alabama and University of Alabama at Birmingham Address correspondence to Jasvinder A. Singh, MBBS, MPH, University of Alabama at Birmingham, Faculty Office Tower 805B, 510 20th Street S, Birmingham, AL 35294-0022. Email: Jasvinder.md@gmail.com.Search for more papers by this author John D.
What’s going on inside the veins of trees dying of thirst in a drought?
Juniper trees, common in Arizona's Prescott National Forest, have been dying with the drought. Benjamin Roe/USDA Forest Service via AP Like humans, trees need water to survive on hot, dry days, and they can survive for only short times under extreme heat and dry conditions. During prolonged droughts and extreme heat waves like the Western U.S. is experiencing, even native trees that are accustomed to the local climate can start to die.
Hot nights mess up rice’s internal clock
New research clarifies how hot nights are curbing crop yields for rice. “Essentially, we found that warmer nights throw the rice plant’s internal clock out of whack,” says Colleen Doherty, an associate professor of biochemistry at North Carolina State University and corresponding author of a paper on the work in the journal PNAS. “Most people think plants aren’t dynamic, but they are.
Serious Infections in Patients With Gout in the US: A National Study of Incidence, Time Trends, and Outcomes
Original Article Jasvinder A. Singh, Corresponding Author Jasvinder.md@gmail.com orcid.org/0000-0003-3485-0006 VAMC, Birmingham, Alabama and University of Alabama at Birmingham Address correspondence to Jasvinder A. Singh, MBBS, MPH, University of Alabama at Birmingham, Faculty Office Tower 805B, 510 20th Street S, Birmingham, AL 35294. Email: Jasvinder.md@gmail.com. Search for more papers by this author John D. Cleveland, 1Jasvinder A.
Another Dangerous Fire Season Is Looming In The Western US
Audio Version Just about every indicator of drought is flashing red across the western U.S. after a dry winter and warm early spring. The snowpack is at less than half of normal in much of the region. Reservoirs are being drawn down, river levels are dropping and soils are drying out. It’s only May, and states are already considering water use restrictions to make the supply last longer. California’s governor declared a drought emergency in 41 of 58 counties.
How Bad Could Our Climate Future Be If We Do Nothing?
Lumppini/Shutterstock The climate crisis is no longer a looming threat – people are now living with the consequences of centuries of greenhouse gas emissions. But there is still everything to fight for. How the world chooses to respond in the coming years will have massive repercussions for generations yet to be born. In my book How to Save Our Planet, I imagine two different visions of the future. One in which we do very little to address climate change, and one in which we do everything possible.
How Bad Could Our Climate Future Be If We Do Nothing?
Lumppini/Shutterstock The climate crisis is no longer a looming threat – people are now living with the consequences of centuries of greenhouse gas emissions. But there is still everything to fight for. How the world chooses to respond in the coming years will have massive repercussions for generations yet to be born. In my book How to Save Our Planet, I imagine two different visions of the future. One in which we do very little to address climate change, and one in which we do everything possible.
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