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Lachlan Dryburgh

As seen in: Nature, Cell Press
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Articles

Stem-like precursors of exhausted Th cells upheld by a Tox-Myb-Eomes transcriptional hierarchy propagate Th cell responses in chronic infection

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By Lifen Wen, Chun-Hsi Su, Nikita Potemkin, Lachlan Dryburgh, Lei Qin, Marcela De Lima Moreira, Ashraful Haque, Xiye Sun, Vincenzo Cinella, Jan Schroeder, Carlson Tsui, Axel Kallies
| Cell Press Verified
Keywords CD4+ T cells lymphocytic choriomeningitis virus LCMV checkpoint inhibition exhaustion PD-1 Introduction Conventional CD4+ T cells are pivotal for supporting the adaptive immune response against pathogens by eliciting a wide array of helper and effector functions.1,2,3,4 Upon antigen encounter, activated CD4+ T cells rapidly expand and differentiate into different types of T helper (Th) cells depending on the cytokine milieu they encounter.
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Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma

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By Annabell Bachem, Michele Clarke, Lachlan Dryburgh, Lindsay Kosack, Ariane Lee, Lewis D. Newland, Teagan Wagner, Emma Bawden, Kah Min Yap, Michael Wilson, Sven H. Engel, Kayla Wilson, Brendan E. Russ, Kshitij Tandon, Grant McArthur Verified, Vanessa Marcelino, Paul A. Beavis, Stephen Turner, Jason Waithman, Timothy P. Stinear, Shahneen Sandhu, Jan Schroder, Thomas Gebhardt, Sammy Bedoui, Geraldine Kong, Ilaryia Tarasova
| Cell Press Verified
Keywords CD8 T cells stemness melanoma microbiome microbiota metabolism SCFAs butyrate Get full text access Log in, subscribe or purchase for full access. References 1. Herbst, R.S. ∙ Soria, J.C. ∙ Kowanetz, M. ... Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients Nature. 2014; 515:563-567 2. Azimi, F. ∙ Scolyer, R.A. ∙ Rumcheva, P. ...
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Transcriptional regulator SATB1 limits CD8+ T cell population expansion and effector differentiation in chronic infection and cancer - Nature Immunology

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By Leonie Heyden, Michael Shannon, Lachlan Dryburgh, Marcela L. Moreira, Aleksej Frolov, Christina Scheffler, Helena Horvatic, Carlson Tsui, Laura K. Mackay, Daniel T. Utzschneider, Stephen Turner, Phillip K. Darcy, Marc Beyer, Nhat Truong Huynh-Anh
| Nature Verified
Abstract CD8+ T cells are major mediators of antiviral and antitumor immunity. During persistent antigen stimulation as in chronic infection and cancer, however, they differentiate into exhausted T cells that display impaired functionality. Precursors of exhausted T (TPEX) cells exhibit stem-like properties, including high proliferative, self-renewal and developmental potential, and are responsible for long-term CD8+ T cell responses against persistent antigens.
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