Kah Min Yap on Muck Rack

Kah Min Yap

As seen in: Nature, Cell Press
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Articles

High efficiency CRISPR knock-in demonstrates that TCF1 is insufficient to reverse T cell exhaustion - Nature Communications

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By Amanda Chen, Nihali Kulkarni, Shienny Sampurno, Kah Min Yap, Iván Pérez-Núñez, Sara Roth Verified, Christian Deguit, Brandon Haugen, Kelly M. Ramsbottom, Isabelle Munoz, Paul A. Beavis, Ian Parish, Maria N. de Menezes, Nicole Y. L. Saw
| Nature Verified
Abstract CD8+ T cell exhaustion is a regulatory state triggered by chronic antigen stimulation in both cancer and persistent infection. The less differentiated stem-like sub-populations of exhausted T cells have been heavily studied given their importance to the efficacy of current immunotherapies.
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Flt3L-mediated tumor cDC1 expansion enhances immunotherapy by priming stem-like CD8+ T cells in lymph nodes - Nature Immunology

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By Junyun Lai, Emily Derrick, Laura Carstensen, Christina Scheffler, Kevin Sek, Joelle S. Kim, Kah Min Yap, Isabelle Munoz, Dat Nguyen, Kirsten L. Todd, Maximilien Evrard, Jonathan Chee, Laura K. Mackay, Ian Parish, Anthony Bosco, Jason Waithman, Paul A. Beavis
| Nature Verified
Abstract Immune checkpoint blockade (ICB) evokes antitumor immunity through the reinvigoration of T cell responses. T cell differentiation status controls response, with less differentiated cells having an enhanced capacity to proliferate after ICB. Given that conventional type 1 dendritic cells (cDC1) maintain precursor exhausted T cells (TPEX), we hypothesized that expansion of cDC1s with Flt3L could enhance responses to ICB.
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Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma

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By Annabell Bachem, Michele Clarke, Lachlan Dryburgh, Lindsay Kosack, Ariane Lee, Lewis D. Newland, Teagan Wagner, Emma Bawden, Kah Min Yap, Michael Wilson, Sven H. Engel, Kayla Wilson, Brendan E. Russ, Kshitij Tandon, Grant McArthur Verified, Vanessa Marcelino, Paul A. Beavis, Stephen Turner, Jason Waithman, Timothy P. Stinear, Shahneen Sandhu, Jan Schroder, Thomas Gebhardt, Sammy Bedoui, Geraldine Kong, Ilaryia Tarasova
| Cell Press Verified
Keywords CD8 T cells stemness melanoma microbiome microbiota metabolism SCFAs butyrate Get full text access Log in, subscribe or purchase for full access. References 1. Herbst, R.S. ∙ Soria, J.C. ∙ Kowanetz, M. ... Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients Nature. 2014; 515:563-567 2. Azimi, F. ∙ Scolyer, R.A. ∙ Rumcheva, P. ...
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