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Articles by Lan Guo
Mitochondrial complex IV disruption is a detrimental pathology conferring ssusceptibility to alzheimer’s disease
Abstract Mitochondrial complex IV (CIV) is an integral part of the mitochondrial electron transport chain (ETC) and plays a pivotal role in maintaining mitochondrial function. In contrast to the long-standing recognition of its dysfunction in Alzheimer’s disease (AD), the exact role of CIV deficit in the pathogenesis of this neurodegenerative disorder remains poorly defined.
Context-aware multi-property antibody predictor: a novel framework integrating text and protein language models
Abstract Recent advances in Machine Learning have transformed antibody development through in silico models, accelerating therapeutic candidate identification. However, challenges persist: rapid adaptation of property predictors to laboratory-specific assays with incomplete datasets; batch effects introducing systematic bias; assay costs necessitating efficient unseen property prediction.
Peri‐operative rehabilitation bundles and postoperative pulmonary complications in elective cardiac valve surgery: a reply
We thank Ruan for their comments [1] on our randomised controlled trial evaluating a peri-operative rehabilitation bundle in patients undergoing elective cardiac valve surgery [2]. We appreciate the opportunity to respond to the points raised and clarify how our study limitations align with the suggestions offered. The absence of pre- and post-intervention lung function and diaphragm-specific assessments was already stated as a limitation.
Childhood maltreatment, exercise and transition to bipolar disorder among major depressive disorder patients - Translational Psychiatry
Abstract Early and accurate identification and management of bipolar disorders (BDs) among major depressive disorders (MDDs) in clinical practice would place these patients in progressive early-onset bipolar care. The associations between childhood maltreatment, exercise and transition from MDD to BD remain unclear. To determine whether MDD patients reporting childhood maltreatment are at an increased risk of transition to BD.
Adaptive Differential Event Detection for Space-Based Infrared Aerial Targets
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FRET-Based Dual-Color Carbon Dot Ratiometric Fluorescent Sensor Enables the Smartphone-Integrated Device for Noninvasive and Portable Diagnosis of Chronic Kidney Disease
Chronic kidney disease (CKD) is a secondary syndrome marked by high morbidity and mortality, commonly associated with diabetes mellitus, hypertension, and cardiovascular disease. (1,2) As a global health issue, CKD is predicted to be the fifth leading cause of death worldwide by 2040. (3) However, most patients with CKD are generally asymptomatic or exhibit nonspecific symptoms in the early stages, often going unnoticed until the disease progresses to a fatal end-stage disease (ESRD).
Exploration of circulating metabolic signature of erythrodermic psoriasis based on LC‐MS metabolomics
CONFLICT OF INTEREST STATEMENT None declared. Supporting Information Filename Description exd15103-sup-0001-FigureS1.docxWord 2007 document , 152.9 KB Figure S1: 98 differential metabolites identified between EP and HC represented by volcano plot. Red plots represent metabolites with higher expression in EP serum and blue plots represent metabolites with lower expression.
Effect of concomitant tricuspid annuloplasty on postoperative wound complications in heart failure patients undergoing mitral valve repair
1 INTRODUCTION Considerable controversy has arisen regarding the management of tricuspid regurgitation (TR) accompany with mitral valve diseases. Previous studies have called into question the effectiveness of the combination of tricuspid valve repair (TVR) with mitral valve surgery (MVS), as developing severe TR is not frequent.1 However, TR is mostly disregarded until it has developed a moderate or severe degree followed by heart failure, exerting a serious influence on clinical outcomes.
Switching circuits: Modulating NK cell response to TGF-β using novel receptors
Abstract Engineered natural killer (NK) cells offer a promising treatment strategy for multiple therapeutic areas, yet tuning cell function to diverse environmental and inhibitory contexts remains a significant challenge. An attractive strategy for functional rescue in the presence of inhibitory ligands is the use of switch receptors, surface-expressed chimeric receptors that convert an external inhibitory cue into an intracellular activation signal.
Naringin Protects against Non‐Alcoholic Fatty Liver Disease by Promoting Autophagic Flux and Lipophagy
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description mnfr4635-sup-0001-SuppMat.pdf687.7 KB Supporting Information mnfr4635-sup-0002-Tables.pdf35.4 KB Supporting Information References 1, , , Gut 2020, 69, 1877 2, , , , , , , , , , , , , , , , , , , , , , , , , Nat. Commun. 2021, 12, 3059. 3, , , , , , , , , , , , , , , , , , , Nat. Commun. 2019, 10, 1567. 4, , , , , , Cell Death Differ. 2020a, 27, 329. 5, , , , , , Autophagy 2021, 17, 690.
TRAFfic signals: High-throughput CAR discovery in NK cells reveals novel TRAF-binding endodomains that drive enhanced persistence and cytotoxicity
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The Corporate Economic Influence and Corporate Social Responsibility: Evidence from China
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Lan Guo 1 and Ling Yang 2,* 1 Institute of Banking and Money, Nanjing Audit University, Nanjing 211815, China 2 School of Economics and Management, Southwest Jiaotong University, Chengdu 610031, China * Author to whom correspondence should be addressed.
Mental Stress Testing in Women With Angina and No Obstructive Coronary Artery Disease
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Flexible solar cells based on foldable silicon wafers with blunted edges - Nature
Abstract Flexible solar cells have a lot of market potential for application in photovoltaics integrated into buildings and wearable electronics because they are lightweight, shockproof and self-powered. Silicon solar cells have been successfully used in large power plants. However, despite the efforts made for more than 50 years, there has been no notable progress in the development of flexible silicon solar cells because of their rigidity1,2,3,4.
Liver-expressed antimicrobial peptide 2 elevation contributes to age-associated cognitive decline
Abstract Elderly individuals frequently report cognitive decline, while various studies indicate hippocampal functional declines with advancing age. Hippocampal function is influenced by ghrelin through hippocampus-expressed growth hormone secretagogue receptor (GHSR). Liver-expressed antimicrobial peptide 2 (LEAP2) is an endogenous GHSR antagonist that attenuates ghrelin signaling.
The role of L-histidine as molecular tongs: a strategy of grasping Tb3+ using ZIF-8 to design sensors for monitoring an anthrax biomarker on-the-spot
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Colorimetric detection of Hg (II) based on the gold amalgam-triggered reductase mimetic activity in aqueous solutions by employing AuNP@MOF nanoparticles
Colorimetric detection of Hg (II) based on the gold amalgam-triggered reductase mimetic activity in aqueous solutions by employing AuNP@MOF nanoparticles Xiuli Wang, Hao Wang, Lan Guo, Guang Chen, Rong-Mei Kong, Fengli Qu and Lian Xia Abstract Although the potential of gold amalgam as nanoenzyme has been demonstrated, their practical utility has been limited by low catalytic activity caused by aggregation of Au nanoparticles (Au NPs).
Disrupted hippocampal growth hormone secretagogue receptor 1α interaction with dopamine receptor D1 plays a role in Alzheimer′s disease
Research ArticleAlzheimer’s Disease Jing Tian1,*, Lan Guo1,*, Shaomei Sui1,2, Christopher Driskill3, Aarron Phensy3, Qi Wang1,2, Esha Gauba1, Jeffrey M. Zigman4, Russell H. Swerdlow5, Sven Kroener3 and Heng Du1,† 1Department of Biological Sciences, University of Texas at Dallas, Richardson, TX 75080, USA. 2Department of Neurology, Qianfoshan Hospital, Shandong First Medical University, Jinan, Shandong 250014, China.
Choice-Selective Neurons in the Auditory Cortex and in Its Striatal Target Encode Reward Expectation
Research Articles, Systems/Circuits Lan Guo, Jardon T. Weems, William I. Walker, Anastasia Levichev and Santiago Jaramillo Journal of Neuroscience 8 May 2019, 39 (19) 3687-3697; DOI: https://doi.org/10.1523/JNEUROSCI.2585-18.2019 Abstract Learned behavioral responses to sounds depend largely on the expected outcomes associated with each potential choice.
Sexual minority status and suicidal behaviour among Chinese adolescents: a nationally representative cross-sectional study
As the largest low/middle-income country with a high suicide rate, China accounts for 21% of the world’s population and 30%–40% of the world’s suicides. 9 Although numerous studies have focused on suicide risk in Chinese adolescents, 10 11 little attention has been devoted to sexual minorities.
Stable representation of sounds in the posterior striatum during flexible auditory decisions
The striatum is comprised of two main neuronal outputs, the direct (or striatonigral) pathway and the indirect (or striatopallidal) pathway. One experimentally supported model of dorsal striatal function posits that the striatal direct pathway promotes action initiation11,12.
Associations of Childhood Maltreatment with Single and Multiple Suicide Attempts among Older Chinese Adolescents
Publication HistoryPublished online: March 09, 2018Accepted: January 11, 2018; Received in revised form: November 28, 2017; Received: May 20, 2017;
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