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Lanfen Chen

As seen in: Nature, Wiley Online Library, Royal Society of Chemistry, Cell Press, Cell Reports Medicine
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Articles by Lanfen Chen

Small interfering RNA-mediated silencing of mutant NPM1 suppresses acute myeloid leukemia via reversing KAT7 and p300-mediated histone acetylation

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By Yongqiang Hou, Yunzhi Xing, Chunjie Chen, Dongxue Su, Zhien Zhou, Yi Ye, Zhangjian Lai, Zhixian Peng, Min Sun, Yue Liu, Haitao Huang, Zhe Li, Jinhuan Li, Junhong Li, Huan Gao, Jiaxin Li, Hao Zhao, Yiran Shi, Qinghua Chen, Jun Long, Jiong Hu, Dawang Zhou, Lanfen Chen, Hongxi Cai, Bingying Yang
| Nature Verified
Abstract NPM1 mutation (NPM1c)-driven acute myeloid leukemia (AML) is characterized by the sequestration of nuclear proteins and chromatin hijacking. Current treatment strategies targeting NPM1c AML are often indirect, which might lead to toxicity and resistance. In this study, we developed an allele-specific siRNA that selectively silences NPM1c while preserving the function of wild-type NPM1.
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Author Correction: The transcriptional coactivator TAZ regulates reciprocal differentiation of T H 17 cells and T reg cells

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By Jing Geng, Shujuan Yu, Hao Zhao, Xiufeng Sun, Xun Li, Ping Wang, Xiaolin Xiong, Lixin Hong, Changchuan Xie, Jiahui Gao, Yiran Shi, Jiaqi Peng, Randy Johnson, Nengming Xiao, Linrong Lu, Jiahuai Han, Dawang Zhou, Lanfen Chen
| Nature Verified
Correction to: Nature Immunology https://www.nature.com/articles/ni.3748, published online 15 May 2017. Following publication of this article, the authors identified an error in Supplementary Fig. 1b. The flow cytometry plot of spleen from Mst1/2 DKO mice was inadvertently duplicated with the panel for wild-type lymph node samples due to a copy-paste error during the assembly of the figure. We have retrieved the original raw FACS data and provided the corrected Supplementary Fig. 1b.
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Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2

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By Shihao Zhang, Qinghua Chen, Qingxu Liu, Yuxi Li, Xiufeng Sun, Lixin Hong, Chengyan Liu, Jing Geng, Weiji Zhang, Zhonglei Lu, Zhen-Yu Yin, Yuanyuan Zeng, Kwang-Huei Lin, Qiao Wu, Qiyuan Li, Keiko Nakayama, Keiich I. Nakayama, Xianming Deng, Randy Johnson, Liang Zhu, Daming Gao, Lanfen Chen, Dawang Zhou, Suyuan Ji
| Cell Press Verified
Main text (Cancer Cell 31, 669–684.e1-e7; May 8, 2017) We, the authors of this publication, demonstrated that Yap promotes polyploidy and oncogenesis by driving Akt-dependent acetylation of Skp2, which stabilizes p27 to induce mitotic arrest while degrading FoxO1/3 to enable genomic instability and tumor formation. We have recently become aware of errors in Figure 5D and Figure S2C.
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Inhibiting NEDD4 in triple-negative breast cancer cells reprograms tumor immune microenvironment via the β-TrCP/YAP/ECM axis

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By Nan Su, Wenhua Lian, Baoding Zhang, Yuan Tian, Linying Li, Yiyu Chen, Xiang Zhi, Taoling Zeng, Qiao Wu, Lanfen Chen, Dawang Zhou, Hong-Rui Wang, Shih-Chin Cheng, Xianming Deng
| Cell Reports Medicine Verified
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The p75 neurotrophin receptor controls the skeletal stem cell niche through sensory innervation

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By Zuoxing Wu, Zhengqiong Luo, Zihan Chen, Xuemei He, Fan Shi, Jie Han, Haitao Huang, Baohong Shi, Long Zhang, Yu Li, Junmin Shen, Seoyeon Bok, Jun Sun, Xing Niu, Ke Mo, Pengbin Yin, Lige Leng, Xin Wang, Jie Zhang, Lanfen Chen, Dawang Zhou, Weinan Cheng, Jianmin Huang, Matthew Greenblatt, Ren Xu
| Cell Press Verified
Keywords skeletal stem cell niche osteogenesis innervation p75NTR Alzheimer’s disease Get full text access Log in, subscribe or purchase for full access. References 1. Bliuc, D. ∙ Tran, T. ∙ Adachi, J.D. ... Cognitive decline is associated with an accelerated rate of bone loss and increased fracture risk in women: a prospective study from the Canadian Multicentre Osteoporosis Study J. Bone Miner. Res. 2021; 36:2106-2115 2. Ruggiero, C. ∙ Baroni, M. ∙ Xenos, D. ...
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Headache: The Journal of Head and Face Pain | AHS Journal | Wiley Online Library

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By Mengqi Zhao, Lanfen Chen, Zhixiang Cheng, Xizhen Wang
| Wiley Online Library Verified
CONFLICT OF INTEREST STATEMENT Mengqi Zhao, Lanfen Chen, Zhixiang Cheng, Xizhen Wang, Shuxian Zhang, Mengting Li, Zeqi Hao, Xihe Sun, Jianxin Zhang, Yang Yu, Jun Ren, and Xize Jia declare no conflicts of interest. Supporting Information Filename Description head14900-sup-0001-supinfo.docxWord 2007 document , 290.3 KB Data S1. REFERENCES 1, , , et al. Tension-type headache. Nat Rev Dis Prim. 2021; 7: 24. 2, , , et al.
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Bifunctional monomer oligomers-based composite molecularly imprinted membranes for the electrochemical monitoring of Sudan I

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By Qin Gao, Yang Zang, Ju Xie, Lanfen Chen
| Royal Society of Chemistry Verified
Bifunctional monomer oligomers-based composite molecularly imprinted membranes for the electrochemical monitoring of Sudan I Qin Gao, Yang Zang, Ju Xie, Lanfen Chen, Jiaqi Xu, Hao Huang and Huaiguo Xue Abstract Herein, we developed a highly sensitive electrochemical sensor for the trace detection of Sudan I (SDI) dye based on composite molecularly imprinted membranes (MIMs).
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