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Articles by Lars Lind
The plasma protein profile of left ventricular diastolic function
Abstract We aimed to characterize associations between plasma proteins and indices of left ventricular (LV) diastolic function in two population-based studies. Eighty-six cardiovascular-related plasma proteins measured by proximity extension assay (PEA) and echocardiography were assessed in the population-based studies PIVUS (n = 1,016; all aged 70) and POEM (n = 502; all aged 50).
Integrating social and cardiometabolic risk factors in predicting cardiometabolic multimorbidity: a Bayesian model development and internal validation in Swedish middle-aged adults
Abstract Cardiometabolic diseases often cluster as multimorbidity, yet current risk prediction models typically focus on a single disease and rarely incorporate social determinants. This study aims to develop a Bayesian risk prediction model for cardiometabolic multimorbidity in middle-aged Swedish adults. This prospective cohort included 11,964 adults without prior cardiometabolic disease from the Swedish CArdioPulmonary bioImage Study (SCAPIS; enrolment 2013–2016).
Plasma neuropilin-1 is associated with a favorable lipid profile and insulin sensitivity in a population-based sample of 50-year-old individuals
Abstract Membrane-bound neuropilin-1 (Nrp-1) has been implicated as a regulator of insulin resistance-related lipid metabolism, but little is known about its circulating form, soluble Nrp-1 (sNrp-1), in a metabolic context. Here we investigated the association between plasma levels of sNrp-1 and metabolic variables in 501 participants from the Prospective investigation of Obesity, Energy and Metabolism (POEM) study.
Antibiotic use and gut microbiome composition links from individual-level prescription data of 14,979 individuals
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Abstract Disruptions in gut microbiome are implicated in cardiometabolic disorders and other health outcomes. Antibiotics are known gut microbiome disruptors, but their long-term consequences remain underexplored. Here we combined individual-level data from the Swedish Prescribed Drug Register with fecal metagenomes of 14,979 adults to examine the association between oral antibiotic use over 8 years and gut microbiome.
By Gabriel Baldanzi, Anna Larsson, Sergi Sayols-Baixeras, Koen F. Dekkers, Ulf Hammar, Diem Nguyen, Tiscar Graells, Shafqat Ahmad, Camila Gazolla Volpiano, Guillaume Meric, Josef D. Järhult, Thomas Tängdén, Jonas Ludvigsson, Lars Lind, Johan Sundström, Karl Michaëlsson, Johan Ärnlöv, Beatrice Kennedy, Marju Orho-Melander, Tove Fall
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Nature
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Effects of an anti-lipogenic low-carbohydrate high polyunsaturated fat diet or a healthy Nordic diet versus usual care on liver fat and cardiometabolic disorders in type 2 diabetes or prediabetes: a randomized controlled trial (NAFLDiet)
Abstract Polyunsaturated fatty acids (PUFA) have been shown to reduce liver fat compared to saturated fat, but effects of a novel “anti-lipogenic” diet replacing carbohydrates with PUFA (LCPUFA) or a low-fat healthy Nordic diet (HND) rich in whole-grains are unknown.
Risk differences and underlying factors of cardiovascular events and mortality in patients with type 2 diabetes versus type 1 diabetes: a longitudinal cohort study of Swedish nationwide register data
aDepartment of Medical Sciences, Clinical Diabetology and Metabolism, Uppsala University, Uppsala, Sweden bUnit of Clinical Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden cDepartment of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden dSahlgrenska University Hospital and Department of Molecular & Clinical Medicine, University of Gothenburg, Gothenburg, Sweden eSwedish National Diabetes Register, Cetnter of Registers, Gothenburg, Sweden...
Cardiopulmonary exercise testing and body composition
Introduction The cardiopulmonary exercise test (CPET) is a diagnostic instrument commonly employed in clinical settings to evaluate an individual's health status. It provides insight into an individual's gas exchange during exercise, aiding in the assessment of their overall physiological status [1].
JCM | Free Full-Text | The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Increased Glomerular Production or Permeability in Diabetes Mellitus?
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
An association between heart rate variability and incident heart failure in an elderly cohort
1 INTRODUCTION Heart failure (HF) has a prevalence of 1%–2% in the general population, increasing to over 10% in individuals aged ≥70 years1 and is expected to increase because of the steadily increasing age of the population.2 Although substantial progress has been made in diagnosing and managing HF, the prognosis is still poor.1 The current definition of HF requires manifest clinical symptoms due to structural or functional cardiac abnormalities.3 Early detection of individuals at high risk...
The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Glomerular Function and Activity in Diabetes Mellitus
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 15 February 2024 / Approved: 15 February 2024 / Online: 16 February 2024 (11:34:01 CET) Xu, S.; Larsson, A.; Lind, L.; Lindskog, C.; Ärnlöv, J.; Venge, P. The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Glomerular Function and Activity in Diabetes Mellitus. Preprints 2024, 2024020905.
A comparison of intima media thickness in the common carotid artery, the bulb and plaque area as predictions of incident atherosclerotic events
Loading metrics Open Access Peer-reviewed Research Article Citation: Lind L (2023) A comparison of intima media thickness in the common carotid artery, the bulb and plaque area as predictions of incident atherosclerotic events. PLoS ONE 18(11): e0294722. https://doi.org/10.1371/journal.pone.0294722 Editor: Yasunori Sato, Keio University School of Medicine, JAPAN Received: May 2, 2023; Accepted: November 6, 2023; Published: November 20, 2023 Copyright: © 2023 Lars Lind.
Heterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs
Heterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs: A Randomized Clinical Trial Key Points Question Is there a potential for personalized drug therapy in hypertension, and, if so, what is the magnitude of the benefit of personalization? Findings In this randomized, double-blind, repeated crossover trial, the blood pressure response to treatments varied substantially between individuals.
The metabolic profile of waist to hip ratio-A multi-cohort study
PLOS ONE, Feb 2023 This is a preview of a remote PDF: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0282433&type=printable Lars Lind, Shafqat Ahmad, Sölve Elmståhl, Tove Fall. , PLOS ONE, 2023, Volume 18, Issue 2, DOI: 10.1371/journal.pone.0282433
Skrota myten om metabolt ofarlig fetma
En debatt har pågått mellan författarna till boken »Kriget mot kroppen« och ett flertal forskare avseende hälsorisker med obesitas [1-3]. En del i debatten innefattar begreppet »metabolt ofarlig fetma«. För cirka 15 år sedan föreslogs det att de cirka 20–25 procent av befolkningen med BMI >30 m/kg2 som inte uppvisar det så kallade metabola syndromet (det vill säga rubbningar i blodfetter och glukosmetabolismen samt högt blodtryck) inte behöver drabbas av oönskade hälsoeffekter.
The metabolic profile of waist to hip ratio-A multi-cohort study
Metabolomics In all three study samples, metabolomics (Metabolon inc., USA) was performed on plasma samples being stored at -80°C. 100μl of human plasma was utilized for analysis. 500μl of methanol was added to each sample. Samples were prepared using the automated MicroLab STAR® system from Hamilton Company. Several internal standards were added prior to the first step in the extraction process for QC purposes.
The metabolomic profile associated with clustering of cardiovascular risk factors-A multi-sample evaluation
Statistics All metabolomic data were subjected to inverse rank normalization within each sample. One linear regression model for each metabolite was performed vs the five MetS components separately (systolic blood pressure (SBP), fasting glucose (GLU), triglycerides (TG), HDL-cholesterol (HDL) and waist circumference (WC)). All of these analyses were adjusted for age, sex and BMI, as well as for the life-style factors alcohol intake, smoking habits, exercise habits and education level.
‘MultiVersus’ Review — Culture Slate
Another competitor in the arcade-style fighting genre stepped into the ring this week. One of the most anticipated releases of 2022, MultiVersus, gives us a new take on mainstream pop culture figures beating each other to a pulp. Developed by Player First Games and published by Warner Brothers (WB), MultiVersus is a free-to-play crossover fighting game that provides players plenty of fun. However, the game is certainly not without its downfalls.
Marvel and Disney Announce A Games Showcase During D23 This September — Culture Slate
As if there wasn’t enough reason to be excited for D23, Disney just announced they will be adding a Disney and Marvel Games Showcase to their biggest event of the year. On Friday, September 9th, at 1 p.m. PT/4 p.m. ET we will be shown a cavalcade of new content; Disney & Pixar Games, Marvel Games, Lucasfilm Games, and 20th Century games have all been confirmed to be a part of this exhibition.
How ‘Obi-Wan Kenobi’ Could Tie Into ‘Jedi: Survivor’ — Culture Slate
Jedi: Survivor will be the most anticipated Star Wars game since Electronic Art’s Battlefront (2015). With the proven success of its predecessor, there should be little to no apprehension over the quality of the game. At this point, there is no reason we should expect anything less than the excellent gameplay and story that Jedi: Fallen Order delivered. On May 27th, Electronic Arts (EA) revealed the first trailer for Jedi: Survivor, the sequel to the critically acclaimed Jedi: Fallen Order.
Most Anticipated Games Left In 2022 — Culture Slate
2022 will go down as a historic year in video games once it is all said and done. We are entering Q4 of this monumental year with more than a few blockbuster titles left on the slate. You won’t find many people arguing with the idea of Elden Ring winning Game of the Year. It very well might take that title. But a few of these games will not make that decision easy. Last Of Us Part I - September 2nd - (PS5/PC) What is a Last of Us game without its controversy? Warranted or not.
6 Video Games That Make You Feel Like A Jedi — Culture Slate
If I were ever faced with a Robin Williams-style Genie, there is no doubt in my mind that I would spend one of those wishes on becoming a Jedi. Sorry, world peace. Pushing stuff around with my mind comes first. You might not be as passionate about sacrificing world peace to be a space wizard as I am, but chances are you have dreamed about wielding a lightsaber of your own.
A comparison of echocardiographic and circulating cardiac biomarkers for predicting incident cardiovascular disease
Echocardiography assessments A comprehensive two-dimensional and Doppler echocardiography was performed with an Acuson XP124 cardiac ultrasound unit (Acuson, California, USA) using a 2.5 MHz transducer. All echocardiography measurements were performed by the same experienced clinician (L.L.) and were evaluated in real-time. Reproducibility data was not available. Left ventricular dimensions were measured with M-mode on-line from the parasternal view, using a leading-edge-to-leading-edge method.
Key Characteristics of Cardiovascular Toxicants
About Article Metrics Publication History Manuscript received15 March 2021 Manuscript revised25 August 2021 Manuscript accepted27 August 2021 Originally published24 September 2021 License information EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.
Seasonal variations in sleep duration and sleep complaints: A Swedish cohort study in middle‐aged and older individuals
Summary Subjective sleep reports are widely used research tools in epidemiology. Whether sleep reports can differ between seasons is less clear.
Sleep duration is associated with protein biomarkers for cardiometabolic health: A large‐scale population study
Abstract Sleep problems and short sleep duration have been linked to adverse health effects, such as cardiovascular disease and diabetes, but the mechanisms are not fully understood. Finding biomarkers could explain mechanistic pathways and help in understanding relationships between sleep and cardiometabolic health. The aim was to assess if sleep duration and sleep quality affect the cardiometabolic‐related protein profile.
The Precision HYpertenSIon Care (PHYSIC) study: a double-blind, randomized, repeated cross-over study
Background High blood pressure is the leading risk factor for premature deaths worldwide (1) and accounts for more than 10% of all health care costs in some developed countries, with a mere fifth of that attributable to medication costs, and four-fifths to complications (2). Less than half of those who have high blood pressure are aware of it, and, of those receiving blood pressure-lowering drug treatment, only one-third have their blood pressure at target levels (3).
Effect of new statin treatment on carotid artery intima-media thickness: A real-life observational study over 10 years
Highlights • The real-life effect of new statin treatment on carotid intima-media thickness (IMT) was investigated over 10 years. • A longitudinal cohort study was used. • The statin naïve group had a higher increase in IMT over the 10 years than the group receiving statins. • This real-life study showed new statin treatment to reduce the increase in IMT observed over 10 years.
Urinary bisphenol A and serum lipids: a meta-analysis of six NHANES examination cycles (2003-2014)
Urinary bisphenol A and serum lipids: a meta-analysis of six NHANES examination cycles (2003–2014) Linda Dunder1, Margareta H Lejonklou1, P Monica Lind1, Lars Lind2 1 Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden 2 Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden Correspondence to Linda Dunder, Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala...
Physical activity is associated with a large number of cardiovascular-specific proteins: Cross-sectional analyses in two independent cohorts
1. Cornelissen, VA, Smart, NA. Exercise training for blood pressure: A systematic review and meta-analysis. J Am Heart Assoc 2013; 2: e004473. Google Scholar | Crossref | Medline | ISI 2. Manson, JE, Nathan, DM, Krolewski, AS, et al. A prospective study of exercise and incidence of diabetes among US male physicians. JAMA 1992; 268: 63–67. Google Scholar | Crossref | Medline | ISI 3. Halbert, JA, Silagy, CA, Finucane, P, et al.
Longitudinal effects of aging on plasma proteins levels in older adults - associations with kidney function and hemoglobin levels
Loading metrics Open Access Peer-reviewed Research Article Lars Lind , Johan Sundström, Anders Larsson, Erik Lampa, Johan Ärnlöv, Erik Ingelsson Lars Lind, Johan Sundström, Anders Larsson, Erik Lampa, Johan Ärnlöv, Erik Ingelsson Published: February 25, 2019 https://doi.org/10.1371/journal.pone.0212060 Figures Abstract Background A targeted proteomics chip has been shown to be useful to discover novel associations of proteins with cardiovascular disease.
Predictors of 10-year changes in levels of N-terminal pro B-type natriuretic peptide and cardiac troponin I in the elderly
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. FiguresFig. 1Association between NT-proBNP levels over 10?years and the change in cTnI levels. The graph shows NT-proBNP levels in relation to the 25th, 50th and 75th percentile of the change in cTnI levels.
Neurotoxic chemicals in adipose tissue
Midlife obesity is associated with increased risk of dementia, whereas late-life obesity is commonly associated with a lower risk of dementia. Although methodologic issues are often discussed in this apparent risk reversal, chronic exposure to low-dose organochlorine pesticides (OCPs), an emerging risk factor for dementia in general populations, may contribute to a direct explanation for these differences.
Discovery of new biomarkers for atrial fibrillation using a custom-made proteomics chip
Background Apart from several established clinical risk factors for atrial fibrillation (AF), a number of biomarkers have also been identified as potential risk factors for AF. None of these have so far been adopted in clinical practice. Objective To use a novel custom-made proteomics chip to discover new prognostic biomarkers for AF risk.
Population attributable risks and costs of diabetogenic chemical exposures in the elderly
PIVUS is a population-based cohort derived from the individuals aged 70 living in the city of Uppsala, Sweden (n=1016; 50% women). For full details, please see Lind et al. 10 Prevalent diabetes was defined as antidiabetic therapy or fasting plasma glucose ?7.0?mmol/L (n=119). Fasting blood was drawn in the morning for the determination of 33 environmental contaminants.
Population attributable risks and costs of diabetogenic chemical exposures in the elderly
Background A previous analysis examined the contribution of endocrine disruptor exposures (endocrine-disrupting chemicals, EDCs) to adult diabetes, but was limited to effects of phthalates in middle-aged women and did not simultaneously examine multiple EDCs which are known to coexist in the environment. We therefore endeavoured to quantify potential reductions in diabetes and disease costs that could result from reducing synthetic chemical diabetogenic exposures in the elderly in Europe.
Population attributable risks and costs of diabetogenic chemical exposures in the elderly
Background A previous analysis examined the contribution of endocrine disruptor exposures (endocrine-disrupting chemicals, EDCs) to adult diabetes, but was limited to effects of phthalates in middle-aged women and did not simultaneously examine multiple EDCs which are known to coexist in the environment. We therefore endeavoured to quantify potential reductions in diabetes and disease costs that could result from reducing synthetic chemical diabetogenic exposures in the elderly in Europe.
Discovery of new biomarkers for atrial fibrillation using a custom-made proteomics chip
Background Apart from several established clinical risk factors for atrial fibrillation (AF), a number of biomarkers have also been identified as potential risk factors for AF. None of these have so far been adopted in clinical practice. Objective To use a novel custom-made proteomics chip to discover new prognostic biomarkers for AF risk.
Skuggans lag : en spanares kamp mot prostitutionen
Kriminalinspektör Simon Häggström är chef för prostitutionsgruppen: en enhet inom Stockholmspolisen. I sin vardag möter han alla de som samhället inte vill se: de prostituerade som gör sitt bästa för att sköta sina affärer utom synhĺll och torskarna som till varje pris vill undvika upptäckt och straff. Trots att Sverige ligger relativt lĺngt fram i bekämpningen av prostitution lever verksamheten och frodas.
Discovery of New Risk Markers for Ischemic Stroke Using a Novel Targeted Proteomics Chip
Background and Purpose—Emerging technologies have made it possible to simultaneously evaluate a large number of circulating proteins as potential new stroke risk markers.
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