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Laurent Debarbieux on Muck Rack

Laurent Debarbieux

As seen in: Nature, PLOS, MDPI, Science Magazine, BioRxiv, Cell Host & Microbe, Cell Press, Cell Reports
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Articles

Bacteriophage PAK_P3 genome structuration and dynamics during infection of Pseudomonas aeruginosa reveal specific interaction patterns

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By Mads Peter Heide-Jørgensen, Fangbing Chen, Jeric Da-Anoy, Amaury Bignaud, Quentin Lamy-Besnier, Agnès Thierry, Fabien Girard, Pauline Misson, Romain Koszul, Laurent Debarbieux, Martial Marbouty, Devon E. Conti
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract While the dynamic changes in genome organization in cellular organisms have been well described, the three-dimensional (3D) folding of phage genomes during the infection of their host is extremely limited.
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Phages with a broad host range are common across ecosystems - Nature Microbiology

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By Amaury Bignaud, Jacques Serizay, Karine Labadie, Maritrini Colón-González, Laurent Debarbieux, Sophie Helaine, Lucía Morales, Andrés Parada, Nadia Riera, Gregorio Iraola, Romain Koszul
| Nature Verified
Abstract Phages are diverse and abundant within microbial communities, where they play major roles in their evolution and adaptation. Phage replication, and multiplication, is generally thought to be restricted within a single or narrow host range. Here we use published and newly generated proximity-ligation-based metagenomic Hi-C (metaHiC) data from various environments to explore virus–host interactions. We reconstructed 4,975 microbial and 6,572 phage genomes of medium quality or higher.
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Characterization of an amyloid-based antiphage defence system in Escherichia coli - Nature Microbiology

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By Nicolas Dufour, Laurent Debarbieux, Brice Kauffmann, Antoine Loquet
| Nature Verified
Abstract Amyloids are β-sheet-rich protein polymers that can cause disease but also serve functional purposes in cells. In animals and fungi, functional amyloids have a role in regulated cell death as molecular switches activating key cell death effectors. Here we describe an amyloid-based abortive infection antiphage defence system in Escherichia coli.
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