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Laurent Debarbieux on Muck Rack

Laurent Debarbieux

As seen in: Nature, PLOS, MDPI, BioRxiv, Cell Reports, Cell Host & Microbe, Cell Press
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Articles

Phages with a broad host range are common across ecosystems - Nature Microbiology

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By Amaury Bignaud, Jacques Serizay, Karine Labadie, Maritrini Colón-González, Laurent Debarbieux, Sophie Helaine, Lucía Morales, Andrés Parada, Nadia Riera, Gregorio Iraola, Romain Koszul
| Nature Verified
Abstract Phages are diverse and abundant within microbial communities, where they play major roles in their evolution and adaptation. Phage replication, and multiplication, is generally thought to be restricted within a single or narrow host range. Here we use published and newly generated proximity-ligation-based metagenomic Hi-C (metaHiC) data from various environments to explore virus–host interactions. We reconstructed 4,975 microbial and 6,572 phage genomes of medium quality or higher.
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Characterization of an amyloid-based antiphage defence system in Escherichia coli - Nature Microbiology

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By Nicolas Dufour, Laurent Debarbieux, Brice Kauffmann, Antoine Loquet
| Nature Verified
Abstract Amyloids are β-sheet-rich protein polymers that can cause disease but also serve functional purposes in cells. In animals and fungi, functional amyloids have a role in regulated cell death as molecular switches activating key cell death effectors. Here we describe an amyloid-based abortive infection antiphage defence system in Escherichia coli.
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Adjunctive phage therapy improves antibiotic treatment of ventilator-associated-pneumonia with Pseudomonas aeruginosa - Nature Communications

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By Baptiste Gaborieau, Laurent Debarbieux, Jean-Damien Ricard, Chantal Weissfuss, Magdalena Bürkle
| Nature Verified
Abstract Bacterial multidrug resistance poses an urgent challenge for the treatment of critically ill patients developing ventilator-associated pneumonia (VAP). Phage therapy, a potential alternative when conventional antibiotics fail, has been unsuccessful in first clinical trials when used alone. Whether combining antibiotics with phages may enhance effectiveness remains to be tested in experimental models.
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