Leona Rusling

ArticleVolume 6, Issue 12102478Open access 1Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 2Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 3Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 4Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Publication History: Received October 23, 2023; Revised...

Abstract RNA modifications are essential for the regulation of cellular processes and have a key role in diseases such as cancer and neurological disorders. A major challenge in the analysis of RNA modification is the differentiation between isomers, including methylated nucleosides as well as uridine and pseudouridine. A solution is their differential chemical reactivity which enables isomer discrimination by mass spectrometry (MS) or sequencing.