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Lingyin Li on Muck Rack

Lingyin Li

As seen in: Nature, Cell Reports, Cell Reports Medicine, Cell Press, The Journal of Biological Chemistry
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Articles

Activation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling

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By Valentino Sudaryo, Dayanne R. Carvalho, Jacqueline Carozza, Xujun Cao, Courtney Kernick, Anthony Cordova, J. Lee, Theodore L. Roth, Lingyin Li
| Cell Reports Verified
Keywords STING cGAMP extracellular cGAMP ADU-S100 arginine toxicity T cells SLC7A1 LRRC8A LRRC8C VRAC Research topic(s) CP: immunology CP: molecular biology Introduction A hallmark of cancer is the presence of aberrantly packaged double-stranded DNA (dsDNA) in the cytosol, resulting from chromosomal instability, damaged mitochondria, extrachromosomal DNA replication, or treatment-induced chromatin bridges.1,2,3,4 The innate immune pattern recognition receptor cGAS, upon recognizing cytosolic...
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ENPP1 inhibitor with ultralong drug-target residence time as an innate immune checkpoint blockade cancer therapy

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By Songnan Wang, Randolph Johnson, Jacqueline Carozza, DANIEL FERNANDEZ, Rachel E. Mardjuki, Xujun Cao, Yingjie Guo, Nigel Ray, Lingyin Li, Jan Scicinski, Neil A. Verity, Jacqueline Papkoff
| Cell Reports Medicine Verified
Keywords STING agonist immunotransmitter breast cancer colorectal cancer pancreatic cancer glioblastoma Introduction Despite the advancement in early detection and treatment, currently more than 18 million Americans are affected by cancer.1 Adaptative immune checkpoint inhibitors (ICIs) unleash tumor-infiltrating lymphocytes (TILs) to fight cancer, offering cures to patients who have exhausted other treatment options.
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PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity - Nature

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By Wei Wei, Xuchao Lyu, Peter Cavanagh, Shuke Xiao, Meng Zhao, Steven Truong, Lianna W. Wat, Duo Xu, Cholsoon Jang, Lingyin Li, Katrin J. Svensson
| Nature Verified
Abstract Taurine is a conditionally essential micronutrient and one of the most abundant amino acids in humans1,2,3. In endogenous taurine metabolism, dedicated enzymes are involved in the biosynthesis of taurine from cysteine and in the downstream metabolism of secondary taurine metabolites4,5. One taurine metabolite is N-acetyltaurine6.
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