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Liron Bar-Peled

As seen in: Nature, PNAS, Science Magazine, Cell Press
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Articles

Bridging oxidative post-translational modifications to biological meaning

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By Maolin Ge, Magdy Gohar, Liron Bar-Peled, Junbing Zhang
| Cell Press Verified
Keywords oxiPTMs fold change stoichiometry redox proteomics functional genomics Get full text access Log in, subscribe or purchase for full access. References 1. Xiao, H. ... A quantitative tissue-specific landscape of protein redox regulation during aging Cell. 2020; 180:968-983.e24 2. Zhang, J. ... Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway Cell. 2023; 186:2361-2379.e25 3. Zhang, J. ...
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EGFR inhibitor-resistant lung cancers exhibit collateral sensitivity to a covalent, cysteine-independent KEAP1 oligomerizing molecular bridge - Nature Communications

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By Jacob P. Hoj, Christian Cerda-Smith, Haley Hutchinson, Shane T. Killarney, Li Qin, Guillaume Robert Verified, Liron Bar-Peled, David M Lonard, Anthony Martin, Alexandre Puissant, Christopher F. Bassil
| Nature Verified
Abstract Targeted therapies have revolutionized cancer care. Unfortunately, most patients develop refractory, multifocal resistance to these therapies within a matter of months. Here, we demonstrate that the evolution of resistance to EGFR inhibitors in EGFR-mutant non-small cell lung cancer endows cells with hypersensitivity to a PAINS-like small molecule, MCB-613.
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UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors - Nature

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By Olivia Zhang, Xiaowen Xie, N. Connor Payne, Pallavi M. Gosavi, Hui Si Kwok, Ceejay Lee, Nicholas Chen, Hanjie Jiang, Zhipeng Wang, Kwangwoon Lee, Amanda Waterbury, Marco Barone, Andrea Mattevi, Steven Carr, Namrata D. Udeshi, Liron Bar-Peled, Philip Cole, Ralph Mazitschek, Brian B. Liau, Irtiza Iram
| Nature Verified
Abstract UM171 is a potent agonist of ex vivo human haematopoietic stem cell self-renewal1. By co-opting KBTBD4, a substrate receptor of the CUL3–RING E3 ubiquitin ligase (CRL3) complex, UM171 promotes the degradation of the LSD1–CoREST corepressor complex, thereby limiting haematopoietic stem cell attrition2,3. However, the direct target and mechanism of action of UM171 remain unclear.
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