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Articles by Lu Pan
Correction: The association between AI literacy and creative self-efficacy: a moderated mediation model of learning adaptability and teacher support
A Correction on The association between AI literacy and creative self-efficacy: a moderated mediation model of learning adaptability and teacher support by Pan, L., Shuang, X., and Liu, Y. (2026). Front. Psychol. 17:1798750. doi: 10.3389/fpsyg.2026.1798750 An incorrect in-text citation was included in section 4 Discussion, paragraph 2. Yu et al.
Depression and anxiety mediate the association between sleep quality and health-related quality of life in people living with HIV
Abstract Sleep disturbances are highly prevalent among people living with HIV (PWH) and frequently co-occur with psychiatric comorbidities such as depression and anxiety. Although these factors independently predict health-related quality of life (HRQoL), the extent to which psychiatric symptoms explain the relationship between sleep quality and HRQoL—particularly within the Chinese context—remains unclear. Understanding these pathways is critical for optimizing holistic HIV care.
Protein Biomarkers in Risk and Prognosis of Amyotrophic Lateral Sclerosis
1 Introduction Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive loss of upper and lower motor neurons, leading to muscle weakness, paralysis, and respiratory failure. The global incidence of ALS is approximately 1.59 per 100,000 person-years, with a prevalence of 4.42 per 100,000 individuals [1]. A higher incidence rate is observed in Europe, ranging from 2.1 to 3.8 per 100,000 person-years [2].
A hybrid high activity aware framework integrating graph attention network and transformer for half maximal inhibitory concentration prediction
Abstract Introduction: Tyrosine kinase inhibitors targeting the c-KIT receptor are pivotal in the targeted therapy of malignancies such as gastrointestinal stromal tumors (GIST). The bioactivity of these inhibitors is typically quantified by the half-maximal inhibitory concentration (IC50), making its accurate prediction a critical computational task for accelerating the discovery and optimization of anticancer lead compounds.
Lymphocyte activation gene 3 in autoimmune disease: from molecular mechanisms to clinical applications
Abstract Lymphocyte activation gene 3 (LAG3) has become an important immune checkpoint receptor, which plays a crucial role in regulating the immune response. The immunoregulatory function of LAG3 is achieved through complex receptor-ligand interactions, structure-function relationships, and unique signaling pathways. The role of LAG3 in cancers has been widely explored, and drugs targeting LAG3 are constantly emerging, demonstrating promising application prospects.
Comparison of positive detection rates between fluorescent staining and traditional KOH wet mount methods in the diagnosis of superficial fungal skin infections and analysis of factors associated with missed diagnosis
Abstract Background: Superficial fungal skin infections represent one of the most prevalent dermatological conditions worldwide, necessitating accurate and rapid laboratory diagnosis for appropriate therapeutic management. Objective: This retrospective study aimed to compare the positive detection rates between fluorescent staining and traditional KOH wet mount methods in patients with clinically suspected superficial fungal infections and to identify factors associated with missed diagnosis.
The chemistry of habitable oceans in the Solar system
Abstract Liquid water exists on the Earth and several other planetary bodies in our solar system. The chemical character of these aqueous reservoirs is central to evaluating their habitability. Here, we synthesize the chemical features of water reservoirs and their biological implications on the modern Earth. We then outline constraints on the evolutionary history of Earth’s ocean chemistry and discuss its interplay with the biosphere.
C/EBP alpha agonist ICCB280 overcomes doxorubicin resistance in osteosarcoma through mitochondrial dynamics-dependent GREM1-MAPK activation
Abstract The resistance of doxorubicin (DOX), the first-line chemotherapeutic drug for osteosarcoma (OS), stands as a pivotal obstacle in the effective treatment of OS. Alterations in mitochondrial dynamics and thereby affecting reactive oxygen species (ROS) accumulation play critical roles in DOX-induced cell death. However, the novel targets and pharmacological agents combating DOX resistance in OS via mitochondrial homeostasis and DOX-induced cell death manipulation is poorly understood.
Single-cell profiling reveals distinct populations of tumor-associated macrophages and metastatic tumor cells in breast cancer brain metastasis
Abstract Breast cancer brain metastasis (BCBM) is a major cause of breast cancer-related mortality, but the molecular mechanisms underlying its progression remain poorly understood. Here, we profiled the tumor immune microenvironment of BCBM at single-cell resolution and identified candidate regulators associated with brain metastatic progression.
Molecular Mechanisms and Efficacy of Tislelizumab, a PD‐1 Inhibitor Developed in China, in Non‐Small Cell Lung Cancer
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The original contributions presented in the study are included in the article and its . Further inquiries can be directed to the first author or the corresponding author. Supporting Information Filename Description cbdd70252-sup-0001-FigureS1.tifTIFF image, 29.6 MB Figure S1: Risk of bias assessment. (A) Risk of bias graph; (B) Risk of bias summary.
Near-surface liquid water on Mars inferred from seasonal marsquakes - Nature Communications
Abstract Exploring the presence and behavior of water on Mars is critical for understanding the planet’s geological evolution, hydrological processes, and potential habitability, which has been a central objective of past and ongoing Martian exploration missions. Martian geomorphology provides evidence of ancient groundwater activity, but confirmation of present-day liquid water remains limited.
The total synthesis of (−)-spiroaspertrione A: A divinylcyclopropane rearrangement approach
Editor’s summary Spiroaspertrione A is a complex, polycyclic fungal natural product that has garnered interest in antibiotics research. Huang et al. now report a total synthesis of the compound in its natural stereoconfiguration starting from readily available precursors. Key steps included a Diels-Alder reaction to set the compound’s characteristic spiro stereocenter, as well as a divinylcyclopropane rearrangement to establish an additional out-of-plane ring.
Redox evolutions of planetary mantle reservoirs constrained by titanium isotopes - Communications Earth & Environment
Abstract The oxygen fugacity (hereafter referred as fO2) of terrestrial planets is key in defining the outcome of planetary-scale differentiation and the planets’ potential habitability. Reconstructing the initial fO2 records in the mantle right after core formation for terrestrial planets remain challenging due to frequent secondary modifications.
Free Triiodothyronine as a Biomarker for Ventricular Arrhythmia Follow
Back to Journals » Clinical Interventions in Aging » Volume 21 Authors Deng L, Gao Y, Pan L, Wang Q , Deng Y, Wang J , Huang J, Cai D , Zhang Y, Zhu W, Bao X, You H, Cai L, Chen Q , Wei J, Wang RX, Sun L Received 22 August 2025 Accepted for publication 16 January 2026 Published 27 January 2026 Volume 2026:21 Pages 1—13 DOI https://doi.org/10.2147/CIA.S562233 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Zhi-Ying...
Gram‐scale Access to (3,11)‐Cyclotaxanes – Synthesis of 1‐Hydroxytaxuspine C
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Oxygen Vacancies and Phosphorus‐Doped P‐WO3‐x/CC Electrocatalysts Boosting Hydrogen Evolution Reaction
Conflict of Interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Supporting Information Filename Description chem202501239-sup-0001-SuppMat.docx797.4 KB Supporting information References 1, , , Nano Res. 2023, 17, 2499. 2, , , , , , , , , , Appl. Catal. B 2024, 342. 3, , , , , , , , Angew. Chem. Int. Ed. 2022, 61. 4, , , , , , , , , , Chem. Eng. J. 2022, 450. 5, , , , , , , , , Adv.
Deciphering immune predictors of immunotherapy response: A multiomics approach at the pan-cancer level
Keywords pan-cancer single cell multiomics immunotherapy Introduction The tumor microenvironment (TME) is a complex and dynamic landscape that varies across cancer types.1 Within this environment, tumor-infiltrating T cells emerge as a critical feature, exhibiting the capacity to both suppress and promote tumor growth.1,2,3 Immunotherapy, and in particular immune checkpoint blockade (ICB),4 is able to enhance cytotoxicity of T cells by inhibiting checkpoint molecules on their surface,5...
Interface Engineering of Flower‐like Co2P/WO3−x/Carbon Cloth Catalysts with Oxygen Vacancies for Efficient Oxygen Evolution Reaction
Conflict of Interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset.
Constructing Co3O4 Nanowire@NiCo2O4 Nanosheet Hierarchical Array as Electrode Material for High-Performance Supercapacitor
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Electronic Structure Modulating of W 18 O 49 Nanospheres by Niobium Doping for Efficient Hydrogen Evolution Reaction
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description chem202403043-s1-Supporting_Information.pdf869.7 KB Supplementary
The genetic landscape of neuro-related proteins in human plasma - Nature Human Behaviour
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Abstract Understanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioural traits and the disease aetiology of neuropsychiatric disorders. Here the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,000 individuals for 184 neuro-related proteins in human plasma. The analysis identified 125 cis-regulatory protein quantitative trait loci (cis-pQTL) and 164 trans-pQTL.
By Jiantao Chen, Zhijian Yang, Ranran Zhai, Xiao Feng, Ting Li, Denis Maslov, Anna N. Timoshchuk, Sebastian May-Wilson, Marisa D. Muckian, Charles Kooperberg, Robert F. Hillary, Eleanor Wheeler, Lu Pan, Shahzad Ahmad, Sarah Harris, Nicholas J Wareham, Cecilia Lagging, Mohammad Arfan Ikram, Mikael Landén, Claudia Langenberg, Ian J Deary, Riccardo E Marioni, Sodbo Sharapov, Adam S. Butterworth, Anders Mälarstig, James WIlson, James Wilson, Pau Navarro, Linda Repetto, Fengyu Tu, Andreas Göteson
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Nature
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A single-cell pan-cancer analysis to show the variability of tumor-infiltrating myeloid cells in immune checkpoint blockade - Nature Communications
Abstract Myeloid cells are vital components of the immune system and have pivotal functions in orchestrating immune responses. Understanding their functions within the tumor microenvironment and their interactions with tumor-infiltrating lymphocytes presents formidable challenges across diverse cancer types, particularly with regards to cancer immunotherapies.
A general strategy for the synthesis of taxane diterpenes - Nature
Abstract The carbon skeleton of any organic molecule serves as the foundation for its three-dimensional structure, playing a pivotal role in determining its physical and biological properties.1As such, taxane diterpenes are one of the most well known natural product families, primarily owing to the success of their most prominent compound, paclitaxel, an effective anti-cancer therapeutic for more than 25 years.2-6 In contrast to classical taxanes, the bioactivity of cyclotaxanes (also...
Cerium‐doped Nickel Sulfide Nanospheres as Efficient Catalysts for Overall Water Splitting
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Cerium Doping‐Induced Enrichment of Ni3S4 Phase for Boosting Oxygen Evolution Reaction
Conflict of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset.
Optimal Non-Asymptotic Bounds for the Sparse β Model
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
The 70’s Biweekly: Social Activism and Alternative Cultural Production in 1970s Hong Kong
An examination of the 1970s art and culture scene in Hong Kong through the lens of an independent youth magazine. Taking The 70’s Biweekly–an independent youth publication in 1970s Hong Kong–as the main thread, this edited collection investigates an unexplored trajectory of Hong Kong’s cultural and artistic production in the 1970s.
How FoundationDB works and why it works
FoundationDB is a very impressive database. Its paper won the best industry paper award in SIGMOD'21. In this post, I will explain, in detail, how FDB works and discuss a few very interesting design choices they made. It's a dense paper packed with neat ideas. Many details (sometimes even proof of correctness) are not included in the paper. I added proof wherever necessary. What is FoundationDB?
Molecular Ferroelectric with Directional Polarization Field for Efficient Tin‐Based Perovskite Solar Cells
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202305852-sup-0001-SuppMat.pdf1.4 MB Supporting Information References 1, , , , , , , , , Adv. Energy Mater. 2021, 11, 2101085. 2, , , , , , Energy Environ. Sci. 2020, 13, 4017. 3 NREL, https://www.nrel.gov/pv/cell-efficiency.html, (accessed: May 2023). 4, , , , , , , , Nat. Commun. 2020, 11, 310. 5, , , , Nat. Mater. 2016, 15, 247. 6, , , , , , Nature 2020, 578, 555. 7, , , , , , , , , , Chem. Eng.
Earth’s evolving geodynamic regime recorded by titanium isotopes - Nature
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Abstract Earth’s mantle has a two-layered structure, with the upper and lower mantle domains separated by a seismic discontinuity at about 660 km (refs. 1,2). The extent of mass transfer between these mantle domains throughout Earth’s history is, however, poorly understood. Continental crust extraction results in Ti-stable isotopic fractionation, producing isotopically light melting residues3,4,5,6,7.
By Zhengbin Deng, Martin Schiller Verified, Matthew Jackson, Lu Pan, Dongyang Huang, Katrine Nikolajsen, Nikitha S. Saji
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Nature
Verified
Two-dimensional Janus pentagonal MSeTe (M = Ni, Pd, Pt): promising water-splitting photocatalysts and opto-electronic materials
Two-dimensional Janus pentagonal MSeTe (M = Ni, Pd, Pt): promising water-splitting photocatalysts and opto-electronic materials Inspired by the interesting and novel properties exhibited by Janus transition metal dichalcogenides (TMDs) and two-dimensional pentagonal structures, we here investigated the structural stability, mechanical, electronic photocatalytic, and optical properties for a class of two-dimensional (2D) pentagonal Janus TMDs, namely penta-MSeTe (M = Ni, Pd, Pt) monolayers, by...
Suppression of NLRP3/Caspase-1/GSDMD Mediated Corneal Epithelium Pyrop
Back to Journals » International Journal of Nanomedicine » Volume 18 Authors Lou Q, Pan L, Xiang S , Li Y, Jin J, Tan J, Huang B, Nan K, Lin S Received 4 January 2023 Accepted for publication 3 May 2023 Published 9 May 2023 Volume 2023:18 Pages 2447—2463 DOI https://doi.org/10.2147/IJN.S403337 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Prof.
Suppression of NLRP3/Caspase-1/GSDMD Mediated Corneal Epithelium Pyrop
Back to Journals » International Journal of Nanomedicine » Volume 18 Authors Lou Q, Pan L, Xiang S , Li Y, Jin J, Tan J, Huang B, Nan K, Lin S Received 4 January 2023 Accepted for publication 3 May 2023 Published 9 May 2023 Volume 2023:18 Pages 2447—2463 DOI https://doi.org/10.2147/IJN.S403337 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Prof.
Single‐Atom or Dual‐Atom in TiO2 Nanosheet: Which is the Better Choice for Electrocatalytic Urea Synthesis?
Graphical Abstract Dual-atom Pd1Cu1 active center in Pd1Cu1−TiO2 is more favourable for producing urea, which experiences a C−N coupling pathway with a lower energy barrier as compared with single-atom Pd1 in Pd1−TiO2. Abstract As rising star materials, single-atom and dual-atom catalysts have been widely reported in the electro-catalysis area. To answer the key question: single-atom and dual-atom catalysts, which is better for electrocatalytic urea synthesis?
Discover Paxos via 2pc
2pc and Paxos are solving the same problem Two Phase Commit, a.k.a 2pc, is a very well-known and intuitive algorithm, often used for coordinating transactions. Paxos is a well-known consensus algorithm, often used for replication on a stateful service. Paxos is less intuitive and harder to grasp. Atomic commit is a classic 2pc use case. E.g. you want to commit a transaction touching different MySQL shards.
T cell responses at diagnosis of amyotrophic lateral sclerosis predict disease progression - Nature Communications
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, involving neuroinflammation and T cell infiltration in the central nervous system. However, the contribution of T cell responses to the pathology of the disease is not fully understood.
Two-dimensional AlXY (X= S, Se and Y = Cl, Br, I) monolayers： promising photocatalysts for water splitting with high anisotropic carrier mobilities
Two-dimensional AlXY (X= S, Se and Y = Cl, Br, I) monolayers： promising photocatalysts for water splitting with high anisotropic carrier mobilities Lu Pan, Tian Zhang, Cui-E Hu, Xiang-Rong Chen and Huayun geng Abstract We here report a new group of two-dimensional (2D) AlXY (X= S, Se and Y = Cl, Br, I) monolayers by means of first-principles calculations. These AlXY monolayers are found to possess favorable dynamic, thermal and mechanical stabilities.
[PbX6]4− Modulation and Organic Spacer Construction for Stable Perovskite Solar Cells
[PbX6]4− Modulation and Organic Spacer Construction for Stable Perovskite Solar Cells Lian Wang, Bohong Chang, Hui Li, Lu Pan, yutong Wu, Zhen Liu and Long-Wei Yin Abstract The unique lattice structure and chemical bonding nature of perovskites endow them with illustrious photovoltaic properties, which have enabled perovskite solar cells (PSCs) to reach a power conversion efficiency (PCE) of 25.7%, approaching that of commercial silicon-based devices.
When and How to Invalidate Cache
In this post, I will talk about one way to figure out when to invalidate cache entries. I will use the following setup as an example, which should be general enough, and at the end of the post, I will briefly talk about how to generalize it even more.
Cache made consistent: Meta’s cache invalidation solution
Caches help reduce latency, scale read-heavy workloads, and save cost. They are literally everywhere. Caches run on your phone and in your browser. For example, CDNs and DNS are essentially geo-replicated caches. It’s thanks to many caches working behind the scenes that you can read this blog post right now.
Recognition of the inherently unstable H2A nucleosome by Swc2 is a major determinant for unidirectional H2A.Z exchange
Highlights • Swc2-Z is a specific Swc2 region interacting with the nucleosome acidic patch • Swc2-Z facilitates the disassembly of the inherently unstable H2A nucleosome • H2A and H2A.Z residues in M4 regions affect nucleosome stability • Loss of Swc2-Z decreases SWR1 activity in vitro and in vivo Summary The multisubunit chromatin remodeler SWR1/SRCAP/p400 replaces the nucleosomal H2A-H2B dimer with the free-form H2A.Z-H2B dimer, but the mechanism governing the unidirectional H2A-to-H2A.Z...
Publisher Correction: The Extended Polydimensional Immunome Characterization (EPIC) web-based reference and discovery tool for cytometry data
Correction to: Nature Biotechnology https://doi.org/10.1038/s41587-020-0532-1, published online 21 May 2020. In the version of this article initially published online, a portion of the image in Fig. 2c was shifted relative to the remainder. The error has been corrected in the print, PDF and HTML versions of the article. Author information Author notes These authors contributed equally: Joo Guan Yeo, Martin Wasser.
The Extended Polydimensional Immunome Characterization (EPIC) web-based reference and discovery tool for cytometry data
Fig. 1: EPIC bio-informatics toolkit. Fig. 2: Exploration of EPIC data and user-generated data. Fig. 3: EPIC data analytics using an elderly cohort and user uploaded data. Data availability The EPIC web portal and its associated database and analytic tools will be made available for investigation as described in the manuscript to researchers who do not belong to a for-profit entity.
Expulsion by pollution: the political economy of land grab for industrial parks in rural China
ABSTRACT This paper aims to broaden the analysis of the social-ecological impact of land grab. It does so by examining a hidden form of dispossession – expulsion by pollution within the context of industrial transfer inside China. Expulsion by pollution is different from the land dispossession described in most land grab studies as it involves expelling people from their land by reducing its use value through pollution, rather than taking the land away.
The impact origin and evolution of Chryse Planitia on Mars revealed by buried craters
Abstract Large impacts are one of the most important processes shaping a planet’s surface. On Mars, the early formation of the Martian crust and the lack of large impact basins (only four unambiguously identified: Hellas, Argyre, Utopia, and Isidis) indicates that a large part of early records of Mars’ impact history is missing.
Pathways toward high-performance inorganic perovskite solar cells: challenges and strategies
Pathways toward high-performance inorganic perovskite solar cells: challenges and strategies Bo Li,a Lin Fu,a Shuang Li,a Hui Li,a Lu Pan,a Lian Wang,a Bohong Changa and Longwei Yin*a Author affiliations * Corresponding authors a Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials, Ministry of Education, School of Materials Science and Engineering, Shandong University, Jinan 250061, P. R.
Multidimensional analyses reveal distinct immune microenvironment in hepatitis B virus-related hepatocellular carcinoma
Multidimensional analyses reveal distinct immune microenvironment in hepatitis B virus-related hepatocellular carcinoma Chun Jye Lim1, Yun Hua Lee1, Lu Pan1, Liyun Lai1, Camillus Chua1, Martin Wasser1, Tony Kiat Hon Lim2,3, Joe Yeong2,4, Han Chong Toh3,5, Ser Yee Lee3,5,6, Chung Yip Chan3,5,6, Brian KP Goh3,5,6, Alexander Chung3,5,6, Mathias Heikenwälder7, Irene OL Ng8, Pierce Chow3,5,6, Salvatore Albani1, Valerie Chew1 1 Translational Immunology Institute (TII), SingHealth-DukeNUS Academic...
Immune activation underlies a sustained clinical response to Yttrium-90 radioembolisation in hepatocellular carcinoma
Immune activation underlies a sustained clinical response to Yttrium-90 radioembolisation in hepatocellular carcinoma Valerie Chew1, Yun Hua Lee1, Lu Pan1, Nurul J M Nasir1, Chun Jye Lim1, Camillus Chua1, Liyun Lai1, Sharifah Nur Hazirah1, Tony Kiat Hon Lim2,3, Brian K P Goh3,4,5, Alexander Chung3,4,5, Richard H G Lo3,4,6, David Ng3,4,7, Rene L F Filarca3,4,5, Salvatore Albani1, Pierce K H Chow3,4,5 1 Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre,...
Multidimensional analyses reveal distinct immune microenvironment in hepatitis B virus-related hepatocellular carcinoma
Understanding the composition of the immune landscape within a cancer is also central to our understanding of responsiveness to immunotherapy. Recent breakthroughs in cancer immunotherapy, especially the development of immune checkpoint inhibitors, have yielded promising outcomes in clinical trials for multiple cancers, including HCC. 7 8 Despite these advances, fundamental differences in patient responsiveness to such therapies are unexplained.
Multidimensional analyses reveal distinct immune microenvironment in hepatitis B virus-related hepatocellular carcinoma
Understanding the composition of the immune landscape within a cancer is also central to our understanding of responsiveness to immunotherapy. Recent breakthroughs in cancer immunotherapy, especially the development of immune checkpoint inhibitors, have yielded promising outcomes in clinical trials for multiple cancers, including HCC. 7 8 Despite these advances, fundamental differences in patient responsiveness to such therapies are unexplained.
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