Luis B. Barreiro
Chicago, Montreal
Professor at the University of Chicago
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Written in our genes, epigenetically edited by infection - Nature Genetics
Understanding how infections reshape the human immune system requires integration of environmental, genetic and cellular sources of variability. Wang et al. leverage natural infection as a shared perturbation to reveal how genetic backgrounds modulate epigenetic responses.
Rewiring the bone marrow: Evolution and the transcriptional architecture of trained immunity
The TF groups described above are not activated in isolation but are selectively engaged depending on the stimulus and the cytokines it induces. Below, we summarize evidence from key models of hematopoietic reprogramming to illustrate how these transcriptional programs are deployed in vivo. The stimuli that lead to hematopoietic reprogramming engage various combinations of TFs from these classes.
Author Correction: β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus - Nature Immunology
Correction to: Nature Immunology https://doi.org/10.1038/s41590-024-02041-2, published online 8 January 2025. In the version of the article initially published, there were duplicate graphs in Fig. 5a, where the bottom-right Ifnar1–/– panel was a duplicate of the top-left control. The corrected Fig. 5 is now available in the HTML and PDF versions of the article.
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