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Articles by Manli Wang
Electron-Withdrawing Crystalline Pd/Amorphous PdS Drives Dynamic Electron Buffering and Sulfur Locking for Stable CO 2 -to-Formate Reduction
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description adfm78749-sup-0001-SuppMat.pdf14.5 MB Supporting File: adfm78749-sup-0001-SuppMat.pdf.
Dissociation and reassembly of the trimeric ectodomain of a baculoviral fusion protein during low-pH treatment
Keywords class I membrane fusion protein fusion intermediate cryo-electron microscopy baculovirus fusion peptide Get full text access Log in, subscribe or purchase for full access. References 1. White, J.M. ∙ Ward, A.E. ∙ Odongo, L. ... Viral Membrane Fusion: A Dance Between Proteins and Lipids Annu. Rev. Virol. 2023; 10:139-161 2. Colman, P.M. ∙ Lawrence, M.C. The structural biology of type I viral membrane fusion Nat. Rev. Mol. Cell Biol. 2003; 4:309-319 3. Kielian, M.
Structures and inhibition of the Crimean–Congo haemorrhagic fever virus polymerase
Abstract Crimean–Congo haemorrhagic fever virus (CCHFV) is a tick-borne virus and causes severe, often fatal, human infections. Lacking licensed vaccines or drugs, CCHFV is a World Health Organization priority pathogen requiring urgent development of medical countermeasures1,2. The CCHFV Large (L) protein functions as the viral RNA-dependent RNA polymerase CCHFV-L, representing a promising antiviral target, and is among the largest viral polymerases in the order Bunyavirales.
RNA synthesis and substrate analog inhibition in the CCHFV polymerase
Abstract The about 4000-residue L proteins from the Nairoviridae are the largest known viral polymerases, lacking global structural information and promising nucleotide analog (NA) inhibitors. Here we report structures of full-length Nairoviridae Crimean-Congo hemorrhagic fever virus (CCHFV) L including a 3.0-Å-resolution polymerase elongation complex that elucidates mechanisms of both early and late elongation stages.
Elevated serum plasminogen activator inhibitor-1 is associated with seizure burden, drug resistance, and neuroinflammatory markers in pediatric epilepsy
Abstract Background: Neuroinflammation and blood-brain barrier (BBB) disruption are increasingly recognized as key pathophysiological mechanisms in epilepsy. Plasminogen Activator Inhibitor-1 (PAI-1), a critical regulator of fibrinolysis and extracellular matrix remodeling, has been implicated in inflammatory processes, but its specific role in pediatric epilepsy remains largely unexplored.
Effect of organic material addition combined with tillage systems on organic carbon components and microbial communities in corn-fields of North East China
Abstract Organic material return (OMAR) and tillage systems are crucial agricultural management practices that govern soil microbial properties and organic carbon (OC) content, thereby fundamentally determining soil fertility. However, the precise mechanisms by which these practices mediate microbial activity to enhance distinct OC fractions remain poorly understood.
A blood-brain barrier-like vascular gate limits immunotherapy efficacy in neuroendocrine cancers
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Keywords blood-brain barrier-like vascular gate SCLC neuroendocrine cancers immunotherapy ASCL1-IGFBP5-IGF1R axis T cell infiltration OSI-906 Get full text access Log in, subscribe or purchase for full access. References 1. Sen, T. ∙ Dotsu, Y. ∙ Corbett, V. ... Pulmonary neuroendocrine neoplasms: the molecular landscape, therapeutic challenges, and diagnosis and management strategies Lancet Oncol. 2025; 26:e13-e33 2. Auernhammer, C.J. ∙ Spitzweg, C. ∙ Angele, M.K. ...
By Yiyun Wang, Ailing Zhong, Bo Wang, Xiaoqian Zhai, Chang Lei, Zuoyu Liang, Xintong Deng, Jian Zhong, Chaoxin Xiao, Jianan Zheng, Baohong Wu, Lanxin Zhang, Yuying Wang, Jian Wang, Hongyu Liu, Xudong Wan, Siqi Dai, Yucen Yang, Shiyu Zhang, Weiya Wang, Shengyong Yang, Jianxin Xue, Chengjian Zhao, Tuomas Tammela, Zhiming Li, Yan Zhang, Feifei Na, Manli Wang, Yu Liu, Chong Chen, Xiangmeng Luo, Mengsha Zhang
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Cell Press
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Iron overload reprogramming lipid metabolism through the IRP1–SCAP axis in fibroblast-like synoviocytes aggravates bone destruction in rheumatoid arthritis
Abstract Rheumatoid arthritis (RA) is a leading cause of disability globally. Although iron accumulation in arthritic lesions has been observed in patients with RA, its specific contribution to disability outcomes remains unclear. Here we demonstrate a comprehensive multiomics approach to elucidate the impact and underlying mechanisms of iron overload in RA.
Optimization of Liquid‐Based Cytology Block Preparation Using Modified Adhesive Centrifugal Sedimentation for Improved Diagnostic Accuracy in Cervical Lesions - Liu - 2026 - APMIS - Wiley Online Library
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
Time‐Domain Factorized Wave Model and Iterative Beamforming for Localizing Multiple Leaks in Water Pipes
1 Introduction Urban water distribution pipes are the lifelines of modern society, underpinning the public health of 4.5 billion people and the economic stability of 10,000 cities worldwide. Most of the water pipes have been buried underground over half a century and are approaching the end of their service lives (Che et al., 2021).
Bisphenol B Exposure Induces Miscarriage by Suppressing Migration/Invasion and Migrasome Formation
1 Introduction First-trimester miscarriage (or early pregnancy loss) is one of the most common complications in pregnancy.[1, 2] Approximately 15–25% pregnant women experience spontaneous miscarriage, and 1–5% suffer from recurrent miscarriage.[3] Many factors might induce miscarriage, including chromosomal abnormalities, uterine deformation, hormonal abnormalities, infections, psychological trauma and stressful life events, and immune disorders.[4] However, there are still 50% causes...
Two-Stage Transient-Based Leak Detection in Water Supply Pipe Networks
Data Availability Statement Some or all data, models, or code that support the findings of this study are available from the corresponding author upon reasonable request. Acknowledgments This research is supported by the Hong Kong Research Grants Council (RGC) under projects No. 15202122 and No. 15201523 and the National Natural Science Foundation of China (NSFC) under project No. 52209084.
Conserved Cysteines of a Putative Zinc Finger Motif in p48 Are Important for the Nuclear Egress of Nucleocapsids and the Envelopment of Occlusion-Derived Virions
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Ternary PdIrNi Telluride Amorphous Mesoporous Nanocatalyst for Efficient Electro-Oxidation of Ethylene Glycol
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Historical Pollution Exposure Impacts on PM2.5 Dry Deposition and Physiological Responses in Urban Trees
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
A robust Ni single-atom catalyst for industrial current and exceptional selectivity in electrochemical CO2 reduction to CO
A robust Ni single-atom catalyst for industrial current and exceptional selectivity in electrochemical CO2 reduction to CO While achieving a Faradaic efficiency (FE) over 90% in the electroreduction of CO2 to CO with single transition metal atom anchored on nitrogen-doped carbon (M-N-C) catalyst is indeed notable, the challenge remains in elevating the CO current density to a level suitable for industrial application.
Facile one-pot synthesis of mulberry-shape silver nanoparticlesdoped porphyrin nanoassembly with self-promoted electrochemiluminescence
Facile one-pot synthesis of mulberry-shape silver nanoparticlesdoped porphyrin nanoassembly with self-promoted electrochemiluminescence The electrochemiluminescence (ECL) efficiency of porphyrins is limited by the quenching of π-π stacking due to their poor water solubility and inherent instability. There is an urgent need to design and explore novel porphyrin luminophores with high ECL efficiency, which presents a significant challenge.
Interactome profiling of Crimean-Congo hemorrhagic fever virus glycoproteins - Nature Communications
Abstract Crimean-Congo hemorrhagic fever virus (CCHFV) is a biosafety level-4 pathogen requiring urgent research and development efforts. The glycoproteins of CCHFV, Gn and Gc, are considered to play multiple roles in the viral life cycle by interactions with host cells; however, these interactions remain largely unclear to date. Here, we analyzed the cellular interactomes of CCHFV glycoproteins and identified 45 host proteins as high-confidence Gn/Gc interactors.
N-(4-Aminobutyl)-N-ethylisopropanol and Co2+ Dual-Functionalized Core-Shell Fe3O4@Au/Ag Magnetic Nanomaterials with Strong and Stable Chemiluminescence for a Label-Free Exosome Immunosensor | Analytical Chemistry
Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2023, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Corrosion Mechanisms of a Biodegradable Zn-0.4Li Alloy in Simulated Gastrointestinal Environment
1. Introduction Gastrointestinal cancer has become one of the cancers with the highest morbidity and mortality. When removing a diseased intestinal tract, mechanical anastomosis is employed to reconstruct the continuity of the intestinal tract.
Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer
Banno T. Gazel A. Blumenberg M. Effects of tumor necrosis factor-alpha (TNF alpha) in epidermal keratinocytes revealed using global transcriptional profiling. J. Biol. Chem. 2004; 279: 32633-32642 Banno T. Gazel A. Blumenberg M. Pathway-specific profiling identifies the NF-kappa B-dependent tumor necrosis factor alpha-regulated genes in epidermal keratinocytes. J. Biol. Chem. 2005; 280: 18973-18980 Barrett A.J. Kembhavi A.A. Brown M.A. Kirschke H. Knight C.G. Tamai M. Hanada K.
The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro
Dear editor, Since December 2019, a novel disease COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread to over 200 countries and infected over 1.50 million people including 92,798 deaths (data as of April 10, 2020). On March 11, the World Health Organization (WHO) characterized COVID-19 as a pandemic, and called for accelerating diagnostics, vaccines, and drugs developments to combat this novel disease.
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