Mark Looney
San Francisco
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Articles by Mark Looney
Diet at disease onset determines tissue inflammatory memory
Abstract Obesity, which is often associated with prolonged exposure to an obesogenic diet, substantially alters immunity1,2,3,4,5,6,7, but whether brief dietary changes shape acute inflammatory responses and long-term tissue memory remains unclear. Here we show that transient high-fat diet (HFD) exposure at the onset of acute type 17 skin inflammation exacerbates disease in lean mice to levels comparable to those associated with chronic obesity.
GPCR-Gα13 signaling regulates survival of intestinal intraepithelial CD8 + lymphocytes through migration to cytokine-rich niches
Keywords intraepithelial lymphocyte CD8 T cells gamma delta T cells heterotrimeric Ga13 protein intestine cell migration GPR132 tissue resident memory Get full text access Log in, subscribe or purchase for full access. References 1. McDonald, B.D. ∙ Jabri, B. ∙ Bendelac, A. Diverse developmental pathways of intestinal intraepithelial lymphocytes Nat. Rev. Immunol. 2018; 18:514-525 2. Edelblum, K.L. ∙ Shen, L. ∙ Weber, C.R. ... Dynamic migration of γδ intraepithelial lymphocytes requires occludin Proc.
NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K + T cells
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Keywords inflammaging immune aging fibroblasts adventitia NF-κB TNFAIP3 GZMK+ T cells T cell exhaustion tertiary lymphoid structure ARDS lung Get full text access Log in, subscribe or purchase for full access. References 1. Liu, Z. ∙ Liang, Q. ∙ Ren, Y. ... Immunosenescence: molecular mechanisms and diseases Signal Transduct. Target. Ther. 2023; 8, 200 2. Franceschi, C. ∙ Bonafè, M. ∙ Valensin, S. ... Inflamm-aging. An evolutionary perspective on immunosenescence Ann. N. Y. Acad. Sci. 2000; 908:244-254 3.
By Nancy Allen, Christian Ringler, Jin Lee, Nabora S. Reyes, Ritusree Biswas, Lucile Neyton, Andrew Willmore, Sofia E. Caryotakis, Jessica Roginsky, Lu Guo, Mélia Magnen, Pedro Ruivo, Chaz Langelier, Mark Looney, Averil Ma, Vincent C Auyeung, Carolyn S Calfee, Ari B. Molofsky, Tien Peng, Sophie Phipps
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Cell Press
Verified
Megakaryocyte and platelet thrombospondin-1 regulates matrix remodeling by stabilizing basement membrane COL6A1 in lung injury
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Abstract An early event after lung injury is extracellular matrix (ECM) remodeling and the formation of a provisional matrix. While megakaryocytes and platelets (Mgk/plt) play important roles in hemostasis, their impact on the matrix in lung injury is not fully understood.
By Hernán F. Peñaloza, Atish Prabhakar Gheware, Ananya Gupta, Anupam Kumari, Xingan Wang, Gregory Gibson, Jae-Sung Kim, Bo-Ram Jin, Mélia Magnen, William Bain, Mohammadreza Tabary, Liwen Zhang, Tomasz W. Kaminski, Tomasz P. Kamiński, Prithu Sundd, Kyunghee Choi, Anuradha Ray, Prabir Ray, Rama K. Mallampalli, Sébastien Gingras, Matthew R. Rosengart, Mark Looney, Jonathan K Alder, Jaehyung Cho, Claudette St. Croix, Janet Lee, Donovan Watza, Shekina Gonzalez-Ferrer, Zeyu Xiong, Pooja Bhojraj, Rick van der Geest, Arpad Somogy
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Nature
Verified
Evolving TRALI risk across apheresis and whole blood platelet products in the United States: An 18‐year American Red Cross hemovigilance analysis
Optimizing MEMS IMU Data Coherence and Timing in Navigation Systems
Abstract For those seeking to assess inertial sensing solutions for the first time, existing computing and I/O resources may limit data rates and synchronization functions, which might impede progress toward proper in situ assessment of sensor capability. One of the most common challenges is establishing time-coherent data capture, at data rates that MEMS IMUs require, for the best available performance and digital post-processing capacity.
PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer - Nature
Abstract To grow at distant sites, metastatic cells must overcome major challenges posed by the unique cellular and metabolic composition of secondary organs1. Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease that metastasizes to the liver and lungs. Despite evidence of metabolic reprogramming away from the primary site, the key drivers that dictate the ability of PDAC cells to colonize the liver or lungs and survive there remain undefined.
Optimizing MEMS IMU data coherence and timing in navigation systems
Story Systems developers can use certain techniques to manage the gap between slow/asynchronous computing loops and high-performance data capture and processing in MEMS IMUs [micro-electromechanical system inertial measurement units] (MEMS IMUs >2000 Hz).
Understanding megakaryocyte phenotypes and the impact on platelet biogenesis
Corresponding Author Mark R. Looney Departments of Medicine and Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA Correspondence Mark R. Looney, Departments of Medicine and Laboratory Medicine, University of California, San Francisco, 513 Parnassus Avenue, HSE 1355A, San Francisco, CA 94143, USA. Email: mark.looney@ucsf.edu Search for more papers by this author
Reply: The importance of disrupting complement activation in acute lung injury
Letter to the EditorImmunologyPulmonology Open Access | 10.1172/JCI182451 Published in Volume 134, Issue 12 on June 17, 2024 J Clin Invest. 2024;134(12):e182451. https://doi.org/10.1172/JCI182451. © 2024 Cleary, et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Simon J. Cleary, … , James C. Zimring, Mark R.
Hexamerization: explaining the original sin of IgG-mediated complement activation in acute lung injury
Abstract Although antibody-mediated lung damage is a major factor in transfusion-related acute lung injury (ALI), autoimmune lung disease (for example, coatomer subunit α [COPA] syndrome), and primary graft dysfunction following lung transplantation, the mechanism by which antigen-antibody complexes activate complement to induce lung damage remains unclear.
Is neutrophilic inflammation treatable in COVID-19?
As the world is entering the third year of the COVID-19 pandemic, the discovery of effective treatments continues to be a global health priority. Despite vaccination success, promising antiviral drugs, and benefits of pharmacological immunomodulation for patients who are hospitalised with severe COVID-19, systemic hyperinflammation currently cannot be fully controlled and remains a major cause of morbidity and mortality.
Local Cyclist Completes Great Lakes Circle Tour
Split Rock Light house overlooking Lake Superior. A 4200-mile bicycle journey around each of the Great Lakes came to an end on May 31, 2019. I, Mark Looney, a resident of Lakewood, Ohio started my first exploratory trip around Lake Erie in 2015, then adding a new Lake in each of the four years that followed. For me, a childhood curiosity of living on the shores of Lake Ontario to “see what was on the other side,” grew into a series of authentic adventures into adulthood.
A consensus redefinition of transfusion‐related acute lung injury
Abstract BACKGROUND Transfusion‐related acute lung injury (TRALI) is a serious complication of blood transfusion and is among the leading causes of transfusion‐related morbidity and mortality in most developed countries. In the past decade, the pathophysiology of this potentially life‐threatening syndrome has been increasingly elucidated, large cohort studies have identified associated patient conditions and transfusion risk factors, and preventive strategies have been successfully implemented.
MEMS Vibration Monitoring: From Acceleration to Velocity
MEMS accelerometers have finally reached a point where they are able to measure vibration on a broad set of machine platforms. Recent advances in their capability, along with the many advantages that MEMS accelerometers already had over more traditional vibration sensors (size, weight, cost, shock immunity, ease of use), are motivating the use of MEMS accelerometers in an emerging class of condition-based monitoring (CBM) systems.
The Power of Low Noise in IoT Smart Sensors
Performance vs. power dissipation—it’s one of the most delicate tradeoffs for those who develop smart sensors for the emerging IoT-based application space. Within the broad spectrum of “performance,” noise is often an important attribute to evaluate, as it can constrain component selection for key functional blocks in a smart sensor, which in turn can increase the power burden.
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